硕士研究生课现代分子生物学专题细胞凋亡与肿瘤治疗刘小珊

1、ApoptosisNov, 2008Cell sociologyCell behavior Proliferation Differentiation Cell death Cell mobilityCell deathZakeri Z, Lockshin RA. Cell death: history and future. Adv Exp Med Biol. 2008;615:1-11.Zakeri Z, Lockshin RA. Cell death in health and disease. Journal of cellular and molecular medicine, 20

2、07;11: 1214-1224.Richard A. LockshinFrom Wikipedia, the free encyclopedia In 1964, Lockshin and Williams published their landmark contribution on Endocrine potentiation of the breakdown of the intersegmental muscles of silkmoths, in which they coined the term, programmed cell death“Richard Lockshin

3、has made significant contributions to the cell death community. He was one of the founders of the International Cell Death Society and acted as the societys President from 1998 to 2002.Richard Lockshin is currently a professor at St. Johns University (Jamaica, NY). Programmed cell

4、 deathDefinition of cell deathCell death Dying cell (in the process of cell death) Dead cellCell death typesCell death typesCell death typesEnzymological Classification of Cell DeathCell Death Differ. 2007;14(7):1237-43. Programmed cell deathProgrammed cell death=apoptosis=caspase activation= non-im

5、munogenic cell deathThe above is not correctPubMed1972年Br J Cancer. Kerr JF, Wyllie AH, Currie AR.Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.1965年 autophagy Pub numberWhy the research of cell death become popular Techniques Genetics Ubiquity DiseaseCan

6、cer and cell death Cancer-cell behavior Unlimited proliferation Blocked differentiation Escaping cell death High mobilityProgrammed cell deathApplication of Cell death in cancer1. Preventive medicine Carcinogenesis, Prevention of cancer2. Clinical medicineDiagnosisTherapyPrognosisChemotherapy, radio

7、therapy, surgery, biological therapyThe goal of cancer treatment :selectively kill cancer cellsCell death types in cancer cellNecrosis-not selectiveApoptosis-deficiency in apoptosis pathway Autophagy- survival pathway ?Mitotic catastrophe- apoptosisCell death in cancer therapyCancer cell: Deficiency in apoptosis pathway Taylor R et al. Nature reviews MCB,2008:231-Le