生物化学5-10章练习题英文版

1、【精品文档】如有侵权，请联系网站删除，仅供学习与交流生物化学5-10章练习题英文版.精品文档. Exercises of Chapter 5-10 A1.Which can transport acyl-CoA into the Mitochondria? ( )A .apolipoprotein B. lipoprotein C. albumin D. citrate E. carnitine 2. In which following conditions are ketone bodies synthesis greatly accelerated? ( )A .glycolysis i

2、s enhanced B. fat mobilization is enhanced C. fatty acid synthesis is enhanced D. malonyl CoA is reduced E. aerobic oxidation of glucose is enhanced3. How many moles of ATP are yielded when 1 mol glycerol is oxidized to CO2 and H2O ? ( )A .19 B. 16.5/18.5 C. 20/22 D.23 E. 174. which is the key enzym

3、e in the regulation of FA synthesis? ( )A .fatty acid synthase B. acetyl-CoA carboxylase C. keto-acyl-ACP synthase D.enoyl-ACP reductase E. thioesterase5. NADPH in FA synthesis comes from ( ): A .aerobic oxidation of glucose B. glycolytic pathway C. gluconeogenesis D.pentose phosphate pathway E. glu

4、curonate pathway6. which is not concerned with the cholesterol biosynthesis?A .acetyl-CoA B. HMGCoA C. NADPH +H+ D.seualene E. glycerol7. the active form of choline in phospholipid biosynthesis is:A .ADP-choline B. UDP-choline C. CDP-choline D. GDP-choline E. CMP-choline8. which is not concerned wit

5、h the glycerophospholipid biosynthesis? A .serine B. GTP C. ATP D. CTP E. choline9.which is specific function of apoA?A .activates LPL B. inhibits HL C. activates LCAT D. inhibits LCAT E. activates ACAT 10.which is not required in -Oxidation of Fatty AcidsA .CoASH B. NADP+ C. carnitine D. FAD E. NAD

6、+ 11. which is the primary carrier of cholesterol in the blood of humans?A .CM B. HDL C.VLDL D. LDL E. IDL12. How many moles of ATP are yielded when 1 mol stearic acid (18 C) is oxidized to CO2 and H2O ? ( ) A .146 B. 120 C. 165 D.182 E. 19913. which is an intermediate on the pathway for synthesis o

7、f ketone bodies and cholesterol?A .malonyl CoA B. acetoacetyl-CoA C. HMGCoA D. acetyl-CoA E. acetoacetate14. which is prosthetic group of acetyl-CoA carboxylase?A . NAD+ B. biotin C. NADP+ D. FAD E. FMN15. which is the key enzyme in the regulation of cholesterol synthesis? ( )A . HMGCoA synthase B.

8、squalene monooxygenase C. HMGCoA reductase D. squalene synthase E. HMGCoA thiolase16.which is the correct sequence of 4 reactions in fatty acids oxidation?A . dehydrogenation, redegydrogenation, hydration, thiolysis B. thiolysis, dehydrogenation, redegydrogenation, hydrationC. dehydrogenation, hydra

9、tion, redegydrogenation, thiolysis D. hydration, dehydrogenation, thiolysis, redegydrogenationE. dehydrogenation, thiolysis, redegydrogenation, hydration17. which is the major form that transports endogenous TAGs from the liver to the tissues?A .HDL B. LDL C.VLDL D.CM E. IDL18. which lipoprotein con

10、tains apoB100 mostly?A .HDL B. LDL C.VLDL D.CM E. CM remnants19. which lipoprotein contains apoB48 mostly?A .HDL B. LDL C.VLDL D.CM E. IDL 20. which enzyme s activator is apo C?A .LPL B. LCAT C.ACAT D.HL E. CETP 21. the net result of the oxidation of 1 mol palmitic acid (16C) will be ( ) mol ATP?A .

11、129 B. 96 C. 165 D.182 E. 106 22.which is the major form that participates in the reverse cholesterol transport?A . IDL B. HDL C. LDL D. VLDL E. CM 23.which is the rate limiting enzyme in the TAG degradation?A .HSL B. LPL C.DAG lipase D.HL E. MAG lipase 24.which hormone can accelerate fat mobilizati

12、on?A .epinephrine B.glucagons C.TSH D.ACTH E. all above25.which is anti-lipolytic hormone ?A .epinephrine B.glucagons C.TSH D.ACTH E. prostaglandin E226.which is essential fatty acid?A . stearic acid B. oleic acid C.linoleic acid D. palmitic acid E. oxaloacetic acid27.which is the pathway that acety

13、l-CoA is transported from the mitochondria into the cytosol to allow FA synthesis to occur?A . TAC cycle B. malate-asparate shuttle C.glucose pyruvate cycle D. citrate pyruvate cycle E. -glycerophosphate shuttle28. which is the key enzyme in -Oxidation of Fatty Acids? ( )A . carnitine acyl transfera

14、se B. carnitine acyl transferase C. acyl-CoA synthetase D. carnitine-acylcaritine translocase E. acetyl-CoA carboxylase29. the lack of ( ) means that ketone bodies are synthesized exckusively in the liver and must be used elsewhere.A . HMGCoA synthase B. succinyl CoA transsulfurase C. HMGCoA reducta

15、se D. acetoacetyl-CoA thiolase E. HMGCoA thiolase30. which agent is an inhibitor of electron transport at Complex ?A .rotenone B. antimycin A C. piericidin A D. amobarbital E. DNP31. which agent is not an inhibitor of electron transport at Complex ?A .carbon monoxide B. azide C. sulfureted hydrogen

16、D. amobarbital E. cyanide32. which is not the energy-rich compound?A .CP B. ATP C. PEP D. 1,3-bisphoglycerate E. 2,3-bisphoglycerate 33.the sequence of cytochrome in respiratory chain is :A. c-c1-b-aa3-O2 B. c1- c -b-aa3-O2 C. b -c1- c -aa3-O2 D. b - c - c1 -aa3-O2 E. c- b - c1 -aa3-O2 34. Which of

17、the following state is nitrogen equilibrium?A. advanced cancer patient B. pregnant women C. patient recovering from illness D. people suffer form long-time hunger E. normal adult35. Which of the following state that nutrition sufficicent infant in?A.nitrogen balance B.positive nitrogen balance C.net

18、ative nitrotgen balance D. nitrogen equilibrium E.none of the above36. Which of the following state is positive nitrogen balance?A.advanced cancer B. pregnant women C.people suffer from fever D. people suffer form long-time hunger E.normal adult37. Which of the following is not one carbon unit?CH3;

19、CH2; CO2; CH; CHO38. Which of the following is not produced by Tyr?norepinephrine;epinephrine;dopamine; Phe;melanin39. Which of the following is the main deamination style in muscle?Transamination;ornithine cycle;L-glutamate oxidation deamination;purine nucleotide cycle;-glutamyl cycle40. Which of t

20、he following is the storage and transportation style of ammonia?Glu; Tyr;GSH; Asn; Gln41. Which of the following is the main outlet of ammonia in mammalian? infiltrate to intestinaltract;synthesis of Gln;synthesis of urea in liver;synthesis of amino acid again; excrete out of the body in kidney42. W

21、hich of the following amino acid can not produce one carbon unit?Serine;Valine ;Tryptophan;Histidine ;Glycine 43.Which of the following ammino acids take part in the synthesis of creatine?Glycine,mehionine,arginine; Methionine,ornithine,citrulline; Glycine,methionine,citrulline; Glycine,arginine,orn

22、ithine;Ornithine,citrulline, arginine 44. Which of the following is the carrier of one carbon unit ? biotin; SAM; FH4; FH2; folic acid45. Which of the following is ketogenic amino acid only?Glycine; Leucine; Threonine; Isoleucine; Tyrosine46. Which of the following are the nitrogen source of urea ?c

23、arbomoyl phosphate and aspartate ;carbomoyl phosphate and ornithine; -amino group and-amino group of ornithine;-amino group of citrulline and-amino group of arginine;-amino group of ornithine and glycine47. Which of the following amino acid can produce PAPS? taurine; methionine; cysteine; homocystei

24、ne; glutamate48. Which of the following is the main deamination style in the body?oxidation deamination; reduction deamination;direct deamination; transamination; union deamination49. Which of the following is the process that transport ammonia from muscle to liver? TAC cycle;ornithine cycle;alanine

25、-glucose cycle;methionine cycle ; -glutamyl cycle50. Which of the following vitamin that the coenzyme of amino acid decarboxylase contain? C; B2; B12;B6;B151. Which of the following is the direct donor of CH3? N5-CH3-FH4; SAM; N5,N10- CH2-FH4; N5,N10=CH-FH4; FAD52. Which of the following is ketogeni

26、c and glucogenic amino acid ?Ala; Phe; His; Pro; Leu53. Which of the following is the main source of ammonia in kidney?union deamination of amino acid; hydrolysis of Gln;hydrolysis of urea ; nonoxidative deamination of amino aicd;oxidation of amine54. In the synthesis of urea, one N come from NH3, w

27、hich of the following amino acid provide another N for urea? Pro; Asp; Glu; Phe; Lys55. Which of the following is first synthesized in the process of de novo synthesis of purine nucleotide?GMP; AMP; IMP; ATP; GTP56. Which of the following is the end product of purine nucleotide catabolic metabolism?

28、 urea; creatine; creatinine; uric acid; -alanine57. Which of the following substance directly link nucleotide synthesis and glucose metabolism?glucose; glucose-6-phosphate ; glucose-1-phosphate ; glucose-1,6-diphosphate; ribose-5-phosphate58. Which of the following is not the direct material of de n

29、ove synthesis of purine nucleotide ? glycine; aspartate ; glutamate ; CO2 ; one carbon unit59. Which of the following material could provide C4 and C5 for purine ring?alanine; glycine; glutamate ; aspartate ; glutamine60. Which of the following provide only one C atom for purine synthesis?CO2; gluta

30、mine; glycine; aspartate; formic acid61. Which of the following provide two N atoms for pyrimidine ring? glutamine and ammonia ; glutamine and glutamate glutamine and carbomoyl phosphate; aspartate and carbomoyl phosphate; aspartate and glutamate 62.Which of the following is the common material for

31、the synthesis of pyrimidine and purine nucleotide?fumarate; glutamine ; formic acid ; asparagine; glycine63. Which of the following amino acid totally participate in the synthesis of purine nucleotide?glycine ; aspartate; glutamate ; glutamine ; asparagines64.Which of the following provide C2 for pu

32、rine ring? N5-CH3FH4; N10-CHO-FH4;N5，N10=CH-FH4; N5，N10-CH2-FH4; CO265. Which of the following is the energy source of brain for long-term starvation patient ? glucose; amino acid; glycerol; acetone body; glucogen66. Which of the following is not correct about chemical modification of key enzyme?the

33、 enzyme have two style: active and inactive ; the active style and inactive style can be interconverted by the other enzyme ; the enzyme that catalyze the interconversion can be controlled by the hormon; do not need energy; phosphorylation and dephosphorylation is the main style67. Which of the foll

34、owing is the main style of chemical modification?methylation and demethylation ; acetylation and deacetylation ; phosphorylation and dephosphorylation; polymerization and depolymerization ; synthesis and decomposition of enzyme68. Which of the following reaction take place in plasma?TAC ; oxidative

35、phosphorylation ; pyruvate carboxylation ; -oxidation of fatty acid ; synthesis of fatty acid69. In the condition of starvation, which of the following is not correct? insulin secretion is enhanced ; glucagon secretion is enhanced ;fat mobilization is enhanced ; synthesis of acetone body is enhanced

36、 ; glyconeogenesis is enhanced70. Which of the following is not correct about the substance metabolism in different tissues and organs ? liver is the hinge of the substance metabolism; glucose decomposition in heart is mainly aerobic oxidation ;the energy of brain usually come from glucose ;the ener

37、gy of red cell usually come from glycolytic pathway;liver is the only organ that have the reaction of glyconeogenesis71. Which of the following is not correct about the allosteric regulation ? the allosteric enzyme usually has two subunits ; the allosteric effectors usually are small materials ;the

38、allosteric effectors usually bind to the site out of the active center of the enzyme ; the end production of the pathway usually is the allosteric inhibitors of the enzyme that catalyze the initiation reaction of the pathway ; can be amplified72. Which of the following is not correct about the key e

39、nzyme? the key enzyme usually catalyze the first reaciton of the metabolic pathway ; the key enzyme has the highest activity; the key enzyme usually is the allosteric enzyme ; the key enzyme usually is regulated by hormone; the reaction that catalyzed by the key enzyme usually is the one-way reactio

40、n or equilibrium reaction73. Which of the following enzyme do not belong to chemical modification enzyme ? phosphorylase; glycogen synthetase; pyruvate kinase; malate dehydrogenase ; phosphorylase b kinase74. Which of the following metabolic pathway take place in the mitochondira?glycolytic pathway;

41、 the synthesis of acetone body; pentose phosphate pathway ; the synthesis of the fatty acid ; the synthesis of the glycogen75. Which of the following is the material of glyconeogenesis for short time starvation?glycerol ; glycerol-3-phosphate; alanine; pyruvate; lactate76. In the oxidation decomposi

42、tion of glucose ，fat and amino acid , which is the main compound that go into the TAC cycle?isocitrate ; pyruvate ; -ketoglutarate ; -keto acid ; acetyl CoA77. Which of the following is not the outlet of Acetyl CoA?go into the TAC cycle ; use to synthesize fat ; transition ot ketogenic amino acid ;

43、transition ot acetone body; transition to cholesterol78. Which of the following is the rate-limiting enzyme of glyconeogenesis ?Acetyl CoA carboxylase ; 7-hydroxylase; HMGCoA reductase; pyruvate carboxylase; 6-phosphofructokinase-179. Which of the following does not participate in DNA replication?he

44、licase; single strand binding protein; transciption factor; ligase ; primase80. DNA replication is a ( ) process.conservative; destructive; non-conservative; semi- conservative, random dipersive81. he primary structure of DNA is the squence of its nucletide residues connected by ( )?3,5-phosphodiest

45、er bonds; hydrogen bonds; peptide bonds; salt bonds; disulfide bonds82. When the two daughter strands of DNA replicated , ( )one strand in the 5 to 3 and the other in the 3 to 5direction; the both strands are all in the 3 to 5 direction; the both strands are all in the 5 to 3 direction; the both str

46、ands are all conservative replicated; the DNAsynthesis of leading strand is continuous 83Which one can separate the parental DNA strands? DnaC; DNA-pol; topoisomerase; primase ; helicase84Human telomerase RNA is one of the ( ).reverse transcriptase ; DNA-pol; RNA-pol; DNA ligase; DNA topoisomerase85

47、Which of these enzyme is not concerned with DNA replication？DNA dependent DNA polymerase; DNA dependent RNA polymerase; RNA dependent DNA polymerase; topoisomerase; DNA ligase86In the initiation of DNA replication, the proper order that following enzyme and protein acting is? 1, DNA-pol 2，SSB 3，prim

48、ase 4, helicase1,2,3,4; 4,2,3,1; 3,1,2,4; 1,4,2,3; 2,3,4,187Which of the following could proofreading, DNA repairing, filling of gaps?DNA pol; DNA pol ; DNA pol ; DNA pol; DNA pol88Which of the following have primase activity?DNA pol ; DNA pol; DNA pol ; DNA pol; DNA pol89Which of the following serv

49、e as DNA replication in mitochondria ?DNA pol; DNA pol; DNA pol ; DNA pol ; DNA pol90In DNA replication, what is the reason of Okazaki fragment generated? the speed of DNA replication is too fast ; bidirectional replication; come from primer; the direction of replication is different with that of un

50、winding; DNA be coiled and tied knots in replication91Which of the following is the product of the replication discontinuously?Klenow fragment; primer; leading strand ; lagging strand, Okazaki fragment92Which of the following is a short RNA?Klenow fragment; primer ;leading strand; lagging strand; Ok

51、azaki fragment.93Which of the following could contain the length of eukaryotic chromosome?telomerase；primase；SSB；DNA ligase；topoiserase94The template DNA is 5-ATAGC-3,and the daughter DNA is：5-GCTAG-3；5-GCTAT-3；5-GCATA-3；5-GATAT-3；5-TATCG-3.95Which of the following is the function of SSB ?unwingding

52、；to identify the ori of replication；synthetic primer；to stabilize the single strand；filling the gapX:which are correlated with FA synthesis?A . acetyl-CoA carboxylase B.ACP C.biotin D. NADPH +H+ E. acyl-CoA synthetase 2. which is essential fatty acid?A . oleic acid B. linolenic acid C.linoleic acid

53、D. arachidonate E. palmitic acid 3. which materials can not be transported from the mitochondria into the cytosol?A . acetyl-CoA B.pyruvate C. acyl-CoA D. oxaloacetic acid E. malate 4. the function of cholesterol is:A . conversion into vitamin D B. conversion into bile acid C. as a biological membra

54、ne D. providing energy E. conversion into cholesterol hormones 5. which material synthesis requires acetyl-CoA?A . fatty acid B.ketone bodies C. cholesterol D. lipoprotein E. sugar 6. which does not exist in hepatic cells?A . succinyl CoA transsulfurase B. acetyl-CoA carboxylase C. HMGCoA reductase

55、D. acetoacetyl-CoA thiolase E. acetoacetyl-CoA thiokinase7. utilization of ketone bodies in ( )A . heart B. brain C. kidney D. liver E. skeletal 8.proton pumps are ( ) where protons flow from the matrix to the intermembrane space and a membrane potential is formed.A . Complex B. Complex C. Complex D. Complex E. ATP Synthase9. which agents are inhibitors of electron transport at Complex?A .rotenone B. antimycin A C. piericidin A D. amobarbital E. BAL10. Which of the following are essential amino acids? phenylalanine； tyrosine； serine；threonine；leucine11. Which of the following substance need