MEMBRANA透析器

1、Underlining PerformanceOrt, Datum 2001Vorname NameMEMBRANA GmbHWuppertal G 0871DialysisTechnical microfiltrationOxygenationKey Branches0800Charlotte, USAWuppertal, GermanyOwensboro, USAOxygenationGas separationIndustrial & auto-motive SeparatorsLithium contactorsDialysisOxygenationIndustrial applica

2、tionsDialysisOxygenationTechnical applicationsGas separationIndustrial & auto-motive SeparatorsLithium contactorsCharlotte, USAWuppertal, CharlotteOwensboro (HQ), USA0885Private US company (owned by the InterTech group)HQ Charlotte, North CarolinaGlobal manufacturer and marketer of microporous membr

3、anes for use in- Energy storage industrial/automotive- Lithium contactors- Medical/industrial separation marketsApproximately US$ 400 million turnover10 plants in the USA/Europe/AsiaPolypore Inc. 5052Market Major trademarks Products Industrial and Automotive Daramic Armorib Darak Flatsheet Electroly

4、tic Membranes Lithium CELGARD Flatsheet Electrolytic Membranes Medical CUPROPHAN HEMOPHAN SMC Bioflux DIAPES OXYPHAN OXYPLUS Celgard X30-240 PLASMAPHAN MicroPES Hemodialysis(H) Blood Oxygenation Membranes (Oxy) Plasmapheresis (P) Industrial Liqui-Cel Aeroshoes Artisyn MicroPES UltraPES ACCUREL Indus

5、trial Applications and Filtration Products Energy StorageSeparations Media & OtherPolypore - Product Mix5053Manufacturing Facility Sales Office Headquarters* * Indicates facility under constructionBurlington, MABurlington, MACorydon, INCorydon, INOwensboro, KYOwensboro, KYCharlotte, NCCharlotte, NCS

6、ao Paulo, BrazilSao Paulo, BrazilHamburg, GermanyHamburg, GermanyPotenzaPotenza, Italy, ItalyS S lestatlestat, France, FranceTokyo, JapanTokyo, JapanBeijing OfficeBeijing OfficeBangkok, ThailandBangkok, ThailandVictoria, AustraliaVictoria, AustraliaPrachinburiPrachinburi, Thailand, ThailandPolypores

7、 Global Presence5054WuppertalWuppertal, , ObernburgObernburg, Germany, GermanyPolypore Specialty Products Aeroshoe moisture absorbent insoles Artisyn durable waterproof and moldable synthetic papers DAGA Equipment 0874 Polypore employs approx. 1,900 people worldwideEnergy Storage (65% of sales) Indu

8、strial and Automotive Separators Li-1(disposable) / Li-2 (Rechargeable) SeparatorsSeparations Media & Other (35% of sales) Medical (Hemodialysis, Blood Oxygenation, Apheresis) Industrial (e.g., water purification, semiconductor and microelectronics, food and beverage and pharmaceutical)Business Over

9、view5056Membrana GmbH Wuppertal - Plant0609Membrana GmbH Charlotte - Plant0887The Oehde when everything began0720/o695The main building is still existingDyeing company, 1865 built in the “Oehde”0690Dessous 1930Spinning machine model 1908Historical InsightsMembrana - Wuppertal Plant0704/07061951, rec

10、onstruction after World War 21956, Werkstrae 4”turkish red” dyeing companyfamous artificial “Bemberg silk”19201945196519741999/200019801920-40 major manufacturer of “artificial silk”, worldwidestart of CUPROPHAN productionstart of dialysis membrane productionstart of CUPROPHAN capillary membrane wor

11、ldwide leader in dialysisstart of technical membrane production (ACCUREL)1917J. P. Bemberg (major shareholder Vereinigte Glanzstoff Fabriken) 1925Glanzstoff AG merged withVereinigten Glanzstoff Fabriken 1971introduction of HEMOPHAN and OXYPHANMembrana s History198846091792start of SMC-membrane produ

12、ction1995introduction of DIAPES and OXYPLUSJ.P. Bemberg 1792, ab 1900 J. P. Bemberg AG Enka Glanzstoff AG 1972Enka AG 1977Akzo Faser AG 1991Enka AG / Akzo 1988Akzo Nobel Faser AG 1994Acordis 1999Membrana GmbH, Polypore 20022863Membrana - Key Facts 2002 A member of Polypore since 03/01/02 A leader in

13、 membranes for medical / industrial applications 950 employees Located in Wuppertal and Obernburg (Germany) and Charlotte, North Carolina (USA) Annual turnover of about 150 million Membrana headquartersStefan GeylerGeneral ManagerChristianVogelsangDirector Human ResourcesMartina Minten-SchalleyDirec

14、tor Control& Admin.Oliver SchusterVP R & DAllen PittmanVP Sales & MarketingInd. SeparationsUlf SeidelVP Sales & MarketingMed. SeparationsUwe SteinVP OperationsHartmut StenzelAccurel SystemsKlaus DombrowskiQA/LaboratoriesMembrana - Separations Media Group5034Business Volume Shares82%13%5%MSM/MMSM/IMA

15、S3372Medical SeparationsIndustrial SeparationsACCUREL SystemsStatus: 01/01/03 * Double functionSales & Marketing Medical Separations5081Business AnaylstMichael Pelger *MSM/M-SCCommunication/Market ResearchKadija RaoudiMSM/M-SCProduct Manager DialysisJens OsterlohProduct Manager OxygenationStefan Bre

16、iter *Marketing Projects /Online ServicesChristian GntherMarketing AssistantI. RosenthalMarketing ManagerStefan Breiter *MSM/M-MInternal SalesConcetta EspostoOrder Entry Charl.Area Sales ManagerAndreas Wodetzki *MSM/M-SCTech. Sales ManagerOxygenationAndreas Wodetzki *Technical Service OxygenationR &

17、 D CharlotteJ. J. LoweryOrder Entry Charlot.Area Sales ManagerAmericasTony MancusiTech. Sales ManagerDialysisBodo v. HartenInternal SalesS. SchulzInternal SalesKerstin EimbeckOrder Entry Charlot.Area Sales ManagerEuropeJrgen ScheurenMSM/M-SCTech. Sales ManagerDialysisMichael Pelger *Internal SalesDa

18、gmar PetigInternal SalesChrista KiepertJapan OfficeMika Kaifu / Maki NumataChina OfficeChi EngangOrder Entry Charlot.Area Sales ManagerAsia & AfricaThorsten BrandtMSM/M-SCSales ManagerApheresis & HemoconcentrationHorst MeierlingMSM/M-SCVP Sales & MarketingMedical SeparationsUlf SeidelMSM/M2864Membra

19、nas Product Range (1)Membranes for medical applications capillary membranes for renal replacement therapycellulosic low-flux membranes CUPROPHANsemisynthetic low-flux membranesHEMOPHAN, SMCsynthetic, membranes for all fluxesDIAPES, SYNPHAN capillary membranes for plasmaseparation(PLASMAPHAN, MicroPE

20、S) capillary membranes for cardiac therapy(OXYPHAN , OXYPLUS, CELGARD)Membranas Product Range (2)Membranes for technical applications flat and capillary membranes for microfiltration processes(PA6, ACCUREL PP, MicroPES and UltraPES) capillary membranes for technical dialysis (CUPROPHAN)Membrane Cont

21、actors for Degasification Liqui-CelPorous materials for controlled release or containment of various chemicals ACCUREL Systems2865Development of Dialyzers by Regions0,020,040,060,080,0100,0120,0140,0160,0180,0Mio PcsNAJapanW-EuropeROWgrowth p.a.growth p.a.7,1%7,0%7,1%7,2%7,1%7,1%7,2%7,3%7,4%ROW23,42

22、5,728,331,134,337,741,545,650,2W-Europe24,425,526,627,829,130,431,833,234,7Japan30,031,533,134,736,538,340,242,244,3NA13,014,416,117,919,721,623,826,329,020002001200220032004200520062007200890,897,8104,1111,6119,5128,0137,3147,3158,23370Cellulosics & Synthetics Worldwide0204060801001202000 2001 2002

23、 2003 2004 2005 2006 2007 2008Dialyzer Consumption Mio Pcs.0%10%20%30%40%50%60%70%pcs cellulosicsPcs Synthetics% Cellulosics% Synthetics33712868BloodDialyzerDialysate500ml/minDialysate + ultrafiltrate500ml/min200ml/minto wasteCapillary membranesDialysateBloodExtracorporeal Membrane Therapy - Hemodia

24、lysis -1246PolymerScienceMembraneTechnologyApplicationKnow-howClinicalExperiencePolymerMembraneDialyzerTreatmentPatientAreas of CompetenceFocusing on MembranesHemodialysis Membranes - Family Tree -RegeneratedCelluloseSyntheticallyModifiedCelluloseModifiedCelluloseCUPROPHAN (Membrana)Bioflux(Membrana

25、)EVAL C(Kuraray)EVAL D(Kuraray)PC(Gambro)PMMA(Toray)PAN-DX(Asahi)PAN(AN69/Hospal)PSu(F60/F6 Fresenius)PA(Gambro)PEPA(Nikkiso)Arylane(Gambro)HEMOPHAN(Membrana)PEG(Asahi)SMC(Membrana)Vit.E-RC(Terumo)CTA(Toyobo, Althin)CA(Toyobo, Althin)SCE(Teijin)RC(Teijin)RC(Terumo)RC(Asahi)SyntheticMembranesSYNPHAN(

26、Membrana)RegeneratedCellulose5005DIAPES(Membrana)HFHPLFDIAPESHF800FluxDIAPESHP200DIAPESLF100SMCHEMO-PHANSyntheticSemi SyntheticCellulosicLF+Blood UFR ml/hmmmHg3 - 710 - 1215 - 20 304927Performance SegmentationCUPRO-PHANDIAPESHF800XPHollow Fiber Spinning - Cuoxam Process3055SpinneretCross-section vie

27、wPolymer spinningsolutionCore liquidprecipitationextractionReservoirReservoirNaOHH2SO4H2OwashingGlycerolsoftener bathH2OIPAdryerwindingNH3, Cellulose, NaOH, CuSO4, H2OIsopropyl-myristateBore liquidSpinning solutionpumpfilterHEMOPHAN Excellent Phosphate Clearance by Hydrogel-Effect4328blood flowMecha

28、nism: reduction of the surface tension between the hydrogel and the phosphate-water-complex enables easy penetration of P- through the membraneblood flowdialysate flowDEAE+DEAE+DEAE+Concept of high performance andexcellent hemocompatibilitySMC - Synthetically Modified CelluloseOptimized by P.E.T. (P

29、erformance Enhancing Technology)4944SMC - The Optimized Membrane0490Principle of P.E.T. Membrane capillaries, specially combined with multifilament yarn4695SpinneretCross-section viewPolymer spinningsolutionBore liquidcoagulationpre-extractionBoreliquidPolymersolutionwrappingModular conceptairdrying

30、windingcuttingwatermake-uppipelineDIAPES Spinning Processextraction &dryingProduction DIAPES08050375DIAPES - Basic Molecule Structure= 10 nm= 100 nm= 5 nm30 mDIAPES Membrane Structure scanning electron microscopy 04340383Membrana - Partners in DialysisExtracorporeal Membrane Therapy - Plasmaseparati

31、on -ca. 40ml/minremovedplasma replacement by plasmaof healthy donors(therapeutic plasmapheresis)bloodplasmafilter200ml/mincapillarymembranes filteredplasmablood2867Membrane Separation Process3044DiffusionConcen-trationBloodFiltratePlasma6-30 mMembraneConvectionPressureApheresis: Therapeutic Plasmaex

32、change (TPE)3369General principle separation of plasma from the blood removal of pathological parts in the plasma Immunological Antibodies (IgM, IgG, IgA) Complement activation (C3, C3b, C5a, C9, .) Non-immunological Toxines Products of metabolic disorder Rheological improvementOxygenation CasesOpen

33、 Heart Operations excl. PTCA Worldwide 02004006008001.0001.2001.4001.6001.8002.0001996199820002002200420062008- 1,000 -Bypassoff pumpOther OH-OpsH.ValvesBypasson pump3373Oxygenations Procedures: PotentialHeart Operations excl. Off-Pump Bypass and PTCA - Regions02004006008001.0001.2001.4001.600199619

34、9820002002200420062008in 1,000ROWJapanUSAEuropa3374Extracorporeal Membrane Therapy - Oxygenation3054 blood (3-6l/min)O2 + CO2O2oxygenatorcardiotomydraining linesarterialfilter0066OxygenatorProduct Portfolio OxygenationOXYPHANPoly (propylene)OXYPLUS Poly (methylpentene)CELGARD X30-240Poly (propylene)

35、HEXPET heat exchangePoly (ethylene terephthalate)44481. spinning2. extraction3. drying and windingTemperature controlled air gapPolymerSolventGas N2Heated extruderGasMelted polymer and high temperature solventSpinneretProduction of OXYPHANHeat3042SEM of OXYPHAN0533Inner surface Cross sectionOuter su

36、rfaceProduction of Cross-wound Mat (Patented)3547Polyester warp threadOXYPHAN100 % visual inspectionCross-wound matAdvantages of Cross-wound MatUniform distribution of capillariesCapillaries fixed by warp threads (no movement)Open for various oxygenator designs (axial-, tangential-, crossflow etc.)B

37、loodfilm thickness (pressure drop) can be adjusted easilyEasy handling for oxygenator manufacturers (high yield)Closed capillary ends for safe potting3548HEX PETHeat EXchanger Capillary made from Polyester PET = Poly (ethylene terephthalate)Advantages for the patient/perfusionistbetter biocompatibil

38、ity when compared to steel heat exchangerstransparent design3376Membrana Partners in Oxygenation0886Membrane Industrial Specialities0473Technicalmembranes canbe found innumerousindustrialprocessesTechnical membranes are mostly used for microfiltrationCindy PearceAdministrative Asst.Ralf HornscheidtK

39、ey Acct. Mgr.Martin RueteringKey Acct. Mgr.Ute KorteInside Sales/ Cust Svc.Martina JacobInside Sales/ Cust Svc.Peter SteigerSales MgrIndustrialMembranesMisty McGuireMkt. Svcs.Beth KitteringhamMarketingMgrFred WieslerLMC AsiaKey Acct. Mgr.Jrgen SchneiderEuropean - LMCKey Acct. Mgr(75%)Brian MillerNA

40、LMCKey Acct. MgrTier 1Patrick McMurrayTech Svc. & LMCROW Inside SalesJorge MunozTech. Svc. &Bev. Acct. Dev.Hiroshi OmineLMC JapanKey Acct. Mgr.Yuji HirotaTeam Japan Mgr.(25%)Allen PittmannVP Sales & MarketingStatus: 12/01/2002Industrial SeparationsSales & Marketing Organization5082Membrana- Industrial SeparationsMicroporous Flat Sheet and Hollow Fiber Membranes FiltrationMembrane Contactors Degasification/Gas Absorption with liquids Water Low Surface Tension Fluids Other 5076Liqui-Cel Membrane ContactorThe Liquid flows on