恶性嗜铬细胞瘤的治疗ppt课件

1、Therapy of Malignant Pheochromocytoma恶性嗜铬细胞瘤的治疗恶性嗜铬细胞瘤的治疗Literature ReportIntroduction rule of 10s for pheochromocytoma (PCC) 10% bilateral 10% extra-adrenal 10% extra-abdomen 10% malignant 10% familial 10% children 10% normal blood pressureIntroductionThe most frequent site of metastases is the ske

2、letonAdditional sites are liver, retroperitoneum with lymph nodes, CNS, pleura, and kidneyMalignant vs. BenignCurrently, there is no effective cure for malignant pheochromocytoma.There are also no reliable histopathological methods for distinguishing benign from malignant tumors.Malignancy requires

3、evidence of metastases at non-chromaffin sites distant from that of the primary tumor.Metastatic disease in pheochromocytoma may be present at the time of initial diagnosis or may only became evident after surgical removal of the primary tumor, usually within 5 years, but sometimes 16 or more years

4、later.Due to the rarity of the tumor, clinical studies about pheochromocytoma suffer from a fragmented nature and usually involve too small a number of cases to reach conclusive results.Because there is currently no effective cure for malignant pheochromocytoma, most treatment are palliative, but in

5、 some cases may reduce tumor burden and prolong survival.Without treatment, the 5-year survival is generally less than 50%.The course, however, can be highly variable with occasional patients living more than 20 years after diagnosis.Once malignancy is diagnosed, therapy is generally directed at con

6、trolling blood pressure, but may also include tumor debulking.Alternative of Current TherapySurgeryRadiopharmaceuticalsCombined ChemotherapyArterial EmbolizationAlternative of Current TherapySurgeryRadiopharmaceuticalsCombined ChemotherapyArterial EmbolizationPrimary surgical resection is the treatm

7、ent of choice whenever possibleLimited disease: curative intentionExtended disease: still to be considered in the first place for debulking and as palliative treatment(Mundschenk et al. 1998)ProblemWhen signs of regional involvement or distant disease are absent, there is currently no reliable preop

8、erative diagnostic test that can differentiate between malignant and benign pheochromocytomas Should pheochromocytoma size influence surgical approach? A comparison of 90 malignant and 60 benign pheochromocytomas (Wen T. Shen et al.2004)Comparison of tumor size for benign pheochromocytomas and malig

9、nant pheochromocytomas with local disease only Size does not reliably predict malignancy in pheochromocytomas with local disease only Malignant (n = 29)Benign (n = 55)Tumor size (mean SD)6.1 3.1 cm5.3 2.3 cm2 cm012.0-3.9 cm9104.0-5.9 cm6256.0-7.9 cm5138.0-9.9 cm5310 cm43Malignant PCCs presenting wit

10、h only local disease cannot be discriminated from benign PCCs by size alone. When PCCs do not have evidence of invasion or distant metastases and the surgeon acquires an appropriate level of experience, the majority of these tumors can be safely resected laparoscopically. Laparoscopic adrenalectomy

11、for pheochromocytoma should be converted to open adrenalectomy for difficult dissection, invasion, adhesions, or surgeon inexperience Surgical approachTransabdominal approach is necessaryminimally invasive proceduresretroperitoneal approaches should be abandonedto definitely preserve the tumor capsu

12、le and perform total lymphadecectomy(Orchard et al. 1993)Secondary TumorsNo experience with adjuvant pre and postoperative radiation existsGenerally are multipleRadical surgical resection is often impossibleOther treatment modalities have to be consideredAlternative of Current TherapySurgeryRadiopha

13、rmaceuticalsCombined ChemotherapyArterial Embolization131I-MIBG is the treatment of choice for all unresectable, MIBG positive tumors58 cases of malignant PCC treated by 131I-MIBGtherapeutic results and adverse events(ZHU Ruisen et al. 1999)Patients were classified into 3 groups according to their t

14、umor size 20 cm3 (26 cases) In group 1, the mean absorption dose per gram of tumor was above 1 000 cGy. After treatment ,tumors disappeared or shrinked in all patients In group 2 , the absorption dose was similar to that of group 1, but the mean absorption dose per gram was 717.6 cGy , and tumor mas

15、s regression was 36 % ;76 % reduced urinary catecholamine In group 3 , the absorption dose per gram tumor tissue was 277 cGy , and 30 % tumor enlargement , 20 % died ; the remaining 50 % symptomatic improvement without any change in tumor size131 I-MIBG is of certain therapeutic effectiveness of sym

16、ptomatic improvementComplete tumor mass disappearance has only been found in small tumorsTreatment with 131 I-MIBG should be instituted immediately after surgical resection to eradicate the residual tumor cells and to prevent recurrencesBone marrow suppression is temporary and not dosage relatedIn 1

17、997, Loh et al. published a review of the worldwide experience involving 116 patients treated with 131I-MIBG for malignant pheochromocytoma. Overall, there was a symptomatic response in 76%, a hormonal response in 45%, and tumor regression in 30%. The activity of 131I-MIBG per single dose was 96300

18、mCi, and the mean cumulative activity was 490350 mCi.Only five CRs to 131I-MIBG were reported.LimitationsNot all patients with multiple metastases of malignant pheochromocytomas have sufficient uptake of MIBG to allow MIBG therapyMIBG negative lesions coexist with MIBG postive lesions, requiring com

19、bined treatmentAs a single agent,131I-MIBG has limited efficacy in treating malignant pheochromocytoma. Its use in combination with other cytotoxic agents, as is currently being studied in patients with neuroblastoma, may result in additional benefit(Sisson et al. 1999)Alternative of Current Therapy

20、SurgeryRadiopharmaceuticalsCombined ChemotherapyArterial EmbolizationOnly sparse data on chemotherapeutic regimens are available, most of them in reports of few casesThe most well-established regimen is CVD (Averbuch et al. 1988)CTX 750mg/m2 d1, VCR 1.4mg/m2 d1, Dacarbazine 600mg/m2 d1,2Cycle 21 day

21、sThe CVD regimen was based on the treatment for advanced neuroblastoma.This regimen has been reported to produce good responses in malignant pheochromocytoma, but the median duration of remission is 21 monthsComplete long-term disease remissions with chemotherapy have not been reported.Alternative o