臭氧大自血疗法介绍及开展状况(中英)

1、= 臭氧大自血疗法介绍及开展状况Introduction of Ozone Major Autohemotherapy and Its Development一、 国外开展的情况 Development Condition Abroad臭氧作为一种新兴的治疗手段在欧美已经越来越多的被医生们引起重视，在德国、西班牙医生们采用臭氧自血回输疗法治疗急性期中风患者，使患者致残率大大降低。在意大利许多医院和医生们用于急性椎间盘突出的治疗，取得了意想不到的效果。在古巴、俄罗斯医生们用臭氧水、臭氧油治疗烧、烫伤、糖尿病足，都获得巨大成功。世界臭氧协会、欧洲臭氧协会以及各个国家的臭氧协会纷纷成立，世界臭氧协会

2、分会中国臭氧协会于2008年9月5日成立。中国臭氧协会主席由南方医科大学附属南方医院何晓峰教授担任，与臭氧相关的学科，康复科、骨科、神经内科、传染科、烧伤科、皮肤科的专家教授参与此次大会，讨论交流这种新兴的十分有医学价值的诊疗手段。As a newly emerging treatment method, medical ozone therapy has been more and more brought to a forefront by doctors in Europe and America. Ozone auto blood transfusion therapy is adop

3、ted in treatment of acute phase stroke by doctors in Germany and Spain, which largely decreases patients disability rate. Many hospitals and doctors in Italy adopt ozone therapy in treating acute protrusion of intervertebral disc and it has achieved unexpected good results. In Cuba and Russia, docto

4、rs has achieved great success in burn and diabetic foot treatment with ozonized water and ozonized oil. International Ozone Association (IOA), European Ozone Association as well as other ozone associations in different countries are gradually established. The China Ozone Association, branch of Inter

5、national Ozone Association, is set up in Sept 5th, 2008. Directed by Professor Xiaofeng He from Nanfang Hospital, China Ozone Association attracts experts and professors from ozone application related departments, such as rehabilitation, orthopedics, neurology, infectious disease, burn, dermatology.

6、 This rising treatment is of great medical value.在这而后,三氧医学逐步从单一治疗椎间盘突出症发展到治疗骨科、肝病科、心脑血管科、烫伤科、糖尿病内分泌科、肿瘤科等临床科室的应用，三氧治疗也从微创介入向三氧大自血治疗的全面发展，中国科学院北京转化研究院（航空总医院）的安建雄教授在三氧自体血的规范化治疗做出了重要贡献。在国内三氧学术界逐渐形成了“南有何晓峰、北有安建雄”的格局。Thereafter, the application of ozone therapy has gradually developed from solely treatme

7、nt of intervertebral disc protrusion to clinical treatments in departments of orthopaedics, hepatopathy, cardiovascular, burn, diabetes, endocrinology as well as oncology. Ozone therapy has developed from interventional therapy to major autohemotherapy. In the aspect of standardized treatment of ozo

8、ne autohemotherapy, professor Jianxiong AN from Aviation General Hospital of China Medical University, Beijing Institute of Translational Medicine, Chinese Academy of Sciences, makes great contribution. A well-known pattern of “Xiaofeng HE from South, Jianxiong AN” is gradually formed in China ozone

9、 academic world.二、医用价值 Medical Value臭氧自血回输及其它疗法可应用于：Ozone autohemotherapy and other therapies are applicable in:1 脑中风。包括出血性脑中风和缺血性脑中风。通过治疗能明显改善患者急性期脑水肿。同以往常规的甘露醇治疗相比具有时间短、见效快的特点。同样也可用于脑膜炎、周围神经病。另外，对于康复期的患者可以非常好的改善其肢体功能，提高患者的生活质量。Cerebral apoplexy: hemorrhagic stroke and ischemic stroke.Acute phase o

10、f cerebral edema can be obviously improved through treatment. Compare with regular mannitol treatment, the ozone therapy is efficient within short time. This treatment can also be applied in treatment of meningitis and peripheral neuropathy. Besides, the ozone therapy can improve limb functions and

11、life quality for the patients who are in rehabilitation.2 高脂血症。国内外观察结果显示，治疗显效时间和有效率均明显优于他汀类药物，且没有任何副作用。Hyperlipidaemia (HLP)According to observations from domestic and abroad, the treatment effectual time and efficiency are obviously better than statins without any side effects.3 糖尿病。可以减少降糖药物治疗，对于糖尿

12、病引起的眼病、糖尿病足有很好的疗效。Diabetes mellitusOzone therapy helps reduce application of hypoglycemic agents and has good results on eye diseases and diabetic foot caused by diabetes.4 肝炎病。对于病毒性肝炎的治疗，疗效相当或弱优于干扰素、拉米夫定等抗病毒药物，但没有抗病毒药物的副作用，且费用较低。对急性肝炎的临床治疗，臭氧有好的退黄疸、降低转氨酶作用。对于酒精性肝炎、药物肝炎等均可有明显的疗效。HepatitisThe therape

13、utic effects of viral hepatitis equals to or slightly better than antiviral drugs such as interferon and lamivudine without any side effects. The ozone treatment is cost effective. In clinical treatment of acute hepatitis, the ozone therapy has a good curative effect in jaundice and aminotransferase

14、 reducing. Whats more, the curative result in alcoholic hepatitis and drug hepatitis treatment is clear. 5 脑外科手术脑水肿，疗效显著。Effective treatment in brain surgery of cerebral edema6 外科手术创伤部位。用臭氧水进行常规冲洗能明显促进刀口愈合。最令人可喜的是，伤口留下的疤痕非常轻。Surgical traumaRegular washing with ozonized water can clearly promote the

15、healing of the wound. What is exciting is the left scar is not obvious. 7 疼痛介入科。应用介入方式采取点位直接疗法治疗腰间盘、类风湿性关节炎、带状疱疹技术已经非常成熟并取得了非常好的疗效，很多医院专家老师专程去南方医科大学附属南方医院及首都医科大学附属宣武医院学习和交流这项技术。Pain and Intervention Therapy Department Direct point treatment technology is adopted in treating lumbar disc herniation, r

16、heumatoid arthritis and herpes zoster. Many medical school experts pay a special visit to Nanfang Hospital and Xuanwu Hospital for study and technology exchanges.8 皮肤科。应用臭氧自血回输疗法和臭氧水冲洗对例如带状疱疹、湿疹和一些真菌感染有奇效。Dermatological DepartmentWashing the skin infected by herpes zoster, eczema or fungus with ozon

17、ized water or ozone autohemotherapy has a miraculous effect.9 肿瘤科。由于臭氧能诱导人体产生多种细胞因子，如肿瘤坏死因子等，所以国外很多医疗机构将臭氧治疗作为抗肿瘤的一种辅助疗法，减轻放化疗患者的疼痛感，提升患者自身免疫力，并取得可喜效果。Oncology DepartmentOzone therapy serves as an adjuvant treatment in antineoplastic therapy to reduce patients pain feeling and improve their immunity

18、 in many foreign medical institutes since the ozone induces human body to produce multiple cytokines, such as tumor necrosis factor.另外，目前国际上已经承认的一种新的疾病叫做慢性疲劳综合症，简称CFS。白领阶层、相关工作人员、家庭主妇多发。目前唯一有效的办法即是臭氧自血回输疗法。病人经过一个疗程（10次）的治疗，症状消失，效果非常明显。In addition, a new disease, which is called Chronic Fatigue Syndr

19、ome (CFS), is acknowledged in the world. It mostly occurs to white-collars, office workers and housewives. At present, the only effective way for CFS is Ozone Autohemotherapy. After a courses treatment (10 times), the symptoms disappear with clear effects. 三、臭氧大自血疗法简介 Brief Introduction of Ozone Aut

20、ohemotherapy 什么是臭氧大自血疗法 What is Ozone Autohemotherapy?臭氧大自血疗法疗法是将50-150ml的自体血与适量抗凝剂和等量的治疗浓度的臭氧混合再回输入体内（整个过程大约需时8-10min），从而产生治疗作用的臭氧治疗方法。Ozone Autohemotherapy refers to a treatment method that combines 50-150ml blood drawn from human body with equivalent ozone in therapeutic concentration and appropr

21、iate amount anticoagulant, and transfusing into human body (the whole process takes 8-10 mins). 臭氧的治疗作用Therapeutic Effects of Ozone therapy1.强氧化作用 Strong oxidation2.促进血液循环作用 Promote blood circulation3.促进含氧血红蛋白向组织释放氧气从而提高氧代谢水平 Accelerate hemoglobin release oxygen into tissues and improve oxygen metab

22、olism. 4.免疫刺激及平衡作用 Immunostimulation and balancing effect5.广谱抗菌作用 Broad-spectrum antibacterial6.清除自由基作用 Free radicals eradicating 7.清除肿瘤细胞 Eliminating tumor cells（一）臭氧大自血疗法适应症 Indications for Ozone Autohemotherapy1、慢性缺血性疾病 Chronic ischemic disease动脉循环性疾病主要由于动脉粥样硬化引起的各个器官的疾病。Arterial circulation diso

23、rders: various organic disease caused by atherosclerosis. 脑动脉粥样硬化引起的缺血性脑病：TIA、脑梗塞、脑栓塞Ischemic encephalopathy caused by cerebral atherosclerosis: TIA, cerebral infarction, brain embolism.心脏粥样硬化引起的缺血性心脏病：冠心病、心绞痛、心梗、心肌供血不足等。Ischemic heart disease caused by atherosclerotic heart: coronary heart disease,

24、 angina, myocardial infarction, myocardial ischemia.外周动脉粥样硬化引起的缺血性外周血管疾病：下肢动脉硬化闭锁症、血管性间歇性跛行等。Ischemic peripheral vascular disease caused by peripheral atherosclerotic lesions: lower limb arteriosclerosis locked-in syndrome and intermittent claudication.肾动脉粥样硬化引起的缺血性肾脏疾病：继发性高血压、肾功能减退。Ischemic renal d

25、isease caused by atherosclerotic renal artery stenosis: secondary hypertension, renal hypofunction.肠系膜动脉粥样硬化引起的：肠道功能减退继发的各种疾病。Secondary diseases of intestinal function decline caused by mesenteric arteries2、急、慢性感染性疾病 Acute and chronic infectious disease 对于抗生素或化疗耐药细菌、病毒、真菌。甚至寄生虫感染，如：梨形鞭毛虫病、隐孢子虫病，在古巴医

26、生用臭氧油进行治疗。Antibiotics and chemotherapy drug resistant bacteria, virus and fungus, parasitic infection, such as giardiasis and cryptosporidiosis are treated by Cuban doctors with ozonized oil.3、紧急情况，如在大面积创伤、烧伤、急性腹膜炎、毒血症之后造成的多器官功能衰竭和死亡。联合最好的传统治疗和一天3至4次的臭氧大自体血疗法可以避免或降低代谢损伤的恶化，降低死亡率。另外，等待器官的病人可以在手术前在6至1

27、5天之间进行6至8次的臭氧大/小自体血疗法可以提高对于感染的抵抗力和改善免疫抑制（因为麻醉或外科手术）。同时可以减低器官移植后的缺血再灌流损伤。其他的一般手术也可以将臭氧治疗作为手术前的准备型治疗。 Ozone therapy can be applied in emergency circumstances, such as multiple organ failure and death caused by large area of trauma, burn, acute peritonitis, toxemias. Combining the ozone autohemotherapy

28、 for 3-4 times a day with traditional therapy could avoid or reduce the deterioration of metabolism and decrease the death rate. Whats more, patients who are waiting for organs transplant can take 6 to 8 times micro or macro ozone authohemotherapy in 6 to 15 days before operation, so as to increase

29、immunity to the infection and improve immunosuppression (caused by anesthesia or surgery). Ischemia and reperfusion injury after the organ transplantation can be reduced. Ozone therapy can also be used in other general surgery for preoperative treatment.4、骨髓炎、脓胸、腹膜炎、脓疮、褥疮、慢性溃疡、糖尿病足、烧伤、感染性伤口、念珠菌病、甲癣，

30、以上疾病经常伴有抗生素耐药细菌。如耐二甲氧基苯青霉素金色葡萄球菌，抗生素对于感染区域缺乏贯穿，和许多发生在许多发达国家的死亡病例都有联系。在这样病例，臭氧化的自体血回输疗法和局部使用臭氧化橄榄油或葵花籽油起到快速的抗菌作用，并且令人难以置信的加快伤口愈合。臭氧作为一种非常不稳定的气体可以被不饱和脂肪植物油化合为一种稳定的臭氧化物。当臭氧化油被涂在伤口创面的渗出液上，臭氧化油与生物分子反应，生成并释放稳定的过氧化氢。消毒作用和改善的氧化作用可以加速疤痕的形成。一般的传统的药膏经过会含有无用的抗生素和生长因子。臭氧化油一旦被人们知道、使用，必将对数以百万的患者起到极大的治疗作用。The disea

31、ses, such as osteomyelitis, empyema, peritonitis, fester, pressure ulcer, chronic ulcer, diabetic foot, burn, infectious wound, candidiasis, onychomycosis, are often accompanied with antibiotics drug resistance bacteria, such as resistance to dimethoxy benzene penicillium staphylococcus aureus. The

32、antibiotics cannot run through the infected areas, which is connected to the death case happened in many developed countries. In cases like this, ozonized autohemotherapy and partly usage of ozonized olive oil or sunflower seed oil can receive rapid antibacterial effect and promote wound healing. As

33、 a very unstable gas, ozone can be chemically combined into a stable ozonide by unsaturated fat vegetable oil. When applied onto the wound surface, ozonized oil reacts with biomolecules and produces and releases stable hydrogen peroxide. The disinfection and improved oxidation effect can accelerate

34、scar formation. Traditional unguent contains useless antibiotics and growth factors. Once the ozonized oil is known and used, it will bring great treatment effects for millions of patients.5、疱疹病毒感染（HHVI和II）、带状疱疹、乳头瘤病毒感染。使用肌肉内注射的小自体血臭氧疗法，作为一种字体疫苗，同时结合臭氧油的局部应用对于预防疱疹的复发非常有作用。这种方法，特别是当联合使用阿昔洛维时，可以治愈绝大部分

35、的疱疹感染病人。同时对于减低带状疱疹感染和感染之后的神经痛也有非常好的效果。 Herpes virus infection (HHV I and II), herpes zoster, infection of papovavirusAs an auto vaccine, combined with partly use of ozonized oil, macro ozone autohemotherapy with muscle injection is very effective in prevention of herpes recurrence. If it is used tog

36、ether with acyclovir, most of the herpes infected patients can be healed. Besides, it can also help reduce varicella-zoster virus infection and effective in lightening neuralgia.6、慢性肝炎和艾滋病感染Chronic hepatitis and AIDS infection7、自身免疫性疾病（痛风、多发性硬化、类风湿性关节炎、克隆病）。自体血疗法是非常令人鼓舞的。Autoimmune disease (gout, mu

37、ltiple sclerosis, rheumatoid arthritis, Crohns disease)Autohemotherapy is very inspiring. 8、退行性疾病。自体血疗法可以改善老年性痴呆早期的患者。Degenerative diseaseAutohemotherapy could help improve early stage Alzheimer disease.9、肺部疾病（肺气肿、哮喘、COPD、急性呼吸窘迫综合征）。Pulmonary disease (pulmonary emphysema, asthma, COPD, acute respira

38、tory distress syndrome) 10、对于COPD的治疗原理如下：A、血液回输，脂质氧化物可以作用内皮细胞表面，提高前列腺环素和NO的释放，而内皮缩血管肽I的释放被抑制。NO和亚硝基硫醇的释放促进血管舒张，而阴离子超氧化物的释放会造成血管紧缩，并且对血小板和内皮细胞产生负面影响；B、缺血组织氧输送的增强、抗氧化酶的加强、血红素加氧酶I中和慢性氧化应激。C、对于免疫系统刺激可以控制慢性肺部感染。通过臭氧治疗COPD可以达到良好的效果，包括改善呼吸系数和步行试验。The treatment principle of CODP: A. Through the treatment, l

39、ipid peroxide acts on the surface of endotheliocyte and increase the releasing of prostacyclin and NO, thus the releasing of endothelin-1 is restrained. The producing of NO and S-nitrosothiols will promote vasodilatation while the releasing of anionic superoxide will lead to vasoconstriction and hav

40、e a negative impact on platelets and endothelial cells.B. Ischemic tissues oxygen transportation and antioxidant enzyme ability will be strengthened; haem oxygenase I neutralize chronic oxidative stress.C. Stimulation on immune system helps control chronic pulmonary infection. Ozone treatment for CO

41、DP will achieve good results, including improve respiration coefficient and minute walking test.11、期肾病被慢性氧化应激加重，不能被传统药物控制，臭氧治疗稳定严重的功能障碍，提高病人的生活治疗。Renal disease in late stage cannot be controlled by traditional medicine because of chronic oxidative stress. The ozone therapy stabilizes the dysfunction

42、 and improves patients life quality.12、臭氧自体血回输疗法联合臭氧油的局部应用被证明对于代谢综合征非常有效，比如2型糖尿病患者的难治性慢性溃疡。Ozone autohemotherapy, combined with ozonized oil partly applied, is proved to be effective in metabolic syndrome treatment, such as refractory chronic ulcer of type 2 diabetes patient. 13、皮肤病（牛皮癣、异位性皮炎）。Derma

43、topathya (psoriasis, atopic dermatitis)14、化疗药耐药的转移癌、癌性疲劳。通过臭氧治疗可以提高病人的生活质量，但是不可以阻断癌症的发展。另一方面，外科手术之后臭氧治疗非常有效，不仅可以通过诱导抗氧化反应强化细胞毒药物的作用，而且可以降低化疗药的毒性。Metastatic cancer resisting to chemotherapeutic drugs and cancer fatigue.Although the cancerous development cannot be stopped, the ozone therapy will impro

44、ve patients life quality. On the other side, ozone therapy is very effective in postoperative treatment. This therapy can not only strengthen cytotoxic drugs effect by inducing the antioxidant response, but also decrease chemotherapeutic drugs toxicity.15、慢性疲劳综合征和纤纬肌痛。自体血疗法已经被发现对于大多数的病人有效。Chronic fa

45、tigue syndrome and firbre muscle pain It is found that the macro ozone autohemotherapy is effective among most of patients（二）臭氧大自血疗法禁忌症 Contraindications of Macro Ozone Autohemotherapy甲亢、葡萄糖-6磷酸脱氢酶（G-6PD）缺乏症、心肌梗塞发作、孕妇、血小板减少、凝血机制障碍、臭氧过敏、急性乙醇中毒、柑橘过敏等。四、医用臭氧大自血疗法发展史 Development History of Medical Ozone

46、 Autohemotherapy1.1857年德国的Werner von Siemens制造出第一种臭氧发生器。Werner von Siemens from Germany manufactures the first ozone generator in 1853.2.1870年德国C. Lender报道了第一例医用臭氧治疗性的进行血液疗法。C. Lender reported the first case that adopts medical ozone to carry out hematotherapy in Germany in 1870.3.1902年，J.H.Clarke&#

47、39;s A Dictionary of Practical Materia Medica（实用药物学辞典）的书中描述了很多成功应用臭氧水治疗贫血，癌症、糖尿病、流感、吗啡中毒、口疮、马钱子碱中毒、百日咳。J.H.Clarke's A Dictionary of Practical Materia Medica describes many successful cases that apply ozonized water into treatment of anemia, cancer, diabetes mellitus, influenza, morphinism, aphth

48、a, strychninism, and pertussis.4.在1911年，Dr. Noble Eberhart出版了"A Working Manual ofHigh Frequency Currents",他是Loyola大学生理治疗部门的主任，他同样应用臭氧治疗了结核病、贫血、萎黄病、百日咳、哮喘、支气管炎、花粉热、失眠、肺炎、糖尿病、痛风、梅毒。Dr. Noble Eberhart published A Working Manual ofHigh Frequency Currents in 1911. As the director of therapy dep

49、artment, Dr. Eberhart treats many diseases with ozone, such as tuberculosis, anemia, chloranemia, pertussis, asthma, bronchitis, pollenosis, insomnia, pneumonia, diabetes mellitus, gout, syphilis.5.1929年，一本叫臭氧和它的治疗作用在美国被出版，书中列出114种疾病以及如何应用臭氧去进行治疗，书的作者们是美国一些顶尖医院的学术权威。The Ozone and Its Therapeutic Eff

50、ect is published in the United States in 1929. In this book, 114 diseases relevant treatment method with ozone are listed. The authors of this book are most academic authorities in top hospitals of America.6.1953年开始，德国医生WOLF在工作应用臭氧，撰写医用臭氧，并且培养臭氧治疗的很多医生。Since 1953, Germany doctor Wolf begins to use o

51、zone and writes Medical Ozone and cultivate many doctors using ozone treatment.7.1957年，Dr. J. Hansler取得了臭氧发生器的专利，该专利推动了德国臭氧治疗学界的发展。现在德国有7000名医生在进行日常性臭氧治疗工作。Dr. J. Hansler got the patent of Ozone Generator, which promote the ozone therapy development in Germany in 1957. Nowadays, there are altogether

52、 more than 7,000 doctors are carrying out ozone therapy for daily treatment in Germany.8.1982年，德国心脑血管专家DR.WASSER.GERD应用臭氧大自体血回输疗法治疗急性脑中风，取得了非常良好的效果。In 1982, Germany cardiovascular Dr. Wasser Gerd treated acute cerebral apoplexy with the application of ozone macro autohemotherapy and received very go

53、od results.9.1990年，古巴人报道了应用臭氧治疗青光眼，结膜炎，色素性视网膜炎。It is reported that Cuba treated glaucoma, conjunctivitis and retinitis pigmentosa with ozone in 1990.10.1992年，俄罗斯人报道了他们应用臭氧浸润的盐水治疗烧伤取得了惊人的疗效。今天，臭氧大自血治疗在许多国家已经被承认。包括德国、法国、意大利、俄罗斯、罗马尼亚、捷克、波兰、匈牙利、保加利亚、埃及、以色列、日本、古巴、墨西哥、中国、美国的五个州等。It is reported that Russia

54、n adopted saline infiltrated in ozone to treat burn wound, which achieves surprising effects. At present, the ozone macro autohemotherapy has been recognized by many countries in the world, including Germany, France, Italy, Russia, Romania, Czech, Poland, Hungary, Bulgaria, Egypt, Israel, Japan, Cub

55、a, Mexico, China and USA. 五、臭氧大自血疗法国内外应用现状及其安全性Ozone Autohemotherapy Application status and Safety at Home and Abroad臭氧疗法在德国应用已有近百年的历史，从最初局部外用治疗感染性溃疡逐渐发展到以自血疗法为主的内科治疗。在德国、意大利、古巴、俄罗斯、西班牙等医生们采用臭氧自血回输疗法治疗急性期中风患者，使患者致残率大大降低。世界臭氧协会、欧洲臭氧协会以及各个国家的臭氧协会纷纷成立，世界臭氧协会分会中国臭氧协会于2008年9月5日成立。至2015年11月在我国除了超过几千家医院开展臭

56、氧治疗椎间盘突出以外，已有几百上千家医院开展以治疗慢性缺血性疾病及慢性肝炎为主的臭氧自体血回输疗法，取得了很好的社会效益和经济效益。It has been a hundred years for Germany applying ozone therapy, from infective ulcers treatment partly using ozone to internal medicine treatment by ozone autohemotherapy. Ozone auto blood transfusion therapy is adopted in treatment o

57、f acute phase stroke by doctors in Germany, Italy, Cuba, Russia and Spain, which largely decreases patients disability rate. International Ozone Association (IOA), European Ozone Association as well as other ozone associations in different countries are gradually established. The China Ozone Associa

58、tion, branch of International Ozone Association, is set up in Sept 5th, 2008. Till November 2015, there are thousands of hospitals in China that adopt ozone to treat intervertebral disc protrusion; hundreds of hospitals have operated ozone autohemotherapy in treatment of chronic ischemic diseases an

59、d chronic hepatitis. Exciting social effect and economic benefits are achieved.1980年，德国医疗界组织了644位专家对臭氧疗法进行了回顾性研究，他们将38475位病人进行的579238次的治疗结果进行了统计分析，发现只有40人次出现过副作用，其百分比为0.000007%,有些还是由于其他疾病的并发症间接导致的。德国每年平均有700万人次的臭氧自体血治疗，但无一例死亡或严重并发症，也无任何医疗纠纷。我国自2005年引进臭氧大自血疗法至今，已有超过十余万人次的治疗，但无一例医疗事故或纠纷发生。这一切均表明：臭氧疗法确实是最安全的。与其它治疗技术不良反应的发生