儿科12级纸质档课件16 measles

1、MEASLES Division Of Infectious Diseases And Gastroenterology l Acute respiratory infectious disease caused by measles virus l Clinical feature: Fever, Cough, Coryza, Conjunctivitis, Exanthem l Specific sign: Kopliks Spots Division Of Infectious Diseases And Gastroenterology : ssRNAvirus Family: para

2、myxoviridae Division Of Infectious Diseases And Gastroenterology Only one Patients respiratory secretions Blood, Urine of patients Characterization: 1. Sensitive to heat , ultraviolet light and disinfectant 2. Low temperature resistance Division Of Infectious Diseases And Gastroenterology infective

3、stage: lThe infective stage is from the late of incubation stage to the 5th day after rash eruption. lIf complication occurs, the infective stage prolongs to the 10th day after rash eruption. Infectious sources- Patients Division Of Infectious Diseases And Gastroenterology Routes of transmission Div

4、ision Of Infectious Diseases And Gastroenterology Population susceptibility l It is susceptible to all the people without infection or inoculation. l The age of peak incidence is from 6 months to 5 years old. Division Of Infectious Diseases And Gastroenterology Prior to the use of vaccineAfter the u

5、se of vaccine Morbidity (1/100000) Major epidemics: 500-1000 Mild epidemics: 400 9.5 in 1990 Peak seasonIn winter and springIn any time of a year Epidemic cycle Major epidemics appear by 2-4 yr intervals Longer cycle Sporadic cases increased Age6m-5y (98%10y)Below 6m and teenage Clinical manifestati

6、ons Typical cases severe manifestations more complications high mortality Atypical cases increased mild manifestations less complications rarely death Epidemiological Features Division Of Infectious Diseases And Gastroenterology Incubation period Apparent manifestations Respiratory epithelium region

7、al lymph nodes Primary viremia mononuclear phagocytic system Respiratory tract, conjunctiva, skin, etc Virus elimination secondary viremia Division Of Infectious Diseases And Gastroenterology Reported mechanisms of measles immune suppression. 1. Functional Impairment 1)Suppression of lymphocyte prol

8、iferation 2)Altered cytokine profiles 3)Lymphoproliferation defect due to MV-infected DC 4)Immune modulation mediated by viral proteins 5)Modulation of cell membrane components 6)Inhibition of hematopoiesis 2.Depletion 1)Lymphocyte infection treatment is entirely symptomatic and supportive. Division

9、 Of Infectious Diseases And Gastroenterology l What is the pathogen of measles? l What is the infection source? How is measles virus transmitted? l Who is the susceptible to measles? l How many times does a person suffer from measles in his lifetime? l What are the typical clinical manifestations of measles? What are the complications of measles? l How to