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1、directoryrichard brunoassociate professor, human nutritionrichard brunos vitae325 campbell hall campbell hall(614) 292-5522doctorate of philosophy in human nutrition, ohio state university; columbus, ohiomaster of science in human nutrition, university of delaware; newark, delawarebac

2、helor of science in applied nutrition; minor in biology, university of delaware; newark, delawareresearch interestsdr. richard bruno is a bionutritionist and registered dietitian with expertise in the areas of phytochemical and antioxidant utilization and metabolism in relation to free radical-media

3、ted toxicology. the research conducted in his laboratory aims to define the mechanisms regulating the bioavailability of phytochemicals, particularly vitamin e and polyphenols, and the mechanisms by which these dietary agents protect against oxidative stress and pro-inflammatory responses that other

4、wise contribute to vascular endothelial dysfunction and nonalcoholic steatohepatitis (nash). his work routinely utilizes obese experimental models and clinical populations having heightened oxidative stress and inflammatory responses with the underlying goal of translating experimental findings into

5、 practical recommendations that promote optimal health in humans.at present, studies led by his laboratory are directed at:1 improving the bioavailability of quercetin using dietary manipulations and quercetin-nanoemulsions,2 defining -tocopherol bioavailability and dietary requirements in individua

6、ls with metabolic syndrome,3 identifying the antioxidant and anti-inflammatory mechanisms of green tea during nash,4 defining the vasoprotective activities of -tocopherol supplementation during smoking cessation, and5 determining the vasoprotective activities of dairy ingestion in individuals with m

7、etabolic syndrome.grantsgreen tea confections for managing postprandial hyperglycemia-induced vascular endothelial dysfunctionsponsor: the ohio state university food innovation center (2013-2014) the goal of this product is to develop a novel green tea catechin containing confection that aims to att

8、enuate postprandial blood glucose and its associated effects that induce vascular endothelial dysfunction anti-inflammatory activities of green tea during obesity-induced nashsponsor: ohio agricultural research development center (2013-2015) the goal of this project is to better define the hepatopro

9、tective mechanisms by which green tea suppresses nfb activation in a diet-induced obese model of nash. dairy fat as a mediator of vitamin e adequacy in individuals with metabolic syndromesponsor: dairy research initiative (2012-2015)the goal of this project is to define -tocopherol bioavailability i

10、n response to dairy fat and evaluate dietary vitamin e requirements in individuals with metabolic syndrome. vasoprotective activities of low-fat milk in individuals with metabolic syndromesponsor: dairy research institute (2011-2013)the goal of this project is to define the acute vasoprotective effe

11、cts of low-fat milk ingestion on postprandial changes in vascular endothelial function and nitric oxide homeostasis in individuals with metabolic syndrome. cardioprotective synergy of smoking cessation and -tocopherol in restoring vascular endothelial functionsponsor: connecticut department of publi

12、c health (2011-2013)the goal of this project is to examine the extent to which dietary -tocopherol supplementation improves vascular function in combination with smoking cessation by lowering oxidative stress and pro-inflammatory responsespublicationssw leonard*, rs bruno*, e paterson, bc schock, j

13、atkinson, tm bray, ce cross, mg traber. (2003). 5-nitro-gamma-tocopherol increases in human plasma exposed to cigarette smoke in vitro and in vivo. free radic biol med, 35 (12): 1560-7. *both authors contributed equallyrs bruno, r ramakrishnan, tj montine, tm bray, mg traber. (2005). alpha-tocophero

14、l disappearance is faster in cigarette smokers and is inversely related to their ascorbic acid status. am j clin nutr; 81(1): 95-103.rs brunoand mg traber. (2005). cigarette smoke alters human vitamin e requirements. j nutr; 135(4): 671-4 (invited review).rs bruno, sw leonard, j li, tm bray, mg trab

15、er. (2005). lower plasma alpha-carboxyethyl-hydroxychroman after deuterium labeled alpha-tocopherol supplementation suggests decreased vitamin e metabolism in smokers. am j clin nutr; 81(5): 1052-9. (publication named by the nih to the top 25 dietary supplementation studies for 2005).rs bruno, sw le

16、onard, r ramakrishnan, j atkinson, tj montine, tm bray, mg traber. (2006). faster plasma vitamin e disappearance in smokers is normalized by vitamin c supplementation. free radic biol med; 40(4):689-97; epub nov 15 2005. (received commentary: buettner gr. (2006). commentary on faster plasma vitamin

17、e disappearance in smokers is normalized by vitamin c supplementation. free radic biol med; 40(4): 555-6).rs bruno, sw leonard, s-i park, y zhao, mg traber. (2006). human vitamin e requirements assessed with the use of apples fortified with deuterium-labeled -tocopheryl acetate. am j clin nutr; 83:

18、299-304.rs brunoand mg traber. (2006). vitamin e biokinetics, oxidative stress and cigarette smoking. pathophysiology; 13(3):143-9. (invited review).rs bruno, y song, sw leonard, dj mustacich, aw taylor, mg traber, e ho. (2007). dietary zinc restriction in rats alters antioxidant status and increase

19、s plasma f2-isoprostanes. j nutr biochem; 18(8): 509-18.rs bruno, ce dugan, ja smyth, da dinatale, si koo. (2008). green tea extract protects leptin-deficient, spontaneously obese mice from hepatic steatosis and injury. j nutr, 138(2):323-31.(received commentary: american society for nutrition (2008

20、). an international press release was issued that highlighted the findings of this investigation.aw taylor, rs bruno, mg traber. (2008). women and smokers have elevated urinary f2-isoprostane metabolites; determinations using a novel extraction and lc-ms methodology. lipids;43(10):925-36.dj mustachi

21、ch, k gohil, rs bruno, m yan, sw leonard, e ho, ce cross, mg traber. (2008). alpha-tocopherol modulates genes involved in hepatic xenobiotic pathways in mice. j nutr biochem; 20(6):469-76.am kenny, km mangano, rh abourizk, rs bruno, de anamani, a kleppinger, sj walsh, km prestwood, je kerstetter. (2

22、009). soy proteins and isoflavones affect bone mineral density in older women: a randomized controlled trial. am j clin nutr;90(1):234-42.ut iwaniec, rt turner, si koo, r kaur, e ho, cp wong, rs bruno. (2009). consumption of green tea extract results in osteopenia in growing mice. j nutr;139(10):191

23、4-9.(received commentary: american society for nutrition (2009). an international press release was issued that highlighted the findings of this investigation).m-y chung, sf yeung, hj park, js volek, rs bruno. (2010). dietary - and -tocopherol protect against lps-triggered hepatic injury in spontane

24、ously obese mice. j nutr biochem,21(12):1200-6.hj park, sr davis, h-y liang, dw rosenberg, rs bruno. (2010). chlorogenic acid differentially alters hepatic and small intestinal thiol redox status without protecting against azoxymethane-induced colon carcinogenesis in mice. nutr cancer, 62(3):362-370

25、.hj park, dd dinatale, m-y chung, j-y lee, si koo, rs bruno. (2011). green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice. j nutr biochem,22(4):393-400.hj park, e mah, rs bruno. (2010). validation of hplc-boron dope

26、d diamond detection for assessing hepatic glutathione redox status. anal biochem, 407(2):151-9.a hsu, rs bruno, cv loehr, rh dashwood, tm bray, and e ho. (2011). soy and tea inhibit chronic inflammation and nfkappab activation in hormone-induced prostate carcinogenesis in noble rats. j nutr biochem,

27、22(5):502-10.e mah, md matos, dm kawiecki, kd ballard, y guo, js volek, rs bruno. (2011). vitamin c status is related with pro-inflammatory responses and vascular endothelial function in healthy college-aged lean and obese men. j am diet assoc, 111(5):737-43.cp wong, lp nguyen, sk noh, tm bray, rs b

28、runo, e ho. (2011). induction of regulatory t cells by green tea polyphenol egcg. immunol lett, 139(1-2):7-13.e mah, sk noh, kd ballard, me matos, js volek, rs bruno. (2011). postprandial hyperglycemia impairs vascular endothelial function in healthy men by inducing lipid peroxidation and increasing

29、 asymmetric dimethylarginine/arginine. j nutr, 141(11):1961-8. (received commentary:american society for nutrition (2011). an international press release was issued that highlighted the findings of this investigation).my chung, hj park, m oconner, j manautou, rs bruno. (2012). green tea extract prot

30、ects against nonalcoholic steatohepatitis in ob/ob mice by decreasing oxidative and nitrative stress responses induced by pro-inflammatory enzymes. j nutr biochem, 23(4):361-7c masterjohn, e mah, y guo, si koo, rs bruno (2012). -tocopherol abolishes postprandial increases in plasma methyglyoxal foll

31、owing an oral dose of glucose in healthy, college-aged men. j nutr biochem,23(3):292-8.hj park, j-y lee, m-y chung, y-k park, am bower, si koo, c giardina, rs bruno. (2012). green tea extract suppresses nfb activation and inflammatory responses in diet-induced obese rats with nonalcoholic steatohepa

32、titis. j nutr, 142(1):57-63.c masterjohn and rs bruno. (2012). therapeutic potential of green tea on nonalcoholic fatty liver disease. nutr rev,70(1): 41-56. (invited review).e mah and rs bruno. (2012). postprandial hyperglycemia on vascular endothelial function: mechanisms and consequences. nutr re

33、s, 32(10): 727-40.e mah, sk noh, kd ballard, hj park, js volek, rs bruno. (2013). supplementation of a -tocopherol-rich mixture of tocopherols in healthy men protects against vascular endothelial dysfunction induced by postprandial hyperglycemia. j nutr biochem. 24(1):196-203.y guo, e mah, cg davis,

34、 t jalili, mg ferruzzi, ok chun, rs bruno. (2013). dietary fat increases quercetin bioavailability in overweight adults. mol nutr food res, e-pub jan 15.c masterjohn, e mah, y park, r pei, j lee, je manautou, rs bruno. (201x). acute glutathione depletion induces hepatic methylglyoxal accumulation by

35、 impairing its detoxification to d-lactate. exp biol med, in press.directorymark faillachair hn&cs/int dir paes, human nutritionprofessor, food science & technologymark faillas vitae262g campbell hall(614) 688-1444education b.s. chemistry, st. francis college, brooklyn, ny, 1970 m.s.

36、microbiology, indiana university, bloomington, in, 1975 ph.d. microbiology, indiana university, 1976interestsit has been estimated that the human diet contains approximately 20,000 unique compounds, although only 42 of these are classified as essential for life. laboratory, clinical and epidemiologi

37、cal studies consistently have suggested that many non-essential components of the diet are capable of modulating health. moreover, there is a rapidly increasing literature demonstrating that many tissues, as well as the resident bacteria colonizing the gut, convert numerous ingested compounds to met

38、abolites that affect the proliferation, differentiation and functions of various cells. identification of the bioactive compounds present in foods and the elucidation of their absorption, metabolism and molecular mechanisms of action continue to attract much interest in the biomedical sciences. insi

39、ghts are facilitating interactions among nutrition and food scientists, geneticists, plant and animal scientists, and physician/veterinary scientists, aimed at the development of new foods that promote health and can be used as adjuvants for the treatment of diseases. this truly is an exciting time

40、to be a nutrition scientist!our research team is interested in problems related to the digestive metabolism, intestinal cell uptake, absorption and functions of health promoting compounds in plant foods. our current project include investigations focused on carotenoids, soy isoflavonoids, anthocyani

41、ns and xanthones. we are particularly interested the following: a) the impact of plant genotype and traditional styles of cooking on pro-vitamin a bioavailability from biofortified cultivars of staple foods (e.g., cassava, maize, rice and sweet potato) that are the primary source of energy and nutri

42、ents for rural populations in developing countries; b) the influence of amount and type of dietary fat on the uptake of carotenoids and other fat soluble health-promoting compounds in foods and meals; and, c) the anti-inflammatory activities of various dietary compounds in the gastrointestinal tract

43、 and the influence of such compounds and their metabolites on interactions between gut bacteria and gut epithelial cells.we use in vitro approaches to simulate digestion and human intestinal cells to study the absorption, metabolism, and trans-epithelial transport (“absorption”) of bioactive compoun

44、ds by human intestinal cells. we also translate results from such in vitro studies using laboratory animal models, as well as interventions. we collaborate with outstanding colleagues at osu and other institutions to enhance the types of problems being investigated and to provide graduate students w

45、ith opportunities to broaden their conceptual and technical skills.publications walsh, k.r., haak, s.j., bohn, t., tian, q., schwartz, s.j., failla, m.l. (2007) isoflavonoid glucosides are deconjugated and absorbed in the small intestine of human subjects with ileostomies. am. j. clin. nutr. 85: 105

46、0-1056. pullakhandam, r., failla, m.l. (2007) micellarization and intestinal cell uptake of -carotene and lutein from drumstick (moringa oleifera) leaves. j. medicinal foods. 10: 252-257. bohn, t., tian, q.c., chitchumroonchokchai, c., failla, m.l., schwartz, s.j., cotter, r., waksman, j.a. (2007) s

47、upplementation of test meals with fat-free phytosterol products can reduce cholesterol micellarization during simulated digestion and cholesterol accumulation by caco-2 cells. j. ag. food chem. 55: 267-272. thakkar, s., maziya-dixon, b., dixon, a.g.o., failla, m.l. (2007) -carotene micellarization d

48、uring in vitro digestion and uptake by caco-2 cells is directly proportional to -carotene content in different genotypes of cassava. j. nutr. 137: 2229-2233. huo, t., ferruzzi, m.g., schwartz, s.j., failla, m.l. (2007) impact of fatty acyl composition and quantity of triglycerides on bioaccessibilit

49、y of dietary carotenoids. j. agr. food chem. 55: 8950-8957. winnick, j.j., w. michael sherman, w.m., diane l. habash, d.l.,stout, m.b., failla, m.l., belury, m.a., schuster, d.p. (2008) short-term aerobic exercise training in obese humans with type 2 diabetes mellitus improves whole body insulin sen

50、sitivity through gains in peripheral, not hepatic insulin sensitivity. j clin endocrinol metab 2008;93 771-778 failla, m.l., huo, t., thakkar, sk. (2008) in vitro screening of relative bioaccessibility of carotenoids from foods. asian pacific j. clin. nutr. 17 (s1): 200-203. failla, m.l., chitchumro

51、onchokchai, c., ishida, b. (2008) in vitro micellarization and intestinal cell uptake of cis isomers of lycopene exceed those of all-trans lycopene. j. nutrition 138: 482-486. long, a., agler, a., colitz, c., failla, m., bomser, j. (2008) isolation and characterization of primary canine lens epithel

52、ial cells. veterinary ophthalmology 11: 38-42. ornelas-paz, j., failla, m.l. yahia, e.l., gardea-bejar, a. (2008) the impact of stage of ripening and dietary fat on in vitro bioaccessibility of -carotene in ataulfo mango. j. agr. food chem. 56: 1511-1516. thakkar, s., failla, m.l. (2008) bioaccessib

53、ility of pro-vitamin a carotenoids is minimally affected by non-pro-vitamin a xanthophylls in maize (zea mays sp.). j. agr. food chem., 56: 11441-46. mills, j.p., tumuhimbise, g.a., jamil, k.m., thakkar, s.k., failla, m.l., tanumihardjo s.a. (2009) sweet potato -carotene bioefficacy is enhanced by d

54、ietary fat and not reduced by soluble fiber intake in mongolian gerbils. j. nutr., 139: 44-50. walsh, k.r., haak, s.j., fastinger, n.d., bohn, t., tian, q., mahan, d.c., schwartz, s.j., failla, m.l. (2009) gastrointestinal metabolism and absorption of soy isoflavonoids in ileal canulated swine. mole

55、cular nutr. food res. 53: 277-286. bumrungpert, a., kalpravidh, r.w., suksamrarn, s., chaivisuthangkura, a., chitchumroonchokchai, c., failla, m.l. (2009) bioaccessibility, biotransformation and transport of alpha-mangostin from garcinia mangostana (mangosteen) using simulated digestion and caco-2 h

56、uman intestinal cells. molecular nutr. food res. 53: 54-61. thakkar, s.k., huo, t., maziya-dixon, b. failla, m.l. (2009) impact of style of processing on retention and bioaccessibility of -carotene in cassava (manihot esculanta, crantz). j. ag. food chem. 57: 1344-1348. he, j., wallace, t., keatley,

57、 k., failla, m., giusti, m.m. (2009) stability of black raspberry anthocyanins in the digestive tract lumen and transport efficiency into gastric and small intestinal tissues in the rat. j. agr. food chem. 57: 3141-3148. walsh, k.r., failla, m.l. (2009) transport and metabolism of equol by caco-2 hu

58、man intestinal cells. j. agr. food chem. 57: 8297-302. failla, m.l., thakkar, s.k., kim, j.y.(2009) in vitro bioaccessibility of beta-carotene in orange fleshed sweet potato (ipomoea batatas, lam.). j. agr. food chem. 57: 10922-10927. tuntipopipat, s., muangnoi, c., failla, m.l. (2009) anti-inflamma

59、tory activities of extracts of thai spices and herbs with lps-activated raw 264.7 murine macrophages. j. medicinal foods, 12: 12131220. polara-cabrera k, huo t., schwartz s.j., failla, m.l. (2010) digestive stability and transport of norbixin, a 24-carbon carotenoid, across monolayers of caco-2 cells. j. agr. food chem., 58:57