食欲调控-外周、中枢与应激

1、食欲调控-外周、中枢与应激 Appetite Regulation-Peripheral, Central and the Role of Stress 山东农业大学动物科技学院 Richards MP, Proszkowiec-Weglarz M. 2007. Mechanisms regulating feed intake, energy expenditure, and body weight in poultry. Poult Sci. 86:1478-90. Hormonal regulation of appetite Orexin （食欲素）（食欲素） Leptin(瘦素瘦素)

2、 Insulin(胰岛素胰岛素) Adiponectin (脂联素脂联素 ) Ghrelin（生长素）（生长素） PYY PP(胰多肽) GLP-1 (胰高血糖素样肽1) OXM(胃泌酸调节素) CCK(胆囊收缩素) Stanley S, Wynne K, McGowan B, Bloom S. 2005. Hormonal regulation of food intake. Physiol Rev. 85: 1131-58. Nutrient regulation of feed intake Fatty acid (脂肪酸脂肪酸) Glucose (葡萄糖葡萄糖) Amino acid

3、(氨基酸氨基酸) Carol K.L. Lam, Madhu Chari and Tony K.T.Lam. 2009. CNS regulation of glucose homeostasis. Physiology. 24: 159-170. Tony K.T. Lam, Gary J. Schwartz and Luciano Rossetti. 2005. Hypothalamic sensing of fatty acids. Nature Neuroscience. 8: 579-584. Cota D, Proulx K, Smith KA, Kozma SC, Thomas

4、G, Woods SC, Seeley RJ. 2006. Hypothalamic mTOR signaling regulates food intake. Science. 312: 927-30. Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferr P, Birnbaum MJ, Stuck BJ, Kahn BB. 2004. AMP-kinase regulates food intake by responding to hormonal and nutrient sig

5、nals in the hypothalamus. Nature. 428: 569-74. Richards MP, Proszkowiec-Weglarz M. 2007. Mechanisms regulating feed intake, energy expenditure, and body weight in poultry. Poult Sci. 86:1478-90. Fig. 1a. Effect on AMPK mRNA expression AMPK 1AMPK 2LKB1 Relative mRNA level (as of 7 d) 0.0 .2 .4 .6 .8

6、1.0 1.2 1.4 1.6 1.8 7d 8d 9d a a b a b b a b a Effects of feeding ad lib (7d), fasting (8d) and refeeding (9d) on hypothalamic AMPK and (an)orexigenic peptide mRNA levels Z. Song, L. Liu, H. Lin, E. Decuypere and J. Buyse. 2010. Fasting induces an increase in AMPK2 gene expression in the hypothalamu

7、s of broiler chicks. Meeting abstract, Pama, Italy. Shimizu H, Arima H, Ozawa Y, Watanabe M, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. 2010. Glucocorticoids increase NPY gene expression in the arcuate nucleus by inhibiting mTOR signaling in rat hypothalamic organotypic cultures. Peptides. 31

8、: 145-9. Shimizu H, Arima H, Ozawa Y, Watanabe M, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. 2010. Glucocorticoids increase NPY gene expression in the arcuate nucleus by inhibiting mTOR signaling in rat hypothalamic organotypic cultures. Peptides. 31: 145-9. Lei Liu, Lixian Zhu, A. Sheikh Ahm

9、adi, Zhigang Song, Hongchao Jiao, Hai Lin. 2010. Heat stress and corticosterone contribute differently to the expression of appetite-related genes in laying hens. Poult. Sci. (submitted) Lei Liu, Lixian Zhu, A. Sheikh Ahmadi, Zhigang Song, Hongchao Jiao, Hai Lin. 2010. Heat stress and corticosterone contribute differently to the expression of appetite-related genes in laying hens. Poult. Sci. (submitted) 研究