00Introduction.ppt

1、Pathology,Second Edition Editor in chief: CHEN Jie and LI Gandi Peoples Medical Publishing House,Textbook,Introduction to pathology,Peking Union Medical College Chen Jie,Introduction to pathology,A bridging discipline involving both basic science and clinical practice. Devoted to the study of the st

2、ructural and functional changes in cells, tissues and organs that underlie disease. To explain the whys and wherefores of the signs and symptoms of the patients. Providing a sound foundation for rational clinical care and therapy.,Pathology,The study of etiology of the disease The study of pathogene

3、sis of disease The study of morphological changes of disease The most important diagnosis in modern medical practice The important step in evidence-based medicine The functional consequences of the morphologic changes (clinical significance),Pathology,Biopsy Histopathology Cytology Electromicroscopy

4、 Resected specimens Histochemistry Autopsy Microbiology Cell & tissue culture immunohistochemistry Molecular pathology,Etiology,Intrinsic or genetic Acquired infectious nutritional chemical physical,Pathogenesis,Initial stimulus - ultimate expression of disease Defective gene - cysts and fibrosis,Mo

5、rphologic changes,Structural alterations cells tissues organs Characteristic of the disease Diagnostic of the etiologic process,Clinical significance,Functional abnormality Clinical features (symptoms and signs) Clinical course Prognosis of the disease,“As is our pathology, so is our medicine”“病理为医之本”,Sir William Osler 1849-1919,基础医学课目中与临床最接近的当推病理学，因