Sintilimab-Anti-PD-1-IBI308-Anti-PD-1-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemESintilimab(Anti-PD-1)Cat.No.:HY-P99048ASynonyms:IBI308(Anti-PD-1)作⽤靶点:PD-1/PD-L1作⽤通路:Immunology/Inflammation储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Sintilimab(Anti-PD-1)(IBI308(Anti-PD-1))⼀种安全有效的⼈的IgG4单克隆抗体，与PD-1结合，其KD值为74pM。Sintilimab(Anti-PD-1)阻断PD-1与其配体(PD-L1和PL-L2)的相互作⽤，从⽽有助于恢复内源性抗肿瘤T细胞反应。Sintilimab(Anti-PD-1)联合益⽣元抑制肺腺癌⼩⿏肿瘤体积，调节免疫细胞亚群平衡。Sintilimab(Anti-PD-1)可⽤于经典霍奇⾦淋巴瘤、⾮⼩细胞肺癌和⾷管癌的研究[1][2][3][4][5]体外研究Sintilimab(150ng/μL,12h)showsahighlevelofPD-1occupancyandhassuperiorTcellactivatingcharacteristicsinhumanperipheralbloodmononuclearcells(PBMCs)[2]。体内研究Sintilimab(0.1mg/kg,1mg/kgand10mg/kg,i.p.,asingledosefor1,8,12,15days)showsantitumoreffectsagainstNCI-H292tumorsinahumanizedmousemodel[2].Sintilimab(1mg/kg,3mg/kgand10mg/kg,s.c.,asingledose)demonstratesahighaffinityforPD-1moleculesinNCI-H292tumor-bearingNOGmice[2].Sintilimab(20mg/kg,i.p.,onceinterval2daysfor21days)combinedwithprebioticsinhibitsthevolumeoftransplantedtumorsinlungadenocarcinomaandalleviatestheliverandkidneyinjury[4].PharmacokineticparametersofSintilimab(10mg/kg,i.v.,asingledose)inhPD-1knock-inmouse[2]ParameterAUC0-4(h·μg/mL)AUCinf(h·μg/mL)CL(mL/h)Cmax(μg/mL)T1/2(h)Vss(mL)Sintilimab6597.8887846.5540.025218.51935.6231.262REFERENCES[1].SheridanMHoy.Sintilimab:FirstGlobalApprovalDrugs.2019Feb;79(3):341-346.[2].WangJ,etalDurableblockadeofPD-1signalinglinkspreclinicalefficacyofsintilimabtoitsclinicalbenefit.MAbs.2019Nov-1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEDec;11(8):1443-1451.[3].ZhangL,etal.Sintilimab:APromisingAnti-TumorPD-1Antibody.FrontOncol.2020Nov26;10:594558.[4].YanQ,etal.PrebioticsModulateGutMicrobiota-mediatedT-cellImmunitytoEnhancetheInhibitoryEffectofSintilimabinLewisLungAdenocarcinomaModelMice.AnticancerAgentsMedChem.2023;23(17):1966-1973.[5].ZhangL,etal.Sintilimabforthetreatmentofnon-smallcelllungcancer.BiomarkRes.2022Apr18;10(1):23.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchu