Hypoglycemic-agent-3-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEHypoglycemicagent3Cat.No.:HY-170692分⼦式:C₃₂H₅₁NO₅分⼦量:529.75作⽤靶点:Akt;PI3K;NF-κB作⽤通路:PI3K/Akt/mTOR;NF-κB储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Hypoglycemicagent3(CompoundH26)，科罗索酸衍⽣物，具有降脂和显著的降⾎糖作⽤，可作为⼀种降⾎糖剂。Hypoglycemicagent3通过靶向MCCC1来抑制胰岛素抵抗，可以⽤于⼆型糖尿病的研究[1]。体外研究Hypoglycemicagent3(CompoundH26)(40-320μM;24h)showsnosignificantcytotoxicityinHepG2cells[1].Hypoglycemicagent3(20-40μM)suppressesinsulinresistanceprimarilybyincreasingMCCC1inHepG2cells[1].Hypoglycemicagent3(20μM;1h)significantlyinhibitstheincreaseinglucoseproductioninducedbyglucosamine(18mM;18h)(HY-B1125)inHepG2cells[1].Hypoglycemicagent3(2.5-20μM;1h)canactivatePI3K-AKTandinhibitNF-κBsignalingpathwayinHepG2cells[1].WesternBlotAnalysis[1]CellLine:HepG2Concentration:2.5,10,20μMIncubationTime:1hResult:EhancedthephosphorylationlevelsofKTandGSK3β.SgnificantlyincreasedtheexpressionofIκBα,suggestingthatH26mayinhibittheactivationofNF-κB.REFERENCES[1].HuangG,etal.CorosolicacidanditsderivativestargetingMCCC1againstinsulinresistanceandtheirhypoglycemiceffectontype2diabeticmice[J].EuropeanJournalofMedicinalChemistry,2024:117184.McePdfHeight1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792