Mitotane-13C12-2-4-DDD-sup-13-sup-C-sub-12-sub-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEMitotane-13C12Cat.No.:HY-13690S3CASNo.:2483736-36-1Synonyms:2,4′-DDD-13C12;o,p'-DDD-13C12分子式:C₂₁₃C₁₂H₁₀Cl₄分子量:331.95作用靶点:Isotope-LabeledCompounds;Apoptosis作用通路:Others;Apoptosis储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 Mitotane-13C12(2,4′-DDD-13C12)是13C标记的Mitotane。Mitotane(2,4’-DDD)是DDD的同分异构体和DDT的衍生物，有抗癌活性，可用于研究肾上腺皮质癌。Mitotane的肾上腺皮质溶解作用至少部分是通过细胞内游离胆固醇(FC)积累引起的脂毒性。Mitotane可对促皮质激素细胞产生直接垂体作用。Mitotane可通过类固醇和外源性受体(SXR)激活诱导CYP3A4基因表达，并存在活性分子-活性分子相互作用。REFERENCESRussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019Feb;53(2):211-216.TakeshitaA,Igarashi-MigitakaJ,KoibuchiN,MitotaneinducesCYP3A4expressionviaactivationofthesteroidandxenobioticreceptor.JEndocrinol.2013Feb15;216(3):297-305.DoghmanM,etal.Lackoflong-lastingeffectsofmitotaneadjuvanttherapyinamousexenograftmodelofadrenocorticalcarcinoma.MolCellEndocrinol.2013Dec5;381(1-2):66-9.ZatelliMC,etal.Therapeuticconcentrationsofmitotane(o,p'-DDD)inhibitthyrotrophcellviabilityandTSHexpressionandsecretioninamousecelllinemodel.Endocrinology.2010Jun;151(6):2453-61.WardeKM,etal.MitotaneTargetsLipidDropletstoInduceLipolysisinAdrenocorticalCarcinoma.Endocrinology.2022Sep1;163(9):bqac102.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>