Piperin-d10-Bioperine-d-sub-10-sub-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEPiperin-d10Cat.No.:HY-W654320Synonyms:Bioperine-d10;1-Piperoylpiperidine-d10分子式:C₁₇H₉D₁₀NO₃分子量:295.4作用靶点:Isotope-LabeledCompounds;EndogenousMetabolite;P-glycoprotein;Autophagy作用通路:Others;MetabolicEnzyme/Protease;MembraneTransporter/IonChannel;Autophagy储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 Piperin-d10是氘代标记的Piperine。Piperine是能够从胡椒中分离的天然生物碱，可以抑制P-glycoprotein和CYP3A4的活性。Piperine对HeLa细胞的IC50为61.94±0.054μg/mL。REFERENCESRussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019Feb;53(2):211-216.PaarakhPM,etal.InvitrocytotoxicandinsilicoactivityofpiperineisolatedfromPipernigrumfruitsLinn.InSilicoPharmacol.2015Dec;3(1):9.Epub2015Oct29.MeghwalM,etal.Pipernigrumandpiperine:anupdate.PhytotherRes.2013Aug;27(8):1121-30.LiC,etal.Non-linearpharmacokineticsofpiperineanditsherb-druginteractionswithdocetaxelinSprague-Dawleyrats.JPharmBiomedAnal.2016Sep5;128:286-93.ZhaiWJ,etal.PiperinePlaysanAnti-InflammatoryRoleinStaphylococcusaureusEndometritisbyInhibitingActivationofNF-κBandMAPKPathwaysinMice.EvidBasedComplementAlternatMed.2016;2016:8597208.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax: