Piribedil-maleate-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEPiribedilmaleateCat.No.:HY-12707BCASNo.:937719-94-3分⼦式:C₂₀H₂₂N₄O₆分⼦量:414.41作⽤靶点:DopamineReceptor;AdrenergicReceptor;HistoneMethyltransferase作⽤通路:GPCR/GProtein;NeuronalSignaling;Epigenetics储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Piribedilmaleate⼀种有效且具有⼝服活性的多巴胺D2(dopamineD2)和多巴胺D3(dopamineD3)激动剂。Piribedilmaleate也⼀种α2-肾上腺素受体(α2-adrenoceptors)拮抗剂。Piribedilmaleate可抑制MLL1甲转移酶的活性(EC50:0.18μM)。Piribedilmaleate可⽤于研究帕⾦森病，循环系统疾病，癌症。户使⽤本产品发表的科研⽂献•FrontChem.26July2022.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].SweetRD,etal.Piribedil,adopamineagonist,inParkinson'sdisease.ClinPharmacolTher.1974Dec;16(6):1077-82.[2].GerlachM,etal.TheeffectofpiribedilonL-DOPA-induceddyskinesiasinaratmodelofParkinson'sdisease:differentialroleofα(2)adrenergicmechanisms.JNeuralTransm(Vienna).2013Jan;120(1):31-6.[3].SmithLA,Tetal.RepeatedadministrationofpiribedilinduceslessdyskinesiathanL-dopainMPTP-treatedcommonmarmosets:abehaviouralandbiochemicalinvestigation.MovDisord.2002Sep;17(5):887-901.[4].XiongZhang,etal.PiribedildisruptstheMLL1-WDR5interactionandsensitizesMLL-rearrangedacutemyeloidleukemia(AML)todoxorubicin-inducedapoptosis.CancerLett.2018Sep1;431:150-160.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792