Encequidar-hydrochloride-HM30181-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEEncequidarhydrochlorideCat.No.:HY-13646BCASNo.:849675-88-3Synonyms:HM30181hydrochloride;HM30181Ahydrochloride分⼦式:C₃₈H₃₇ClN₆O₇分⼦量:725.19作⽤靶点:P-glycoprotein作⽤通路:MembraneTransporter/IonChannel储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Encequidarhydrochloride(HM30181hydrochloride)⼀种⼝服P-glycoprotein(P-gp)抑制剂，具有增强P-gp底物药物的⼝服⽣物利⽤度活性。Encequidar在多种MDR1抑制剂中显⽰出最⾼的效⼒，IC50=0.63nM。Encequidar有效阻⽌了在MDCK单层细胞中的紫杉醇的跨上⽪运输，IC50=35.4nM。户使⽤本产品发表的科研⽂献•NatCommun.2021Jan12;12(1):312.•EMBOJ.2024Aug19.•HepatolCommun.2024May2;8(5):e0437.•CritRevAnalChem.2021Mar10;1-15.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].BauerF,etal.InteractionofHM30181withP-glycoproteinatthemurineblood-brainbarrierassessedwithpositronemissiontomography.EurJPharmacol.2012Dec5;696(1-3):18-27.[2].KimTE,etal.EffectsofHM30181,aP-glycoproteininhibitor,onthepharmacokineticsandpharmacodynamicsofloperamideinhealthyvolunteers.BrJClinPharmacol.2014Sep;78(3):556-64.[3].Oraldocetaxelplusencequidar-aphase1clinicaltrialMcePdfHeight1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021-