Wortmannin-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEWortmannin(Standard)Cat.No.:HY-10197RCASNo.:19545-26-7分⼦式:C₂₃H₂₄O₈分⼦量:428.43作⽤靶点:Organoid;PI3K;Polo-likeKinase(PLK);Autophagy;Antibiotic作⽤通路:StemCell/Wnt;PI3K/Akt/mTOR;CellCycle/DNADamage;Autophagy;Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Wortmannin(Standard)Wortmannin的分析标准品。本产品⽤于研究及分析应⽤。Wortmannin(SL-2052)抑制剂，IC50值为3nM。Wortmannin(SL-2052)阻断⾃噬(autophagy)形成，并有效抑制Polo-likekinase1(PlK1)和Plk3，IC50值分别为5.8和48nM。IC50&TargetIC50:3nM(PI3K),200nM(MLCK)[1]IC50:16nM(DNA-PK),150nM(ATM),1.8μM(ATR)[2]REFERENCES[1].YanoH,etal.Inhibitionofhistaminesecretionbywortmanninthroughtheblockadeofphosphatidylinositol3-kinaseinRBL-2H3cells.JBiolChem.1993Dec5;268(34):25846-56.[2].MoonEK,etal.AutophagyinhibitorsasapotentialantiamoebictreatmentforAcanthamoebakeratitis.AntimicrobAgentsChemother.2015Jul;59(7):4020-5.[3].LiuY,etal.Polo-likekinasesinhibitedbywortmannin.Labelingsiteanddownstreameffects.JBiolChem.2007Jan26;282(4):2505-11.[4].WuQ,etal.WortmannininhibitsK562leukemiccellsbyregulatingPI3k/Aktchannelinvitro.JHuazhongUnivSciTechnologMedSci.2009Aug;29(4):451-6.[5].LemkeLE,etal.Wortmannininhibitsthegrowthofmammarytumorsdespitetheexistenceofanovelwortmannin-insensitivephosphatidylinositol-3-kinase.CancerChemotherPharmacol.1999;44(6):491-7.[6].LiuY,etal.Wortmannin,awidelyusedphosphoinositide3-kinaseinhibitor,alsopotentlyinhibitsmammalianpolo-likekinase.ChemBiol.2005Jan;12(1):99-107.[7].PobbatiAV,etal.AcombatwiththeYAP/TAZ-TEADoncoproteinsforcancertherapy.Theranostics.2020Feb18;10(8):3622-3635.McePdfHeight1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-