Tacrolimus-monohydrate-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemETacrolimusmonohydrate(Standard)Cat.No.:HY-13756ARCASNo.:109581-93-3分⼦式:C₄₄H₇₁NO₁₃分⼦量:822.03作⽤靶点:Phosphatase;FKBP;Autophagy;Bacterial;Antibiotic作⽤通路:MetabolicEnzyme/Protease;Apoptosis;Autophagy;CellCycle/DNADamage;Immunology/Inflammation;Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Tacrolimus(monohydrate)(Standard)Tacrolimus(monohydrate)的分析标准品。本产品⽤于研究及分析应⽤。Tacrolimusmonohydrate(FK506monohydrate)⼤环内酯类化合物，Tacrolimusmonohydrate与FK506结合蛋⽩(FKBP)结合形成复合物并抑制钙调神经磷酸酶(calcineurinphosphatase)，从⽽抑制T淋巴细胞信号转导和IL-2转录。具有强免疫抑制特性。IC50&TargetPP2B(calcineurinphosphatase)[1]Autophagyinducer[2]REFERENCES[1].ThomsonAW,etal.ModeofactionofTacrolimus(FK506):molecularandcellularmechanisms.TherDrugMonit.1995Dec;17(6):584-91.[2].VogelKR,etal.mTORinhibitorsrescueprematurelethalityandattenuatedysregulationofGABAergic/glutamatergictranscriptioninmurinesuccinatesemialdehydedehydrogenasedeficiency(SSADHD),adisorderofGABAmetabolism.JInheritMetabDis.2016Nov;39(6):877-886.[3].ZhuH,etal.TacrolimuspromoteshepatocellularcarcinomaandenhancesCXCR4/SDF1αexpressioninvivo.MolMedRep.2014Aug;10(2):585-92.[4].OkadaY,etal.Tacrolimusamelioratesdextransulfatesodium-inducedcolitisinmice:implicationofinterferon-γandinterleukin-1βsuppression.BiolPharmBull.2011;34(12):1823-7.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955