Jatrorrhizine-chloride-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEJatrorrhizinechloride(Standard)Cat.No.:HY-N0740RCASNo.:6681-15-8分⼦式:C₂₀H₂₀ClNO₄分⼦量:373.83作⽤靶点:Cholinesterase(ChE);5-HTReceptor;Bacterial作⽤通路:NeuronalSignaling;GPCR/GProtein;Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Jatrorrhizine(chloride)(Standard)Jatrorrhizine(chloride)的分析标准品。本产品⽤于研究及分析应⽤。Jatrorrhizinechloride从连中分离得到的⽣物碱，具有神经保护、抗、抗疟原⾍和抗氧化活性。Jatrorrhizinechloride有效的，具有⼝服活性的⼄酰胆碱酯酶(AChE)(IC50=872nM)的抑制剂，对BuChE的选择性为115倍。Jatrorrhizinechloride通过抑制uptake-2transporter的活性减少⾎素(5-HT)和去甲肾上腺素(NE)的摄取。IC50&TargetIC50:872nM(AChE)[1]REFERENCES[1].SunS,etal.Jatrorrhizinereduces5-HTandNEuptakeviainhibitionofuptake-2transportersandproducesantidepressant-likeactioninmice.Xenobiotica.2019Oct;49(10):1237-1243.[2].XiaofeiJiang,etal.SynthesisandBiologicalEvaluationofNovelJatrorrhizineDerivativeswithAminoGroupsLinkedatthe3-PositionasInhibitorsofAcetylcholinesterase.ResearchArticleVolume2017[3].CWWright,etal.Invitroantiplasmodial,antiamoebic,andcytotoxicactivitiesofsomemonomericisoquinolinealkaloids.JNatProd.2000Dec;63(12):1638-40.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021