Itraconazole-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEItraconazole(Standard)Cat.No.:HY-17514RCASNo.:84625-61-6分子式:C₃₅H₃₈Cl₂N₈O₄分子量:705.63作用靶点:Fungal;Hedgehog;CytochromeP450;Autophagy;Antibiotic;Bacterial作用通路:Anti-infection;StemCell/Wnt;MetabolicEnzyme/Protease;Autophagy储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Itraconazole(Standard)是Itraconazole的分析标准品。本产品用于研究及分析应用。Itraconazole(R51211)是一种三唑类抗真菌药，也是一种有效的口服活性的Hedgehog信号通路拮抗剂，IC50约为800nM。Itraconazole可有效抑制羊毛甾醇14α-脱甲基酶(CytochromeP450)，从而抑制羊毛甾醇向麦角固醇的氧化转化。Itraconazole具有抗癌和抗血管生成作用。Itraconazole也是一种oxysterol-bindingprotein(OSBP)抑制剂。IC50&TargetFungal[1]IC50:~800nM(Hedgehogsignalingpathway)[1]14α-demethylase(cytochromeP450enzyme)[3]REFERENCESKim,J.,etal.,Itraconazole,acommonlyusedantifungalthatinhibitsHedgehogpathwayactivityandcancergrowth.CancerCell,2010.17(4):p.388-99.Chong,C.R.,etal.,Inhibitionofangiogenesisbytheantifungaldrugitraconazole.ACSChemBiol,2007.2(4):p.263-70.PaceJR,etal.RepurposingtheClinicallyEfficaciousAntifungalAgentItraconazoleasanAnticancerChemotherapeutic.JMedChem.2016Apr28;59(8):3635-49.AlbulescuL,etal.Uncoveringoxysterol-bindingprotein(OSBP)asatargetoftheanti-enteroviralcompoundTTP-8307.AntiviralRes.2017;140:37-44.McePdfHeight1/1 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>