肠道真菌和病毒在酒精相关性肝病的作用-国际临床研究杂志

【关键词】酒精相关性肝病（ALD）；肠道真菌；肠道病毒；肠道微生【Abstract】Alcohol-relatedliverdiseaseisaffectingpeople'squalityoflife.Therefore,thestudyofalcohol-relatedliverdiseaseneedspathogenesisandprognosisarenotclear.Intestinalmicroecologyisaresearchhotspotinremicroecologyplaysanimportantroleintheoccurrenceanddevelopmentofalcohol-relatedliverdisease.Aofstudieshavefoundthatintestinalflora,dominatedbybacteria,isrelatedtothepathogenesisofalcohodisease.LessresearcvirusesandhumanoranimalhealthanddiseasesathomeandabroadanddistributionofintestinalfungiandenteroviruseswerandenterovirusesandALD,soastofindnewtherapeutictargetsandprovidenewALD.【Keywords】Alcohol-relatedliverdisease(ALD);Intestinalfungi;Enterovirus;Gutmicrobes;Enteroh与酒精相关的肝癌患者死亡约占肝癌总死亡人数的肠-肝轴作为非真实存在的代谢器官，通过物质代进一步检查了两种丰富的真菌，酿酒酵母和白色念珠床对照试验中，收集酒精使用障碍者（alcoholuse伊萨酵母属（Issatchenkia）、白念珠菌属（Candida后其肝功能改善的水平与肠道念珠菌和马拉色菌丰度患者预后的治疗靶点，需要进一步研究来验证这一观酿酒酵母抗体（Anti-SaccharomycesCerevisiaeAnti-后，后者血清IL-1β水平显著降低，进一步分析提示度增加，细小病毒科（Parvoviridae）和疱疹病毒科部分病毒与ALD进展相关，葡萄球菌噬菌体肠道病毒可能通过与肠道菌群的多重相互作用来说明噬菌体可以调节粘膜免疫来影响宿主健康及疾病常规使用改善肝功能药物是目前常规治疗手段。对于对于肝硬化失代偿期患者，可利福昔明抗感染治露的小鼠中给予抗真菌药物可以减少肠道真菌的过度epidemiologyofalcohol-associatedcirrhosisandHCC:trends,projectionsandriskfactors[J].NatRevGastroenterolHepatol,2023,20(1):37-contributingtoalco[3]AlbillosA,DeGottardiA,RescignoM.Thegut-liveraxisinliverdisease:PathophysEndotoxemia,andTheirRelatiMicrobiotaCompositioninAlcohoAlcoholClinExpRes,2018,42(12):2313-23microbiotachangesassociatedwithchronicadministrationinmice[J].Gu[7]BajajJS.Alcohol,liveNatRevGastroenterolHepatol,[8]LangS,SchnablB.MMicrobe,2020,28(2):233-MicrobiomeAxisinHealthandDiseasePeayKG,KenfbiodiversityintheEarthmmycobiomeoftheHumanMicrobiomeProjecthealthyfungiofthehumangutmicrobiome:correlationswithdietandbacterialresidents[J].PLoSOne,2013,8(6):interkingdommicrobialcommunitiesintheprimordialInvestigatingColonizationoftheHealthyAdultGastrointestinalTractbyFungi[J].mSphere,2018,3(2FungalMicrobiomeinAlcoholUseDisorder[J].FrontandSystemicImmuneResponsetoFungAlcoholicHepatitis[J].Hepatology,2020,contributetodevelopmentofalcoholiclivamelioratesinflammasome-dependentsteatohepatitisinmice[J]Nature,2016,532(759gutmicrobiotabypolysaccharidesofWolfiporiacocosrevealsthecontributionofthegutfungi-inducedPGEHumanGutViromIndividualSpecific[J].CellHostMicrobe,20527-541e5.[26]GregoryAC,ZablockiO,ZayedAA,etal.TheGDatabaseRevealsAge-DependentPatternsofVirome28(5):724-740e8.Metagenomics,RelationswithHumanDiseases,andTherapeuticApplicatioHerpesvirusesIncreasetheSeverityofHepatitis[J].ofhumanherpesvirustype8alreadchronichepatitisbeforethedevelopmentofcir[31]ChouAL,HuangWW,TsaoSM,etal.Humanhetype8inpatientswithcirrhosis:correlaalcoholism,hepatithrombocytopenia[J].AmJClinPathol,2008,130(2):associatedwithahigherChild-PughscoreandmaypredictpoorprognosesforpatientswithlBacteriophages,CommensalImmunity[J].TrendsMicrobiol,[34]BajajJS,SikaroodiM,ShamsaddiniA,etal.Interactionofbacterialmetagenomeandviromeinpatieandhepaticencepsafetyrequirementsforsustainablephagetherproducts[J].PharmRes,2015,32(7):2173-9.[36]CheroutreH,MadakamutilL.memoryTcellsjoinforcesatthemucosalfronRevImmunol,2004,4(4):290-3intestinalintraepitheliallymphocytBacteriophagesIsLinkedtoAggravatedIntestinalInflammationandColitis[J].CellHostMicrobe25(2):285-299e8.[40]EuropeanAssociationAddressEEE,EuropeanAssociationfortheStudyofTheL.EASLClinicalPracticeGuidelinesforthemanofpatientswithdecompensatedcirrhosis[J].JHepatol,preventscomplicatiowithdecompensatedlivpatientswithrefractorytypeascites][J].ZhonghuaGan[43]FujimotoY,KajiK,Nizincacetateandrifaxliverfibrosisbymaintainingintestinalbboulardii:WhatMakesItTickasSuccessfulProJFungi(Basel),2020,6(2).[45]Kazmierczak-SiedleckaK,RuszkowskiSaccharomycesboulardiiCNCMI-745:MicroorganismUsedasProbioticAgenTreatmentofSelectedDisealleviatesulcerativecolitisrebalanci