Amitriptyline-hydrochloride-Standard-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAmitriptylinehydrochloride(Standard)Cat.No.:HY-B0527ARCASNo.:549-18-8分⼦式:C₂₀H₂₄ClN分⼦量:313.86作⽤靶点:SerotoninTransporter;5-HTReceptor;HistamineReceptor;mAChR;AdrenergicReceptor;SodiumChannel;TrkReceptor作⽤通路:NeuronalSignaling;GPCR/GProtein;

Immunology/Inflammation;MembraneTransporter/Ion

Channel;ProteinTyrosineKinase/RTK储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验DMSO:≥100mg/mL(318.61mM)H2O:≥50mg/mL(159.31mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制备储备液1mM3.1861mL15.9307mL31.8613mL5mM0.6372mL3.1861mL6.3723mL10mM0.3186mL1.5931mL3.1861mLBIOLOGICALACTIVITY⽣物活性Amitriptyline(hydrochloride)(Standard)Amitriptyline(hydrochloride)的分析标准品。本产品⽤于研究及分析应⽤。Amitriptylinehydrochloride⼀种⾎素再摄取转运体(SERT)和去甲肾上腺素再摄取转运体(NET)抑制剂，对⼈的SERT和NET作⽤的Ki值分别为3.45nM和13.3nM。Amitriptylinehydrochloride还与多巴胺再摄取转运体(DAT)结合，其Ki为2.58μM。Amitriptylinehydrochloride也抑制肾上腺素能受体(adrenergicreceptor)、毒蕈碱受体(muscarinicreceptor)、组胺受体(histaminereceptor)、5-羟⾊胺受体(5-HTreceptor)。Amitriptylinehydrochloride⼀种具有强神经营养活性的TrkA和TrkA受体激动剂。1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEAmitriptylinehydrochloride具有抗抑郁作⽤[1][2][3]。IC50&TargetTrkATrkB户使⽤本产品发表的科研⽂献•JMedVirol.2022Nov1.•CellCommunSignal.2023May25;21(1):123.•PLoSNeglTropDis.2019Aug20;13(8):e0007681.Seemorecustomervalidationsonwww.MedChemEMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589