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ConstructiveCaseNumber:ZM120510Customer:Dr.ManuscripttitleGeneralGeneralBriefsummaryofthisAcarotidatheroscleroticratmodelwasestablishedinthecurrentstudytoevaluatewhethercoldexposure(4oC)affectbloodpressure,levelsofserumendothelin-1(ET-1)levels,levelsofserumnitricoxide(NO)andtheincidenceofcerebralinfarction.Theauthorsrevealedcoldexposurecausedincreasesinbloodpressure,inlevelsofET-1andserumNOincarotidatheroscleroticrats.ThechangeinbloodpressureaftercoldexposurecouldbeebyNimodipine,adihydropyridinecalciumchannelblockeroriginallydevelopedforthetreatmentofhighbloodpressure.Dramaticchangesinbloodpressurecausedbytemperaturefluctuationsispossiblyoneofthemajorreasonsleadingtocerebralinfarction.本研究建立了一个颈动脉粥样硬化大鼠模型，评价寒潮（4oC）对血压、内皮素-1(ET-1)含量、一氧化氮（NO）含量和脑梗死的影响。作者发现寒潮导致颈动脉粥样硬化大鼠血压升高，ET-1和NO含量增加。Novelty&clinicalTheprevalenceofhypertensionisincreasedinwinterandcoldtemperaturesmaytriggercardiovascularcomplicationssuchasischemicstroke.Establishmentofcold-inducedcerebralinfarctiononcarotidatheroscleroticratmodelsmayallowscientiststoinvestigatethepossiblefactorsassociatedwiththeoccurrenceofIschemicstrokeincoldweather.Inthecurrentwork,theauthorssuggestthatdramaticchangesinbloodpressurecausedbytemperaturefluctuationsispossiblyoneofthemajorreasonsleadingtocerebralinfarction.TherearefewarticlesinPubMedthatspecificallydiscussthecoldstress-effectoncerebralinfarctionincarotidatherosclerosisanimalmodel.Thusthisreporthasnoveltyinliture.冬季和低温时高血压的患病率增加，可能会心血管并发压剧烈变化可能是导致脑梗死的重要原因之一。PubMed中几 randEnglishThemanuscriptwasnotwritteninMissingTheauthorshouldconsideringdescribingtheriskfactorsassociatedwithcarotidatherosclerosisthatmaycauseischemicstrokeandcerebralinfarction.中和脑梗死的。Themanuscriptlackcorrespondingauthorinformation,fundinginformation,andacknowledgements.Nodatafromnormalratandshamsurgicalgroupswereshowninmanuscript.Theauthorhasmentionedthecharacteristicsofbothgroupsbutnodataregarding eofcoldstressanddrugtreatmentforthosegroups.RewritingIngeneral,themanuscriptwaswritteninstudentthesisformation.Itwillneedtoreorganizeasaconcisemanuscript.Thegenerationofacarotidatheroscleroticratmodelisnotnovel.Therefore,theauthorneedtoyzewhatistheimpactoftheirwork/resultsandthentoemphasizetheimpactoftheirfinding.总的来说，这篇文章是以学生的形式撰写的。需要对其进大鼠模型的产生并不新颖。因此，作者需要分析他们的研究/Separatetable,figandfigurelendsfromthemainSpecificSpecificThemanuscriptdidnotcomewiththetitleorthetitlepageinIffurtherexperimentalevidencescanbeprovided,theauthorcanconsiderproposingatitleas“Dramaticchangesinbloodpressurecausedbytemperaturefluctuationsinducedcerebralinfarctionincarotidatheroscleroticrats”.如果可以提供进一步的实验，作者可以考虑提出一个标题为“Dramaticchangesinbloodpressurecausedbytemperaturefluctuationsinducedcerebralinfarctionincarotidatheroscleroticrats”。&Inthe ,insteadofdescribingacarotidatheroscleroticratmodelwasestablishedtoevaluatewhethercoldexposureaffectbloodpressure,levelsofserumendothelin-1(ET-1)levels,levelsofserumnitricoxide(NO)andtheincidenceofcerebralinfarction,theauthorshouldemphasizethat,basedonusingacarotidatheroscleroticratmodel,identifieddramaticchangesinbloodpressurecausedbytemperaturefluctuationsinducedcerebralinfarctionincarotidatheroscleroticrats(p.s.Thisconclusionstillrequiressomemoreevidencestosupport!)andNimodipinetreatmentwasnotabletopreventcerebralinfarctioninducedbytemperaturefluctuationsinthesecarotidatheroscleroticrats.在中，不要叙述建立一个颈动脉粥样硬化大鼠模型是为了评价寒潮对血压、内皮素-1(ET-1)含量、一氧化氮（NO）含量和脑梗死的影响，作者应该，基于使用一个颈动脉颈动脉粥样硬化大鼠脑梗死（这个结论将需要的来支Ingeneral,theintroductionpartclearlypointoutthepoints.However,theauthorsshouldconsideremphasizingthatrequirementofananimalmodeltodeterminewhytheincidenceofischemicstrokeisincreasedincoldweather.Andthenfollowingbybriefingthepossiblemechanismincludingcoldexposureaffectingbloodpressure,levelsofserumendothelin-1(ET-1)levels,levelsofserumnitricoxide(NO)etc.SinceNimodipinetreatmentwasnotabletopreventcerebralinfarctioninducedbytemperaturefluctuations.Theauthorsmaythinkofmovingthepartof“Nimodipinebackground”todiscussionsection.总的来说，引言部分清楚地了要点。但是，作者应该考虑强调，需要一个动物模型来确定为什么寒冷天气时脑卒中的会增加。然后简述可能的机制，包括寒潮对血压、内皮素1（ET-1）含量、一氧化氮（NO）含量等的影响。此后地平处理MaterialsandItwouldbenecessarytodefinethecomponentof“highfatdiet”.Otherwise,itmayaffectreproducibility.Itwouldbearequirementforauthorstoclearlydescribehowtheymade“ArtificialClimateBox“and/ortocitethereferencetosupporttheestablishmentofthesystem.作者需要清楚地叙述他们如何制造“ArtificialClimateBox”，和/或Theauthorsshouldclearlydescribewhentheystarttomeasurethebloodpressureandthetimepointsformeasurementsinrelativetodailycycleanddrugtreatment；betterwithascheme.Ingeneral,resultsofthestudyhavenotbeenclearlysummarized.Forexample,althoughthetabledidclearlyshowthevalue,theauthorsstillneedtodescribewhattheactualchangesare.Forexample,whatistheincreasedpercentageinbloodpressureaftercoldtreatment?WhatisthedifferenceinthelevelofET-1beforeandaftercoldtreatment?ET-1含量有什么不同？Mostimportantly,inordertoconcludethat“dramaticchangesinbloodpressurecausedbytemperaturefluctuationsispossiblyoneofthemajorreasonsleadingtocerebralinfarction,”theauthorshouldconsidertomeasurebloodpressureatdifferenttimepointinordertoshowdramaticchangecurveinbloodpressurecausedbytemperaturefluctuations.Furthermore,thedramaticchangecurveinbloodpressurecanfurtherbeusedtodeterminewhyNimodipinetreatmentwasnotabletopreventcerebralinfarctioninducedbytemperaturefluctuations.Moreover,theauthorsneedtoconsidersettingdifferentcold-exposureperiodsaswellasdifferenttemperaturedifferenceinordertoshowthatincreasetemperaturefluctuationslargelyinducecerebralinfarction.Table1,howtoexinwhythereisnosignificantdifferencebetweenshamgroupandtheatheroscleroticgroupintermsoftheparameters表1，如何解释为什么假手术组和动脉粥样硬化组在测量的参数方ProvidedataforweightandgenderratioacrossdifferentShamgroupshouldbeincludedforcold-inducedtreatmenttoruleoutthepossibilitythathypertensionalonecauseddeathduetoabrupttemperature压单独造成的可能性。Ingeneral,thediscussionpartwaswrittenasanassay.SomedescriptionshouldbeincorporatedintoResultsection.Ifpossible,theauthorshouldre-writethewholesection.Basically,theDiscussionsectionshouldbeusedtoemphasizethequestionofthefield,andwhattheauthorshavedoneinthecurrentwork.Ingeneral,thefirstparagraphoftheDiscussionsectionshouldpointouttheimportantfindingofthecurrentstudyanditsimpacts.Theauthorshouldtrytocomparetheirfindingswithotherpublished/relatedwork.Iftheauthorsdonotthinkthathypertensionisthekeyinducerofcerebralinfarction,thentheauthorshouldnotusedabigparagraphtodescribewhythebloodpressurewasincreased.Furthermore,ifNimodipinetreatmentwasnotabletopreventcerebralinfarctioninducedbytemperaturefluctuations,theauthorsstillneedprovidemoreexperimentalevidencesandliturestosupporttheideathat“dramaticchangesinbloodpressurecausedbytemperaturefluctuationsinducedcerebralinfarctionincarotidatheroscleroticrats”.Moreover,theauthorswillalsoneedtodiscusstheirfindingandtheclinicalsignificance.论部分应该用于强调该领域的问题，以及作者在本研究中所做的。一般，讨论部分的第一段应该本研究的重要结果及其影响。作者应尽量将他们的结果与其它已经的/相关的研究结果进行比应该用一大段叙述血压为什么会升高。此外，如果地平处理不可能防止温度波动引起的脑梗死，那么作者还需要提供的实验和文献来支持这个观点“dramaticchangesinbloodpressurecausedbytemperaturefluctuationsinducedcerebralinfarctionincarotidatheroscleroticrats”。而且，作者还需要讨论他们的结果及临床意Citationofreference9&10mayleadtoexposetheweaknessofthecurrentstudyasthecurrentstudydidnotyzewhetheraltioninbloodviscosityandthenumberofetandredcellwhichthenleadto参考文献9和10的可能会导致本研究的弱点，因为本研究Theauthorshouldconsidercitingacouplereferencesdescribingtheriskfactorsassociatedwithcarotidatherosclerosisthatmaycauseischemicstrokeandcerebralinfarction.作者应该考虑，几个叙述与颈动脉粥样硬化有关的可能导致缺血性卒中和脑梗死的的参考文献。Legendsareneededtobrieflydescribetheexperimentalcondition(e.g.treatmentperiod?)andyticmethodsused.Suggestplottingtable1,3,4asTherewasnopictureinFigureTheresolutionofH&EimagesinFigure2needtobeThedatawasnotsu