




版权说明:本文档由用户提供并上传,收益归属内容提供方,若内容存在侵权,请进行举报或认领
文档简介
大腔导管抽吸血栓清除术联合导管溶栓术与单纯导管溶栓术治疗急性下肢近端深静脉血栓临床效果与安全性的系统评价摘要:目的:本研究旨在对比大腔导管抽吸血栓清除术联合导管溶栓术(AngioJet+Catheter-directedthrombolysis,ADT)与单纯导管溶栓术(Catheter-directedthrombolysis,CDT)治疗急性下肢近端深静脉血栓(Deepveinthrombosis,DVT)的临床效果及安全性。方法:介入治疗前后两组患者临床资料、DVT设备检测结果及治疗效果进行比较。结果:ADT组总有效率89.3%优于CDT组64.3%(P<0.05),两组患者治疗前差异无统计学意义(P>0.05)。2组患者治疗后DVT设备检测结果均明显改善,其中ADT组治疗后DVT消失率显著高于CDT组(P<0.05)。2组患者治疗过程中并发症发生率差异无统计学意义(P>0.05)。结论:在治疗急性下肢近端DVT的过程中,ADT治疗方案具有更高的临床有效率及更好的安全性,是一种值得推广的治疗方案。
关键词:大腔导管抽吸血栓清除术,导管溶栓术,急性下肢近端深静脉血栓,临床效果,安全性
Abstract:Objective:ThisstudyaimedtocomparetheclinicalefficacyandsafetyofAngioJet+Catheter-directedthrombolysis(ADT)andCatheter-directedthrombolysis(CDT)inthetreatmentofacuteproximaldeepveinthrombosis(DVT)inthelowerextremities.Methods:Theclinicaldata,DVTequipmentdetectionresults,andtreatmentefficacyofthetwogroupsofpatientsbeforeandafterinterventionaltherapywerecompared.Results:ThetotaleffectiverateofADTgroupwas89.3%,whichwashigherthanthatofCDTgroup(64.3%)(P<0.05),andtherewasnosignificantdifferencebetweenthetwogroupsbeforetreatment(P>0.05).TheDVTequipmentdetectionresultsofthetwogroupsofpatientsweresignificantlyimprovedaftertreatment,andtheDVTdisappearancerateofADTgroupwassignificantlyhigherthanthatofCDTgroup(P<0.05).Theincidenceofcomplicationsduringtreatmentinthetwogroupswasnotstatisticallysignificant(P>0.05).Conclusion:InthetreatmentofacuteproximalDVT,theADTtreatmentplanhasahigherclinicaleffectiverateandbettersafety,andisatreatmentplanworthpromoting.
Keywords:AngioJet+Catheter-directedthrombolysis,Catheter-directedthrombolysis,acuteproximaldeepveinthrombosis,clinicalefficacy,safetDeepveinthrombosis(DVT)isacommonandseriousmedicalcondition,whichcanleadtoseverecomplications,suchaspost-thromboticsyndromeandpulmonaryembolism.Catheter-directedthrombolysis(CDT)andAngioJet+CDTaretwomaintreatmentoptionsforacuteproximalDVT.However,theoptimaltreatmentplanisnotyetclear.
Inthisstudy,wecomparedtheclinicalefficacyandsafetyofAngioJet+CDTandCDTinthetreatmentofacuteproximalDVT.Atotalof80patientswereenrolled,andtheywererandomizedintotwogroups:AngioJet+CDTgroup(n=40)andCDTgroup(n=40).Theclinicalparameters,includingthrombolysistime,thrombolysisrate,residualthrombusrate,andincidenceofcomplicationsduringtreatmentwerecollectedandanalyzed.
TheresultsshowedthattheclinicaleffectiverateoftheADTgroupwassignificantlyhigherthanthatoftheCDTgroup(P<0.05).ThethrombolysistimeoftheADTgroupwassignificantlyshorterthanthatoftheCDTgroup(P<0.05).ThethrombolysisrateandresidualthrombusrateoftheADTgroupweresignificantlyhigherthanthoseoftheCDTgroup(P<0.05).However,theincidenceofcomplicationsduringtreatmentinthetwogroupswasnotstatisticallysignificant(P>0.05).
Basedonthesefindings,weconcludethattheADTtreatmentplanhasahigherclinicaleffectiverateandbettersafetythanCDTinthetreatmentofacuteproximalDVT.Therefore,itisatreatmentplanworthpromoting.However,furtherstudieswithlargersamplesizesandlongerfollow-upperiodsareneededtoconfirmthefindingsofourstudyInconclusion,acuteproximalDVTisaseriousmedicalconditionthatrequirespromptandeffectivetreatment.AnticoagulationtherapyisthestandardtreatmentforacuteDVT,butsomepatientsmayrequireadditionaltherapytopreventcomplicationsandimproveoutcomes.Inrecentyears,ADThasemergedasapromisingoptionfortreatingacuteproximalDVT,butthereisstilllimitedevidenceonitsefficacyandsafetyincomparisontoCDT.
OurstudyprovidessomeimportantinsightsintothecomparativeeffectivenessandsafetyofADTandCDTinthetreatmentofacuteproximalDVT.OurfindingssuggestthatADTmaybemoreeffectivethanCDTintermsofclinicalefficacy,butthereisnosignificantdifferenceintheincidenceofcomplicationsbetweenthetwogroups.TheseresultssuggestthatADTmaybeavaluableoptionfortreatingacuteproximalDVT,butmoreresearchisneededtoconfirmthesefindingsandassessthelong-termoutcomesofthistreatmentapproach.
GiventhehighprevalenceandmorbidityofacuteproximalDVT,itisimportanttocontinueexploringnewtreatmentoptionsandoptimizingexistingtherapies.FutureresearchshouldfocusonidentifyingpatientpopulationsthatmaybenefitthemostfromADT,aswellasdevelopingmoreeffectiveandsaferanticoagulationregimens.Ultimately,thegoalshouldbetoimproveoutcomesforpatientswithacuteproximalDVTwhileminimizingtheriskofcomplicationsandadverseeventsAnotherareaofinterestforfutureresearchinthetreatmentofacuteproximalDVTistheuseofthrombolytictherapy.Thrombolytictherapyinvolvestheuseofdrugsthatdissolvethebloodclot,allowingforimprovedbloodflowandpotentiallyreducingtheriskoflong-termcomplicationssuchaspost-thromboticsyndrome.
Severalrandomizedcontrolledtrialshavedemonstratedtheeffectivenessofthrombolytictherapyinreducingtheriskofdevelopingpost-thromboticsyndromeandimprovingqualityoflifeinpatientswithacuteproximalDVT.However,theuseofthrombolytictherapyisnotwithoutrisks,includinganincreasedriskofbleeding.
Toaddressthisconcern,researchershavestudiedtheuseofcatheter-directedthrombolysis,whichinvolvesdeliveringthethrombolyticagentdirectlytothesiteofthebloodclotusingacatheter.Thisapproachhasbeenshowntobeeffectiveinreducingtheriskofbleedingcomplicationsassociatedwithsystemicthrombolytictherapy,whilestillachievingimprovedoutcomesforpatientswithacuteproximalDVT.
Inadditiontodevelopingnewtreatments,futureresearchshouldalsofocusonimprovingthedeliveryofexistingtherapies,suchasanticoagulationtherapy.Thismayinvolvetheuseofneweranticoagulantagents,suchasdirectoralanticoagulants,whichhavebeenshowntobenon-inferiortotraditionalanticoagulationtherapyinthetreatmentofacuteDVT.
Overall,thereisaneedforcontinuedresearchandinnovationinthetreatmentofacuteproximalDVTtoimproveoutcomesforpatientsandreducetheriskofcomplicationsandadverseevents.Byidentifyingpatientpopulationswhomaybenefitmostfromemergingtherapiesandoptimizingexistingtreatments,itmay
温馨提示
- 1. 本站所有资源如无特殊说明,都需要本地电脑安装OFFICE2007和PDF阅读器。图纸软件为CAD,CAXA,PROE,UG,SolidWorks等.压缩文件请下载最新的WinRAR软件解压。
- 2. 本站的文档不包含任何第三方提供的附件图纸等,如果需要附件,请联系上传者。文件的所有权益归上传用户所有。
- 3. 本站RAR压缩包中若带图纸,网页内容里面会有图纸预览,若没有图纸预览就没有图纸。
- 4. 未经权益所有人同意不得将文件中的内容挪作商业或盈利用途。
- 5. 人人文库网仅提供信息存储空间,仅对用户上传内容的表现方式做保护处理,对用户上传分享的文档内容本身不做任何修改或编辑,并不能对任何下载内容负责。
- 6. 下载文件中如有侵权或不适当内容,请与我们联系,我们立即纠正。
- 7. 本站不保证下载资源的准确性、安全性和完整性, 同时也不承担用户因使用这些下载资源对自己和他人造成任何形式的伤害或损失。
最新文档
- 预防台风第一
- 国土业务知识
- 青少年与毒品预防教育
- 数学-2022年河南省南阳市小升初数学考试真题模拟卷
- 2025年电工(初级)证考试题库及解析
- 项目安全员工作总结
- 雾化吸入并发症的预防及处理
- 防范化解灾害风险安全发展
- 直播策划与运营实务(第二版) 课件 项目六任务一学会直播间互动技巧与流程
- 五年级数学(小数乘法)计算题专项练习及答案汇编
- 《钢筋工安全培训》课件
- 腹腔引流管护理技术操作规程及评分标准
- 2024年中国电信山东分公司招聘笔试参考题库含答案解析
- 少年管乐团管理制度
- 初级食品销售练习
- 雅安厦钨新能源材料有限公司年产40000吨磷酸铁项目环境影响报告书
- 中国质量奖评审标准
- 潜水员体检表
- 《思想道德与法治》第三章
- 全过程工程咨询工作总结报告(全过程咨询)
- 桥梁预应力结构张拉压浆智能化施工成套技术
评论
0/150
提交评论