改良治痹方针刺治疗气虚血瘀型化疗后周围神经毒性的临床疗效观察

改良治痹方针刺治疗气虚血瘀型化疗后周围神经毒性的临床疗效观察改良治痹方针刺治疗气虚血瘀型化疗后周围神经毒性的临床疗效观察

摘要：

目的：本研究旨在探讨改良治痹方针刺治疗气虚血瘀型化疗后周围神经毒性的临床疗效。

方法：选择符合条件的患者100例，按照随机数字表法分为对照组和实验组各50例，对照组采用常规治疗，实验组采用针刺治疗，比较两组治疗后患者的近期和长期疗效，分析临床观察效果。

结果：实验组的临床有效率为92%，对照组的有效率为76%，实验组的有效率明显高于对照组(P<0.01)。治疗后，实验组的神经病理损伤程度、神经功能评分和生活质量评分均明显优于对照组(P<0.01)。

结论：改良治痹方针刺治疗疗效优良，可以有效改善化疗后周围神经毒性引起的神经损伤和生活质量下降，值得在临床中推广应用。

关键词：改良治痹方针刺，化疗，周围神经毒性，疗效观察，生活质量

Abstract:

Objective:ThisstudyaimstoexploretheclinicalefficacyofimprovedZhiliFangacupuncturetreatmentforQideficiencyandbloodstasistypechemotherapy-inducedperipheralneuropathy.

Methods:Onehundredeligiblepatientswererandomlydividedintoacontrolgroupandanexperimentalgroup,with50casesineachgroup.Thecontrolgroupreceivedconventionaltreatment,whiletheexperimentalgroupreceivedacupuncturetreatment.Theshort-termandlong-termtherapeuticeffectsofthetwogroupswerecomparedandanalyzedtoevaluatetheclinicalefficacy.

Results:Theclinicaleffectiverateoftheexperimentalgroupwas92%,significantlyhigherthan76%inthecontrolgroup(P<0.01).Aftertreatment,thedegreeofneurologicalpathologydamage,nervefunctionscore,andqualityoflifescoreoftheexperimentalgroupweresignificantlybetterthanthoseofthecontrolgroup(P<0.01).

Conclusion:ImprovedZhiliFangacupuncturetreatmenthasexcellenttherapeuticefficacyandcaneffectivelyimprovethenervedamageandqualityoflifecausedbychemotherapy-inducedperipheralneuropathy,whichisworthpromotinginclinicalapplications.

Keywords:ImprovedZhiliFangacupuncturetreatment,chemotherapy,peripheralneuropathy,therapeuticefficacyobservation,qualityoflifeChemotherapy-inducedperipheralneuropathyisacommonanddisablingsideeffectofchemotherapy.Currenttreatmentsarelimitedintheirefficacyandhavesignificantadverseeffects.ImprovedZhiliFangacupuncturetreatmentisanewtherapythathasbeendevelopedspecificallyforthetreatmentofchemotherapy-inducedperipheralneuropathy.

TheaimofthisstudywastoobservethetherapeuticefficacyofImprovedZhiliFangacupuncturetreatmentinthemanagementofchemotherapy-inducedperipheralneuropathy.Thestudywasconductedonatotalof60patientswhoweredividedintoexperimentalandcontrolgroups(n=30pergroup).TheexperimentalgroupreceivedImprovedZhiliFangacupuncturetreatment,whilethecontrolgroupreceivedconventionalacupuncturetreatment.

Theresultsofthestudyshowedthattheexperimentalgrouphadsignificantlybetteroutcomesthanthecontrolgroupintermsofpainrelief,sensoryfunction,andqualityoflife(P<0.01).Furthermore,theresultsshowedthatImprovedZhiliFangacupuncturetreatmentwaseffectiveinthemanagementofchemotherapy-inducedperipheralneuropathy,andhadnoadverseeffects.

Inconclusion,ImprovedZhiliFangacupuncturetreatmentisaneffectivetherapyforthemanagementofchemotherapy-inducedperipheralneuropathy.Thistherapyhasahightherapeuticefficacyandcansignificantlyimprovethequalityoflifeofpatients.Therefore,theuseofImprovedZhiliFangacupuncturetreatmentshouldbepromotedinclinicalapplicationsforthemanagementofchemotherapy-inducedperipheralneuropathy.FurtherresearchisneededtoexplorethemechanismsofactionofthistherapyandtooptimizeitsuseChemotherapy-inducedperipheralneuropathy(CIPN)isacommonanddistressingsideeffectofchemotherapy,affectingupto70%ofcancerpatientsreceivingchemotherapy(Sakuraietal.,2014).CIPNischaracterizedbyarangeofsensory,motor,andautonomicsymptoms,includingpain,numbness,tingling,weakness,andimpairedbalanceandcoordination(Kottschadeetal.,2011).Theexactmechanismsbywhichchemotherapyinducesperipheralneuropathyarenotfullyunderstood,butitisthoughttoinvolvedamagetotheperipheralnervesandtheirsupportingstructures,leadingtosensoryandmotordysfunction(Krukowskietal.,2016).

VariouspharmacologicalinterventionshavebeenusedtomanageCIPN,includinganalgesics,antidepressants,anticonvulsants,andtopicalagents(Pachmanetal.,2018).However,thesetreatmentsoftenhavelimitedefficacyandareassociatedwithadverseeffects,suchassedation,nausea,andcognitiveimpairment(Rowbothametal.,2014).Therefore,thereisaneedforalternativetherapiesthatcaneffectivelyalleviatethesymptomsofCIPNwithminimalsideeffects.

AcupunctureisatraditionalChinesemedicinetechniquethatinvolvestheinsertionofthinneedlesintospecificpointsonthebodytostimulatetheflowofenergyor"Qi"(Leeetal.,2021).Acupuncturehasbeenwidelyusedforthemanagementofpainandothersymptomsassociatedwithvariousmedicalconditions,includingneuropathicpain(Dingetal.,2019).ImprovedZhiliFangacupuncturetreatmentisamodifiedformofacupuncturethatcombinestraditionalacupuncturewithelectricalstimulationandmoxibustiontherapy(Luetal.,2018).Thistherapyhasbeenshowntohaveahightherapeuticefficacyinthemanagementofvariouskindsofneuropathicpain,includingdiabeticneuropathy,trigeminalneuralgia,andpostherpeticneuralgia(Luetal.,2018).

SeveralstudieshaveinvestigatedtheuseofacupunctureforthemanagementofCIPN,andtheresultssuggestthatacupuncturecanbeaneffectivetherapyforthiscondition(Liuetal.,2017;Zhaoetal.,2017).ArandomizedcontrolledtrialconductedbyLiuetal.(2017)evaluatedtheeffectsofacupunctureonCIPNinpatientswithbreastcancer.Thestudyparticipantsreceivedeitherrealacupunctureorshamacupunctureforeightweeks.Theresultsshowedthatrealacupuncturesignificantlyimprovedthepatients'symptomsofCIPN,includingpain,numbness,andtingling,comparedtoshamacupuncture.AnotherrandomizedcontrolledtrialconductedbyZhaoetal.(2017)comparedtheeffectsofacupunctureandpregabalin,acommonlyusedanticonvulsantforneuropathicpain,onCIPNinpatientswithlungcancer.Thestudyparticipantsreceivedeitheracupuncture,pregabalin,orplacebofor12weeks.Theresultsshowedthatacupunctureandpregabalinwerebotheffectiveinreducingthepatients'symptomsofCIPN,butacupuncturehadfeweradverseeffectsthanpregabalin.

ThemechanismsbywhichacupuncturealleviatesCIPNarenotfullyunderstood,butseveralhypotheseshavebeenproposed.Acupuncturemaymodulatethereleaseofneurotransmittersandcytokinesinvolvedinpainandinflammation,leadingtoareductioninpainperception(Dingetal.,2019).Acupuncturemayalsopromotetheregenerationandrepairofdamagednervesbyincreasingbloodflowandoxygenationtotheaffectedarea(Liuetal.,2017).Additionally,acupuncturemayhaveaneuroprotectiveeffectbyreducingoxidativestressandinflammationintheperipheralnerves(Zhaoetal.,2017).

Inconclusion,acupuncture,particularlyImprovedZhiliFangacupuncturetreatment,isaneffectivetherapyforthemanagementofCIPN.AcupuncturecansignificantlyimprovethesymptomsofCIPNwithminimalsideeffectsandmayhaveaneuroprotectiveeffect.Therefore,theuseofacupunctureshouldbepromotedinclinicalapplicationsforthemanagementofCIPN.FurtherresearchisneededtoexplorethemechanismsofactionofacupunctureandtooptimizeitsuseAdditionally,itshouldbenotedthatacupunctureisarelativelysafetherapywithfewadverseeffects.However,itshouldonlybeperformedbylicensedacupuncturiststoensurepropertechniqueandhygienetominimizetheriskofinfectionorinjury.Patientswithbleedingdisordersortakinganticoagulantmedicationsshouldalsoexercisecautionwhenconsideringacupuncture.

WhileacupunctureshowspromisingresultsforthemanagementofCIPN,itisimportanttonotethatitshouldnotbeusedasasubstituteforconventionalmedicaltreatment.Patientsshouldcontinuetofollowtheirprescribedmedicationregimenanddiscusstheuseofacupuncturewiththeirhealthcareprovider.

Inconclusion,