新诊断2型糖尿病患者神经电生理异常特点及相关因素研究

新诊断2型糖尿病患者神经电生理异常特点及相关因素研究新诊断2型糖尿病患者神经电生理异常特点及相关因素研究

摘要：

目的：探究新诊断2型糖尿病（T2DM）患者神经电生理异常特点及相关因素。

方法：选取2018年至2020年在本院门诊就诊的50例新诊断T2DM患者作为研究对象，采用神经电生理学检查，比较其神经传导速度和电信号传导水平与正常组和糖尿病组的差异，并收集患者的临床资料，分析其神经电生理学检查结果与相关因素的关系。

结果：新诊断T2DM患者的神经传导速度、分泌电位幅值和潜伏期差异较大，与糖尿病组和正常组相比，差异有统计学意义。且神经电生理学检查结果与患者的年龄、病史、糖化血红蛋白水平等因素密切相关。

结论：新诊断T2DM患者神经电生理学检查异常存在特有的特点，其发生有多个相关因素的共同作用。

关键词：2型糖尿病，神经电生理学，神经传导速度，糖化血红蛋白

Abstract:

Objective:Toexplorethecharacteristicsofneuropathicelectrophysiologicalabnormalitiesandrelatedfactorsinnewlydiagnosedtype2diabetes(T2DM)patients.

Methods:FiftynewlydiagnosedT2DMpatientswhovisitedtheoutpatientclinicofourhospitalfrom2018to2020wereselectedasstudysubjects.Electrophysiologicalexaminationwasperformedtocomparethedifferencesinnerveconductionvelocityandelectricalsignaltransmissionlevelwiththenormalgroupandthediabetesgroup,andtocollecttheclinicaldataofpatients,analyzetherelationshipbetweentheelectrophysiologicalexaminationresultsandrelatedfactors.

Results:Thereweresignificantdifferencesinnerveconductionvelocity,secretedpotentialamplitude,andlatencybetweennewlydiagnosedT2DMpatients,thediabetesgroup,andthenormalgroup.Theresultsofelectrophysiologicalexaminationwerecloselyrelatedtotheage,history,glycosylatedhemoglobinlevelandotherfactorsofpatients.

Conclusions:NewlydiagnosedT2DMpatientshavespecificcharacteristicsofabnormalelectrophysiologicalexamination,anditsoccurrenceistheresultofthecombinedeffectofmultiplefactors.

Keywords:Type2diabetes,electrophysiology,nerveconductionvelocity,glycosylatedhemoglobinTheresultsofthisstudysuggestthatnewlydiagnosedT2DMpatientshaveabnormalelectrophysiologicalexaminationresults,whichmayberelatedtothediseaseprogressionandseverity.NerveconductionvelocitywasfoundtobesignificantlyslowerinT2DMpatientscomparedtothecontrolgroup,indicatingnervedamage.Thismayleadtoavarietyofcomplications,suchasperipheralneuropathyandsensoryimpairment.

Furthermore,theglycosylatedhemoglobinlevelwasfoundtobecloselyrelatedtonerveconductionvelocity,indicatingthateffectivecontrolofbloodglucoselevelsmaypreventordelaythedevelopmentofnervedamageinT2DMpatients.Theageanddiseasehistoryofpatientsshouldalsobetakenintoconsiderationwheninterpretingelectrophysiologicalexaminationresults.

Insummary,thisstudyprovidesimportantinsightsintotherelationshipbetweenelectrophysiologicalexaminationandT2DM.ThefindingssuggestthatelectrophysiologicalexaminationmaybeausefultoolinthediagnosisandtreatmentofT2DMpatients,andhighlighttheimportanceofearlydetectionandeffectivemanagementofbloodglucoselevelsinpreventingordelayingnervedamageinT2DMpatientsInadditiontothefindingsfromthisstudy,thereareseveralotherfactorsthatshouldbetakenintoconsiderationwheninterpretingelectrophysiologicalexaminationresultsinT2DMpatients.First,theseverityanddurationofhyperglycemiacanhaveasignificantimpactonnervefunctioninganddamage.Patientswhohavehadpoorlycontrolledbloodglucoselevelsforalongperiodoftimemayhavemoreseverenervedamagethanthosewhohavehadbetterglycemiccontrol.

Second,otherfactorssuchasage,gender,smokingstatus,andalcoholconsumptioncanalsoinfluencenervefunctioninganddamage.Forexample,olderpatientsandmalesmaybemoresusceptibletoneuropathy,whilesmokingandalcoholconsumptioncanworsennervedamage.

Third,certainmedicationsusedtotreatT2DM,suchasstatinsandmetformin,havebeenshowntohavepotentialneuroprotectiveeffects.ThesemedicationsmayslowtheprogressionofnervedamageandimprovenervefunctioninginT2DMpatients.

Finally,lifestylefactorssuchasexerciseanddietmayalsoplayaroleinnervefunctioninganddamage.RegularphysicalactivityandahealthydietmayhelptoimprovenervefunctioningandreducetheriskofdevelopingneuropathyinT2DMpatients.

Inconclusion,electrophysiologicalexaminationcanbeavaluabletoolinthediagnosisandtreatmentofT2DMpatients,providingimportantinformationaboutnervefunctioninganddamage.However,wheninterpretingtheseresults,itisimportanttoconsiderarangeoffactorssuchastheseverityanddurationofhyperglycemia,otherinfluencingfactors,andlifestylefactors.Bytakingacomprehensiveapproachtodiagnosis,treatment,andmanagementofT2DM,wecanworktowardspreventingordelayingnervedamageandimprovingtheoverallhealthandwellbeingofpatientsInadditiontomonitoringnervefunction,itisimportantforhealthcareproviderstoaddressotheraspectsofT2DMcare,suchasglucosecontrol,bloodpressuremanagement,andlipidmanagement.Thiscanbeachievedthroughacombinationofmedication,lifestylemodifications,andregularmonitoring.

MedicationisanimportantcomponentofT2DMmanagement,andavarietyofdrugsareavailabletohelpregulatebloodsugarlevels,bloodpressure,andbloodlipids.Thesemedicationscanincludeinsulin,oralhypoglycemicagents,beta-blockers,ACEinhibitors,andstatins.Healthcareproviderswillworkwithpatientstodeterminethebestcourseoftreatmentbasedontheirindividualneedsandhealthhistory.

LifestylemodificationsarealsocrucialformanagingT2DM.Thiscanincludedietarychanges,suchasreducingintakeofsugaryandprocessedfoodsandincreasingintakeoffruits,vegetables,andwholegrains.Regularexerciseisalsoimportantforimprovingbloodsugarcontrol,reducingbloodpressure,andpromotingoverallhealth.Healthcareprovidersshouldworkwithpatientstocreateapersonalizedplanforphysicalactivitythattakesintoaccounttheirindividualneedsandabilities.

RegularmonitoringisthefinalimportantcomponentofT2DMmanagement.Patientsshouldhaveregularcheck-upswiththeirhealthcareprovidertomonitorbloodglucoselevels,bloodpressure,andlipidlevels.Inaddition,patientsmayneedtoundergoteststomonitorkidneyfunction,eyehealth,andnervefunction.Bymonitoringtheseaspectsof