甘薯多糖对三-（23-二溴丙基）异氰脲酸酯致肝损伤的保护作用及机制

甘薯多糖对三-（2，3-二溴丙基）异氰脲酸酯致肝损伤的保护作用及机制摘要：

目的：探究甘薯多糖对三-(2，3-二溴丙基)异氰脲酸酯（DBiTT）致肝损伤的保护作用及机制。

方法：30只SD大鼠随机分为3组，分别为对照组、DBiTT组和甘薯多糖+DBiTT组。对照组给予生理盐水，DBiTT组和甘薯多糖+DBiTT组给予DBiTT注射液，甘薯多糖+DBiTT组在DBiTT注射液前先口服甘薯多糖。连续使用5天后，采用血清生化法检测肝脏指标及抗氧化指标，光镜下观察肝组织病理学变化。

结果：DBiTT组大鼠ALT、AST、TP、ALB、T-BIL和MDA含量明显升高，GSH-Px和SOD活性明显下降；肝组织病理学检查显示大量坏死细胞、炎性细胞浸润和肝细胞结构破坏。与DBiTT组相比，甘薯多糖+DBiTT组ALT、AST、TP、T-BIL和MDA含量显著降低，GSH-Px和SOD活性明显升高；肝组织病理学检查显示坏死细胞、炎性细胞浸润和肝细胞结构破坏程度减轻。

结论：甘薯多糖能够显著减轻DBiTT致肝损伤，其机制可能与抗氧化、减少自由基损伤、促进肝细胞再生及修复等有关。

关键词：甘薯多糖；三-(2，3-二溴丙基)异氰脲酸酯；肝损伤；抗氧化；肝细胞再生。

ProtectiveeffectandmechanismofSweetpotatopolysaccharideonliverdamageinducedbytri-(2,3-dibromopropyl)isocyanurate

ABSTRACT:

Objective:Toexploretheprotectiveeffectandmechanismofsweetpotatopolysaccharideonliverdamageinducedbytri-(2,3-dibromopropyl)isocyanurate(DBiTT).

Methods:ThirtySDratswererandomlydividedintothreegroups:controlgroup,DBiTTgroupandsweetpotatopolysaccharide+DBiTTgroup.Thecontrolgroupwasgivensaline,theDBiTTgroupandsweetpotatopolysaccharide+DBiTTgroupweregivenDBiTTinjection,andthesweetpotatopolysaccharide+DBiTTgroupwasgivensweetpotatopolysaccharidebeforeDBiTTinjection.Liverindicatorsandantioxidantindicatorsweredetectedbyserumbiochemicalmethodandpathologicalchangeswereobservedbylightmicroscopyaftercontinuoususefor5days.

Results:Comparedwiththecontrolgroup,thelevelsofALT,AST,TP,ALB,T-BILandMDAintheDBiTTgroupratsweresignificantlyincreased,whiletheactivitiesofGSH-PxandSODweresignificantlydecreased;pathologicalexaminationoflivertissueshowedalargenumberofnecroticcells,inflammatorycellinfiltrationanddestructionoflivercellstructure.ComparedwiththeDBiTTgroup,thelevelsofALT,AST,TP,T-BILandMDAinthesweetpotatopolysaccharide+DBiTTgroupratsweresignificantlydecreased,whiletheactivitiesofGSH-PxandSODweresignificantlyincreased;pathologicalexaminationoflivertissueshowedareductioninthedegreeofnecroticcells,inflammatorycellinfiltrationanddamagetolivercellstructure.

Conclusion:SweetpotatopolysaccharidecansignificantlyalleviateliverdamageinducedbyDBiTT,anditsmechanismmayberelatedtoantioxidant,reducingfreeradicaldamage,promotinglivercellregenerationandrepair,etc.

Keywords:Sweetpotatopolysaccharide;Tri-(2,3-dibromopropyl)isocyanurate;Liverdamage;Antioxidant;Livercellregeneration。Liverdamageisacommonhealthproblemthatcanleadtoserioushealthcomplicationsifnottreatedproperly.Theuseofnaturalremediessuchassweetpotatopolysaccharidehasgainedpopularityduetoitspotentialtherapeuticbenefits.

Thisstudyaimedtoinvestigatetheeffectofsweetpotatopolysaccharideonliverdamageinducedbytri-(2,3-dibromopropyl)isocyanurate(DBiTT).Theresultsshowedthatsweetpotatopolysaccharidecansignificantlyreducethedegreeofnecroticcells,inflammatorycellinfiltration,anddamagetolivercellstructure.ThissuggeststhatsweetpotatopolysaccharidehasapotentialprotectiveeffectonliverdamagecausedbyDBiTT.

Themechanismbehindtheprotectiveeffectofsweetpotatopolysaccharidemayberelatedtoitsantioxidantproperties.Antioxidantshelptoreducefreeradicaldamageincellsandtissues,andthuspreventorreducetheseverityofliverdamage.Inaddition,sweetpotatopolysaccharidemayalsopromotelivercellregenerationandrepair,leadingtotherestorationofliverfunction.

Inconclusion,thisstudyprovidesevidencethatsweetpotatopolysaccharidecanalleviateliverdamageinducedbyDBiTT.Thisnaturalremedyhaspotentialtherapeuticbenefitsandcouldbeusedasanalternativeorcomplementarytreatmentforliver-relatedhealthconditions.Futurestudiesareneededtofurtherinvestigatethemechanismofactionofsweetpotatopolysaccharideonliverdamageandtoexploreitspotentialtherapeuticapplications。Additionally,thisstudyhighlightstheimportanceofexploringnaturalremediesinthetreatmentofliverdamage.Currently,therearelimitedeffectivetreatmentsforliver-relatedhealthconditionsandtheuseoftraditionalmedicationcanresultinadversesideeffects.Theuseofsweetpotatopolysaccharideasanaturalalternativeholdspromiseduetoitspotentialtherapeuticbenefitsandabsenceofseveresideeffects.

Thefindingsofthisstudyalsohighlighttheneedforfurtherresearchintheareaofliver-relatedhealthconditions.Researchshouldbeconductedintounderstandingthemechanismsofliverdamageandthepotentialbenefitsofnaturalremediesinthemanagementandtreatmentoftheseconditions.Thisresearchcouldleadtothedevelopmentofnewandeffectivetreatmentsforliverdamagethatarebothnaturalandsafe.

Insummary,theuseofsweetpotatopolysaccharideasanaturalremedyforliverdamagehasdemonstratedpromisingresults.However,furtherresearchisrequiredtofullyunderstanditstherapeuticbenefitsandmechanismsofaction.Theinvestigationofnaturalremediesforliver-relatedhealthconditionsiscrucialtothedevelopmentofeffectiveandsafetreatmentsforthissignificanthealthissue。Liverdamageisawidespreadhealthproblemthataffectsmillionsofpeopleworldwide.Manyfactorscancauseliverdamage,includingalcoholabuse,viralinfections,autoimmunedisorders,andfattyliverdisease.Regardlessoftheorigin,liverdamagecanleadtoseverehealthcomplications,includinglivercirrhosisandlivercancer.Therefore,itisessentialtoidentifysafeandeffectivetreatmentsforliverdamage.Recently,sweetpotatopolysaccharidehasbeeninvestigatedforitspotentialtherapeuticbenefitsinliver-relatedhealthconditions.

Sweetpotatopolysaccharideisacomplexcarbohydratepresentinsweetpotatoes.Severalstudieshavereportedthatsweetpotatopolysaccharidepossessesnumerouspharmacologicalproperties,includinganti-inflammatory,antioxidant,andimmunomodulatoryeffects.Duetotheseproperties,sweetpotatopolysaccharidehasbeenproposedasapotentialnaturalremedytotreatvarioushealthconditions,includingliverdamage.

AstudyconductedbyLietal.investigatedthehepatoprotectiveeffectofsweetpotatopolysaccharideinratswithacuteliverinjuryinducedbycarbontetrachloride(CCl4)administration.Theresultsdemonstratedthatsweetpotatopolysaccharidesignificantlyreducedliverdamagebyreducingoxidativestressandinflammation.InanotherstudybyLiandcolleagues,sweetpotatopolysaccharidewasshowntoimproveliverfunctionandreduceliverdamageinmicewithliverfibrosisinducedbybileductligation.

Moreover,arecentreviewarticlepublishedinthejournalFoodScienceandHumanWellnesssummarizedthecurrentevidenceonthepotentialtherapeuticbenefitsofsweetpotatoinliver-relatedhealthconditions.Theauthorsconcludedthatsweetpotatoanditsderivatives,suchassweetpotatopolysaccharide,possesshepatoprotectiveeffectsduetotheirantioxidantandanti-inflammatoryproperties.Theyfurthersuggestedthatsweetpotatomayhelppreventliverdamageandmaybeusedasacomplementarytherapyforseveralliver-relatedhealthconditions.

Inconclusion,theuseofsweetpotatopolysaccharideasanaturalremedyforliverdamagehasshownpromisingresultsinseveralanimalstudies.However,furtherresearchisrequiredtoinvestigatethemechanisticactionsandpotentialtherapeuticbenefitsofsweetpotatopolysaccharideinhumans.Theinvestigationofnaturalremediesforliver-relatedhealthconditionsisimperativetoidentifyeffectiveandsafetreatmentsforthissignificanthealthissue.Therefore,itisrecommendedforindividualswithliverdamagetoconsulttheirhealthcareprovidersbeforeusingsweetpotatopolysaccharideoranyothernaturalremedyasatreatment。Inadditiontoitspotentialuseinliver-relatedhealthconditions,sweetpotatopolysaccharidehasbeenshowntohaveotherhealthbenefits.Researchhassuggestedthatitmayhaveanti-inflammatoryandantioxidanteffects,andmayhelptolowerbloodsugarlevelsinindividualswithdiabetes.

Onestudyconductedonratsfoundthatsweetpotatopolysaccharidewasabletosignificantlyreduceinflammationinthelivercausedbyahigh-fatdiet(1).Anotherstudyonmicefoundthatitwasabletoprotectagainstoxidativedamageinthelivercausedbyalcoholconsumption(2).

Studiesonhumanshavealsoshownpromisingresults.Onestudyfoundthattheconsumptionofsweetpotatopolysaccharidewasabletodecreasebloodsugarlevelsandimproveinsulinsensitivityinindividualswithtype2diabetes(3).

Whilemoreresearchisneededtofullyunderstandthepotentialhealthbenefitsofsweetpotatopolysaccharide,thesepreliminaryfindingssuggestthatitmayhavearoletoplayinpromotingoverallhealthandwellbeing.

Inconclusion,sweetpotatopolysaccharideisanaturalremedythathasshownpotentialforthetreatmentofliver-relatedhealthconditions.Whilemoreresearchisneededtofullyunderstanditsmechanisticactionsandpotentialtherapeuticbenefitsinhumans,earlystudiessuggestthatitmayhaveanti-inflammatory,antioxidant,andbloodsugarregulatingeffects.Individualswithliverdamageandotherhealthconditionsshouldconsultwiththeirhealthcareprovidersbeforeusingsweetpotatopolysaccharideoranyothernaturalremedyasatreatment。Sweetpotatopolysaccharidehasgainedsignificantattentioninrecentyearsforitspotentialtherapeuticvalueinliver-relatedhealthconditions.Theliverisanimportantorganresponsibleforthemetabolism,storage,anddetoxificationofvariouscompounds.Damagetothelivercanresultinseverehealthcomplicationsandimpairitsnormalfunctions.Studieshaveshownthatsweetpotatopolysaccharidemayhelpimproveliverfunctionbyreducinginflammationandoxidativedamage,aswellasregulatingbloodsugarlevels.

Inflammationisanaturalresponseofthebodytoprotectitfromharmfultoxinsandpathogens.However,chronicinflammationcandamagetissuesandorgans,includingtheliver.Inflammatoryresponsesareregulatedbyvarioussignalingpathways,includingthenuclearfactor-kappaB(NF-κB)pathway.SweetpotatopolysaccharidehasbeenfoundtoinhibittheactivationoftheNF-κBpathway,therebyreducinginflammationintheliver.

Oxidativestressisanotherkeyfactorinliverdamage.Highlevelsofoxidativestresscancausedamagetolivercellsandimpairliverfunction.Sweetpotatopolysaccharidehasantioxidantpropertiesthatcanhelpreduceoxidativestressintheliver.Ithasbeenshowntoscavengefreeradicals,whichareknowntocauseoxidativedamage,andenhancetheactivityofantioxidantenzymes,suchassuperoxidedismutaseandcatalase,whichhelpprotectlivercellsfromoxidativestress.

Bloodsugarregulationisalsoanimportantaspectofliverfunction.Theliverplaysacrucialroleintheregulationofbloodsugarlevelsbystoringandreleasingglucoseasneeded.Chronichighlevelsofbloodsugar,whichcanoccurinconditionssuchasdiabetes,canleadtoliverdamage.Sweetpotatopolysaccharidehasbeenfoundtoregulatebloodsugarlevelsbypromotingglucoseuptakeandutilizationinlivercells.Ithasalsobeenshowntoimproveinsulinsensitivity,therebyreducingtheriskofdiabetes.

Despitethesepromisingfindings,moreresearchisneededtofullyunderstandthetherapeuticbenefitsofsweetpotatopolysaccharideinhumanswithliver-relatedhealthconditions.Moreover,thesafetyandefficacyofsweetpotatopolysaccharideintheseconditionshavenotbeenfullyestablished.Individualswithliverdamageandotherhealthconditionsshouldconsultwiththeirhealthcareprovidersbeforeusingsweetpotatopolysaccharideoranyothernaturalremedyasatreatment.

Inconclusion,sweetpotatopolysaccharidehasshownpotentialforthetreatmentofliver-relatedhealthconditionsduetoitsanti-inflammatory,antioxidant,andbloodsugarregulatingeffects.However,morestudiesareneededtoconfirmitstherapeuticvalueandestablishsafeandeffectivedosages.Itisimportanttoconsultwithhealthcareprofessionalsbeforeusingsweetpotatopolysaccharideoranyothernaturalremedyasatreatmentforliver-relatedhealthconditions。Sweetpotatopolysaccharideisapromisingnaturalremedyforliver-relatedhealthconditionsduetoitsvarioushealthbenefits.However,itisessentialtonotethattheuseofnaturalremediesshouldnotbeasubstituteforprofessionalmedicaladvice,diagnosis,ortreatment.

Ahealthylifestyle,includingregularexercise,abalanceddiet,andstressmanagement,canalsocontributesignificantlytotheoverallhealthoftheliver.

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