1-Deoxymannojirimycin-hydrochloride-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE1-DeoxymannojirimycinhydrochlorideCat.No.:HY-W009783CASNo.:73465-43-7分⼦式:C₆H₁₄ClNO₄分⼦量:199.63作⽤靶点:HIV;InfluenzaVirus作⽤通路:Anti-infection储存⽅式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性数据体外实验DMSO:100mg/mL(500.93mM;Needultrasonic)H2O:100mg/mL(500.93mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM5.0093mL25.0463mL50.0927mL5mM1.0019mL5.0093mL10.0185mL10mM0.5009mL2.5046mL5.0093mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(12.52mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.5mg/mL(12.52mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(12.52mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性1-Deoxymannojirimycinhydrochloride⼀种选择性的I类α1,2-⽢露糖苷酶(classIα1,2-mannosidase)抑制剂，IC50为20μM。1-Deoxymannojirimycinhydrochloride也⼀种N-联糖化(N-linkedglycosylation)抑制剂，可抑制HIV-1毒株，具有抗病毒活性。IC50&TargetIC50:20μM(α1,2-mannosidaseI)[1]N-linkedglycosylation[2]HIV‐1[2]REFERENCES[1].FVallee,etal.StructuralBasisforCatalysisandInhibitionofN-glycanProcessingClassIAlpha1,2-mannosidases.JBiolChem.2000Dec29;275(52):41287-98.[2].JanBalzarini,etal.Thealpha(1,2)-mannosidaseIInhibitor1-deoxymannojirimycinPotentiatestheAntiviralActivityofCarbohydrate-BindingAgentsAgainstWild-TypeandMutantHIV-1StrainsContainingGlycanDeletionsingp120.FEBSLett.2007May15;581(10):2060-4.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.T