SS-208-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemESS-208Cat.No.:HY-126330CASNo.:2245942-72-5分⼦式:C₁₃H₁₁Cl₂N₃O₄分⼦量:344.15作⽤靶点:HDAC作⽤通路:CellCycle/DNADamage;Epigenetics储存⽅式:Powder-20°C3years*该产品在溶液状态不稳定，建议您现⽤现配，即刻使⽤。溶解性数据体外实验DMSO:125mg/mL(363.21mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.9057mL14.5285mL29.0571mL5mM0.5811mL2.9057mL5.8114mL10mM0.2906mL1.4529mL2.9057mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现⽤现配，即刻使⽤.体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(6.04mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(6.04mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoil1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.08mg/mL(6.04mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性SS-208⼀个选择性的HDAC6抑制剂，IC50值为12nM。SS-208具有有效的抗⿊⾊素瘤活性。IC50&TargetHDAC6HDAC8HDAC1HDAC1112nM(IC50)1.23μM(IC50)1.39μM(IC50)5.12μM(IC50)HDAC5HDAC76.91μM(IC50)8.34μM(IC50)体内研究SS-208(25mg/kg,ip)significantlyreducesthetumorgrowthinmelanomamurinemodel[1].AnimalModel:C57BL/6miceinjectedimmunogenicmurineSM1melanomacellssubcutaneously[1].Dosage:25mg/kg.Administration:IPonday4,7,12,15and18.Result:Significantlyreducedthetumorgrowth.REFERENCES[1].ShenS,etal.DiscoveryofaNewIsoxazole-3-hydroxamate-BasedHistoneDeacetylase6InhibitorSS-208withAntitumorActivityinSyngeneicMelanomaMouseModels.JMedChem.2019Sep4.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-379