NAMPT-inhibitor-linker-1-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemENAMPTinhibitor-linker1Cat.No.:HY-112615CASNo.:2241019-57-6分⼦式:C₃₆H₃₇FN₆O₆分⼦量:668.71作⽤靶点:Drug-LinkerConjugatesforADC作⽤通路:Antibody-drugConjugate/ADCRelated储存⽅式:-20°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)溶解性数据体外实验DMSO:37.5mg/mL(56.08mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.4954mL7.4771mL14.9542mL5mM0.2991mL1.4954mL2.9908mL10mM0.1495mL0.7477mL1.4954mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(storedundernitrogen)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性NAMPTinhibitor-linker1为ADC的⼀部分，由⼀种NAMPT的抑制剂作为有效载荷和⼀个连接物组成。ADC-3由⼀个NAMPTinhibitor-linker1和⼀个anti-c-Kit单克隆抗体组成，对表达c-Kit的细胞具有抑制作⽤，⽐如GIST-T1和NCI-H526细胞，IC50值分别为[1]。IC50&TargetTraditionalCytotoxicAgents体外研究ADC-3exihibitspotentactivityagainstc-KitexpressingcelllinessuchasGIST-T1andNCI-H526,withIC50s1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEof[1].体内研究ADC-3(20mg/kg,i.v.for28days)istolerated,andcausestumorstasisinmicebearingGIST-T1cells[1].AnimalModel:Femalescid-beige(SCIDbg)mice[1]Dosage:20mg/kgAdministration:Asingleintravenousinjection(i.v.)for28daysResult:Significantlyinhibitedthegrowthoftumorinmice.REFERENCES[1].KarpovAS,etal.NicotinamidePhosphoribosyltransferaseInhibitorasaNovelPayloadforAntibody-DrugConjugates.ACSMedChemLett.2018Jun28;9(8):838-842.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-