R-S-Ivosidenib-R-S-AG-120-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE(R,S)-IvosidenibCat.No.:HY-18767ACASNo.:2070009-31-1Synonyms:(R,S)-AG-120分⼦式:C₂₈H₂₂ClF₃N₆O₃分⼦量:582.96作⽤靶点:IsocitrateDehydrogenase(IDH)作⽤通路:MetabolicEnzyme/Protease储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:3.33mg/mL(5.71mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.7154mL8.5769mL17.1538mL5mM0.3431mL1.7154mL3.4308mL10mM---------请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥0.33mg/mL(0.57mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性(R,S)-Ivosidenib((R,S)-AG-120)Ivosidenib(AG-120)的对映体，活性较低。户使⽤本产品发表的科研⽂献•CellRep.2022Feb15;38(7):110391.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].Popovici-MullerJ,etal.DiscoveryofAG-120(Ivosidenib):AFirst-in-ClassMutantIDH1InhibitorfortheTreatmentofIDH1MutantCancers.ACSMedChemLett.2018Jan19;9(4):300-305.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax