Rac-PF-06256142-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE(Rac)-PF-06256142Cat.No.:HY-119943ACASNo.:1609580-97-3分⼦式:C₂₁H₁₆N₄O₂分⼦量:356.38作⽤靶点:DopamineReceptor作⽤通路:GPCR/GProtein;NeuronalSignaling储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:25mg/mL(70.15mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.8060mL14.0300mL28.0599mL5mM0.5612mL2.8060mL5.6120mL10mM0.2806mL1.4030mL2.8060mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(7.01mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(7.01mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(7.01mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性(Rac)-PF-06256142PF-06256142(HY-119943)的较弱的对映体。(Rac)-PF-06256142D1受体(D1receptor)的激动剂，其EC50值为107nM。(Rac)-PF-06256142可⽤于精神分裂症和帕⾦森病的研究[1]。IC50&TargetHumanD1Receptor107nM(EC50)REFERENCES[1].DavorenJE,etal.DiscoveryandLeadOptimizationofAtropisomerD1AgonistswithReducedDesensitization.JMedChem.2018Nov15.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955