医学免疫学英语试题

1、Chooseonewhichisthebestanswerineachquestion（401point=40）1.Immunologicalunresponsivenesstoselfantigensiscalled:(A)AToleranceBTolerogenCMemoryDAcquiredimmunity2.ThesignaltransductionmoleculesassociatedwithBCRare(B)ndIgCD79a,bC.IgDandIgM.andITIMs.TcellsareMHC-restrictedintheirabilitytorespondtoantigenb

2、ecause(D)A.allantigenmustbeprocessedandpresentedtoactivatelymphocytes.B.duringaninfection,allcellsinthebodypresentantigenonMHCClassI.C.MHCbindsantigenmorespecificallythanTCRdoes.D.TCRmustrecognizebothantigenandMHCmolecules.4.AnantibodyFabcontains(AB)A.complementaritydeterminingregions.B.HandLchainva

3、riableregions.C.oneantigenbindingregion.D.oneH-Linterchaindisulfidebond.5Positiveselectioninthethymusismediatedby:(A)AThymicepithelialcells.BMacrophages.CDendriticcells.DB-cells.6.Typehypersentivityisoftenreferredtoas:(B)A.ImmediatehypersensitivityB.DelayedhypersensitivityC.Cytotoxichypersensitivity

4、D.Allergichypersensitivity7.Typehypersentivityisoftenreferredtoas:(C)A.ImmediatehypersensitivityB.DelayedhypersensitivityC.CytotoxichypersensitivityD.Allergichypersensitivity8.NaiveBcellexpresses(C)A.IgAaloneandIgGCIgM+IgDandIg9.Tcell-derivedcytokines(D)A.areantigen-specificproductsofTcellactivation

5、B.arestoredintherestingTcellandreleasedonactivationC.areMHC-restrictedintheireffectsD.influencetheclassofantibodiesproducedbyBcell10.Neutrophilsareattractedtoaninfectedareaby(C)IgMB.C1C.C5aD.C811.Complementlysescellsby(C)enzymaticdigestionofthecellmembraneactivationofadenylatecyclaseinsertionofcompl

6、ementproteinsintothecellmembraneinhibitionofelongationfactor212.CD8isamarkerof(C)A.BcellsB.Helper-Tcells13.MHCclassmoleculesarefoundon(B)A.VirtuallyallcellsinthebodyB.Bcells,DCandMC.VirtuallyallnucleatedcellsinthebodyD.Onlyonvirally-infectedcells.14.AlloffollowingcytokinesaresecretedbyTh2cellsexcept

7、(B)A.IL-4B.IFN-C.IL-5D.IL-615.WhichofthefollowingisNOTtrueof+markers?(D)CD4andCD8cellA.ThesearebothsurfaceglycoproteinsexpressedonT-cells.B.TheseservetodistinguishdifferenttypesofT-cells,.,helper,suppressorandcytotoxic,fromeachother.C.Thesearenotfoundassociatedwithimmunoglobulins.D.Bothofthemarkersa

8、representonALLT-cells.CellsbearingMHCclassIpluspeptidearetargetsforspecific:(B)Th1cells.DTh2cells.17.Dendriticcellsarecharacterizedby:(D)AthepresenceofmajorbasicproteinBexpressionofCD3CexpressionofIgMmoleculesDtheirinterfacebetweentheinnateandadaptiveimmunesystem18.Whichofthefollowinguniquelydisting

9、uishestheT-cellreceptor(TCR)fromanantibody?(A)A.TheTCRcanbindanantigenfragmentonlyinatrimolecularcomplexwitheithertheclassIorclassIIsurfaceproteinsofthemajorhistocompatibilitycomplexB.TheTCRcanfunctionasacellsurfaceantigenreceptorC.TheTCRiscomposedoftwodifferenttypesofpolypeptidechainsD.TheTCRiscapa

10、bleofparticipatinginacytotoxicreaction.Acriticalpropertyofanantigenis(A)A.ItsabilitytostimulateanimmuneresponseB.auniquetopologicalfeaturecalledanparatopeofbacteriaoccursthroughcoatingbacteriajustwith:(A)AC3bBC8CMembraneattackcomplexDIgM21.ThefollowingischaracteristicofB-butnotT-cells:(D)Surfaceimmu

11、noglobulin.22Whichofthefollowingmoleculesisexpressedonthesurfaceofmature+CD4Tcells?(C)A.BcellreceptorB.CD1d23Thethymusisthesiteofinitialdifferentiationfor（D）A.BcellsB.ErythrocytesC.HematopieticstemcellsD.Tcells24.Themembraneattackcomplexconsistsof:(C)AOHBC3b3b,BbCC5b,6,7,8,9DProperdin25.Typehypersen

12、tivityisoftenreferredtoas:(A)A.ImmediatehypersensitivityB.DelayedhypersensitivityC.CytotoxichypersensitivityD.Immunecomplexhypersensitivity26.Typehypersentivityisoftenreferredtoas:(D)A.ImmediatehypersensitivityB.DelayedhypersensitivityC.CytotoxichypersensitivityD.Immunecomplexhypersensitivity27.Thet

13、ypehypersentivityismediatedby:(D)A.IgAB.IgDC.IgGD.IgEThecytokinewhichismostinvolvedintheclassswitchtoIgEproductionis:(D)betaWhichtypehypersensitivityisrelatedtothemechanismofacuteArthusreaction:(C)A.TypehypersentivityB.TypehypersentivityC.TypehypersentivityD.Typehypersentivity30.T-cellCD40Lprovidesa

14、costimulatorysignaltoB-cellsbyligating:(A)ACD40BMHCclassIICCD28DCD1931.Whichimmunoglobulincanbetransportedthroughtheplacenta?(A)A.IgGB.IgMC.SecretoryIgAD.IgE32.Whichimmunoglobulinisthemostoneintheblood?(A)A.IgGB.IgMC.SecretoryIgAD.IgE33.Whichimmunoglobulincanmediatetheimmediatehypersensitivity?(D)A.

15、IgGB.IgMC.SecretoryIgAD.IgEMoleculesdirectlyinvolvedinNKcellmediatedkillinginclude:(B)AnitricoxideBgranzymeCcomplementDIFN-35.Immunecomplexesconsistof(C)A.antibodypluscomplementB.basophilpluscomplementC.antigenplusantibodyD.antigenpluscomplementThemaincostimulatorysignalforactivationofrestingT-cells

16、isprovidedbyligationof:(A)ACD28BSurfaceIgCLFA-1DVLA-4TheT-cellreceptorantigenrecognitionsignalistransducedby:(E)ATheTCRalphachain.BTheTCRbetachain.DCD2.ECD3.38.TheT-cellligandbindingB7onaprofessionalantigen-presentingcellis:AACD28BCD2CLFA-1DICAM-139.Secondaryantibodyresponsesarebetterbecause:(C)They

17、providedefenseagainstunrelatedantigensTheantibodycanbemadebybothTandBcellsTheyarestrongerandfasterTheydonotrequireT-cellhelpWhichcelltypeproducesantibodies?:(D)AMacrophagesBT-lymphocytesCDPlasmacellsNKII.Indicatewhethereachofthefollowingstatementsistrueorfalse.（102points=20）Ahaptencanstimulateantibo

18、dyformationbutcannotcombinewithantibodymolecules.(F)Boostershotsarerequiredbecauserepeatedexposuretoanantigenbuildsastrongerimmuneresponse.(T)3.TheIg/IgheterodimerandCD3serveanalogousfunctionB-cellreceptorandT-cellreceptor,respectively.(T)4.Antigen-presentingcellsexpressbothclassIandclasssintheIIMHC

19、moleculesontheirmembranes.(T)BabiescanacquireIgE-mediatedallergiesbypassivetransferofmaternalantibody.(F)6.BothCTLsandNKcellsreleaseperforinafterinteractingwithtargetcells.(T)7.Targetcelllysisanddestructioncanbeachievedbyperforinreleasedfromantigen-specificcytotoxicT-cells(T)Theimmuneresponseismedia

20、tedviathehumoraland/orcellulararmsoftheimmunesystem(T)ImmediatetypehypersensitivityismediatedbyIgM.(F)10.Allcytokine-bindingreceptorscintaintwoorthreesubunits.(T)Answerthefollowingquestionsinbrief（104points=40）NamethethreetypesofprofessionalAPCs,andgiveoneexampleofnonprofessionalAPCs.BMDCendothelialcell2.Summarizethefourmajorfunctionsofcomplementsystemlysisofcells,bacteriaandvirusesopsonizationtoenhancephagocytosisclearanceofimmunecomplexesstimulationofinflammationListtheclassicalClassIandClassIIgenelo