UNC2250-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEUNC2250Cat. No.: HY-15797CAS No.: 1493694-70-4分式: CHNO分量: 440.58作靶点: TAM Receptor作通路: Protein Tyrosine Kinase/RTK储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 46 mg/mL (104.41 mM)* means

2、soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.2697 mL 11.3487 mL 22.6974 mL5 mM 0.4539 mL 2.2697 mL 4.5395 mL10 mM 0.2270 mL 1.1349 mL 2.2697 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 UNC2250种有效选择性的 Mer 抑制剂，IC50为 1.7 nM，相关的激酶 Axl 和 Ty

3、ro3 选择性 160 倍和60 倍。IC50 & Target IC50: 1.7 nM (Mer) 1体外研究UNC2250 (5-500 nM; 1 hour) inhibits Mer phosphorylation in 697 B-ALL cells with an IC50 value of 9.8 nM1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE1.UNC2250 efficiently inhibits ligand-dependent phosphorylation of a chimeric protein consi

4、sting of theextracellular and transmembrane domains of the epidermal growth factor (EGF) receptor and the intracellulartyrosine kinase domain of Mer 1.UNC2250 incubation inhibits colony formation in soft agar cultures of the BT-12 rhabdoid tumor and theColo699 NSCLC cell lines 1 .Western Blot Analys

5、is 1Cell Line: 697 B-ALL cellsConcentration: 5, 10, 20, 50, 100, 250, 500 nMIncubation Time: 1 hourResult: Inhibits Mer phosphorylation in 697 B-ALL cells with an IC50 value of 9.8 nM. Theranostics. 2018 Jul 30;8(15):4262-4278.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Zha

6、ng, W., et al., Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines asnew Mer kinase inhibitors. J Med Chem, 2013. 56(23): p. 9683-92.2. /patents/WO2013177168A1McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-82