Apigenin-7-glucuronide-Apigenin-7-O-glucuronide-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEApigenin-7-glucuronideCat. No.: HY-N1454CAS No.: 29741-09-1Synonyms: Apigenin 7-O-glucuronide分式: CHO分量: 446.36作靶点: MMP作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验

2、DMSO : 65 mg/mL (145.62 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.2403 mL 11.2017 mL 22.4034 mL5 mM 0.4481 mL 2.2403 mL 4.4807 mL10 mM 0.2240 mL 1.1202 mL 2.2403 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，

3、体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.17 mg/mL (4.86 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.17 mg/mL (4.86 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn o

4、il1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.17 mg/mL (4.86 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Apigenin-7-glucuronide 能够抑制质属蛋酶 (MMP) 的活性，其对 MMP-3，MMP-8，MMP-9，MMP-13的IC50 值分别为 12.87，22.39，17.52，0.27 M。IC50 & Target MMP-3 MMP-8 MMP-9 MMP1312.87 M (IC50) 22.39 M (IC50) 17.52

5、M (IC50) 0.27 M (IC50)体外研究 Apigenin-7-Oglucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39,17.52, 0.27 M for MMP-3, MMP-8, MMP-9, MMP-13, respectively 1. Scutellarin A also inhibits the migratedcapacity of ACHN and 786-O cells in a dose-dependent manner.

6、It is also revealed that after treatment withScutellarin A (30, 60, and 90 M) for 24 h, the apoptosis rates in ACHN and 786-O cells are remarkablyenhanced dose-dependently when compared to the control groups 2.REFERENCES1. Crasc L, et al. Correlating In Vitro Target-Oriented Screening and Docking: I

7、nhibition of Matrix Metalloproteinases Activities byFlavonoids. Planta Med. 2017 Jul;83(11):901-911.2. Deng W, et al. Scutellarin inhibits human renal cancer cell proliferation and migration via upregulation of PTEN. Biomed Pharmacother.2018 Nov;107:1505-1513.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use