2-Chloropyridin-4-yl-methanamine-hydrochloride-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE(2-Chloropyridin-4-yl)methanamine hydrochlorideCat. No.: HY-101771ACAS No.: 916210-98-5分式: CHClN分量: 179.05作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 H2O : 50 mg/mL (279.

2、25 mM)DMSO : 33 mg/mL (184.31 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 5.5850 mL 27.9252 mL 55.8503 mL5 mM 1.1170 mL 5.5850 mL 11.1701 mL10 mM 0.5585 mL 2.7925 mL 5.5850 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 (2-Chlor

3、opyridin-4-yl)methanamine hydrochloride是选择性的 LOXL2 抑制剂，IC50 值为126 nM。IC50 & Target IC50: 126 nM (LOXL2) 1体外研究(2-Chloropyridin-4-yl)methanamine hydrochloride is shown to be selective for LOXL2 over LOX and three1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEother amine oxidases (MAO-A, MAO-B and SS

4、AO). In the human whole blood LOXL2 assay, (2-Chloropyridin-4-yl)methanamine hydrochloride has an IC50 of 1.45 M compared to 126 nM in the absenceof blood proteins. (2-Chloropyridin-4-yl)methanamine hydrochloride shows a 31-fold selectivity forLOXL2+BSA (IC50=190 nM) over LOX+BSA (IC50=5.91 M). Agai

5、nst a panel of non-LTQ-containing AOenzymes (MAO-A, MAO-B and SSAO), LOXL2-IN-1 is found to be inactive at 30 M. (2-Chloropyridin-4-yl)methanamine hydrochloride is profiled for the inhibition of three different CYP enzymes (CYPs 3A4, 2C9and 2D6) and in each case the IC50 is more than 30 M 1.REFERENC

6、ES1. Hutchinson JH, et al. Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 overLOX. ACS Med Chem Lett. 2017 Mar 1;8(4):423-427.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820