AGN-194310-VTP-194310-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAGN 194310Cat. No.: HY-16681CAS No.: 229961-45-9Synonyms: VTP-194310分式: CHOS分量: 424.55作靶点: RAR/RXR作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 50 mg/mL (117

2、.77 mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.89 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.89 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 AGN 194310(VTP-194310)是RAR激动剂，对RAR/的

3、Kd分别为3/2/5 nM。户使本产品发表的科研献 Biol Open. 2019 Jun 17;8(6). pii: bio044974.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Johnson AT, et al. Synthesis and biological activity of high-affinity retinoic acid receptor antagonists. Bioorg Med Chem. 1999Jul;7(7):1321-38.2. Hammond LA, e

4、t al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer.2001 Aug 3;85(3):453-62.3. Austenaa LM, et al. Vitamin A status significantly alters nuclear factor-kappaB activity assessed by in vivo imaging. FASEB J. 2004Aug;18(11):1255-7.4. Walkley CR, et al. Retinoic acid receptor antagonism in vivo expands the numbers of precursor cells during granulopoiesis. Leukemia.2002 Sep;16(9):1763-72.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589559