McMMAF-Maleimidocaproyl-monomethylauristatin-F-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMcMMAFCat. No.: HY-15578CAS No.: 863971-19-1Synonyms: Maleimidocaproyl monomethylauristatin F分式: CHNO分量: 925.16作靶点: Microtubule/Tubulin; Drug-Linker Conjugates for ADC作通路: Cell Cycle/DNA Damage; Cytoskeleton; Antibody-drugConjug

2、ate/ADC Related储存式: -20C, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (stored undernitrogen)溶解性数据体外实验 DMSO : 100 mg/mL (108.09 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.0809 mL 5.4045 mL 10.8089 mL5 mM 0.2162 mL 1.0809 mL 2.

3、1618 mL10 mM 0.1081 mL 0.5404 mL 1.0809 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 5 mg/mL (5.40 mM);

4、 Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 5 mg/mL (5.40 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Mc-MMAF由效微管抑制剂Monomethyl auristatin F (MMAF) 与保护 团maleimidocaproyl偶联成。MMAF(甲 澳瑞他汀F)为抗微管蛋化合物，能通过阻断微管聚合抑制细胞分裂，较MMAE毒性低，可于抗体偶联药物（ADC）。户使

5、本产品发表的科研献 Patent. US10087260B2. Patent. US20160304621A1.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Polson AG, et al. Antibody-drug conjugates for the treatment of non-Hodgkins lymphoma: target and linker-drug selection. Cancer Res.2009 Mar 15;69(6):2358-2364.2. Jianmin Fang, et al. Anti-her2 antibody and conjugate thereof. US 20160304621 A1.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;