Polygalacic-acid-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPolygalacic acidCat. No.: HY-N0801CAS No.: 22338-71-2分式: CHO分量: 504.7作靶点: MMP; AChE作通路: Metabolic Enzyme/Protease; Neuronal Signaling储存式: Please store the product under the recommended conditions inthe COA.BIOLOGICAL ACTIVITY物活性

2、 Polygalacic acid 果枝花皂苷元 G 种三萜，是从远志 Polygala tenuifolia Willd 根中分离出来的。Polygalacic acid 抑制 MMP 表达。 Polygalacic acid 在关节炎 (OA) 治疗中具有治疗潜。Polygalacic acid对认知障碍有显 的神经保护作，PA 通过抑制酰胆碱酯酶 (AChE) 活性，增加胆碱酰转移酶(ChAT) 活性，提海马和额质中的酰胆碱 (Ach) 平来提胆碱能系统反应性。体外研究Polygalacic acid (0-100 M; 24 hours) significantly decreases

3、 the mRNAexpressions of MMP-3, MMP-9,MMP-13, and COX-2, which are significantly increased by IL-1, in a dose-dependent manner 1.Polygalacicacid (0-100 M; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnkinduced by IL-1, phosphor-p65 is not reduced by polygalacic acid

4、1.RT-PCR 1Cell Line: Chondrocyte cellsConcentration: 50 M; 100 MIncubation Time: 24 hoursResult: Suppressed IL-1-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression.Western Blot Analysis 1Cell Line: Chondrocyte cellsConcentration: 50 M; 100 M1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEIncubati

5、on Time: 6 hoursResult: Inhibited the IL-1-induced activation of the MAPK pathway in chondrocytes.REFERENCES1. Xu K, et al. Polygalacic acid inhibits MMPs expression and osteoarthritis via Wnt/-catenin and MAPK signal pathways suppression. IntImmunopharmacol. 2018 Oct;63:246-252.2. Guo C, et al. Neuroprotective effects of polygalacic acid on scopolamine-induced memory deficits in mice. Phytomedicine. 2016 Feb15;23(2):149-55.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-37