Tyrphostin-23-Tyrphostin-A23-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETyrphostin 23Cat. No.: HY-15644CAS No.: 118409-57-7Synonyms: Tyrphostin A23; RG-50810; AG 18分式: CHNO分量: 186.17作靶点: EGFR作通路: JAK/STAT Signaling; Protein Tyrosine Kinase/RTK储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 month

2、s-20C 1 month溶解性数据体外实验 DMSO : 50 mg/mL (268.57 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 5.3714 mL 26.8572 mL 53.7143 mL5 mM 1.0743 mL 5.3714 mL 10.7429 mL10 mM 0.5371 mL 2.6857 mL 5.3714 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACT

3、IVITY物活性 Tyrphostin 23 (Tyrphostin A23)是EGFR 的抑制剂，IC50 值为35 M。IC50 & Target EGFR EGFR35 M (IC50, Cell Assay) 11 M (Ki)1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE体外研究 10 M tyrphostin 23 causes significant inhibition of the cell proliferation caused by 1 nM and 1M ghrelin 2.Tyrphostin 23 (T23) i

4、s a well-known inhibitor of protein tyrosine kinases and has been considered aspotential anti-cancer drug. T23 is reported to acutely stimulate the glycolytic flux in primary culturedastrocytes. Tyrphostin 23 stimulates glycolytic flux in cultured astrocytes. Mitochondrial metabolism of brainastrocy

5、tes is accelerated by Tyrphostin 23 exposure 3.REFERENCES1. Gazit A, et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989 Oct;32(10):2344-52.2. Nanzer AM, et al. Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line

6、via the mitogen-activated protein kinasepathway. Eur J Endocrinol. 2004 Aug;151(2):233-40.3. Hohnholt MC, et al. The tricarboxylic acid cycle activity in cultured primary astrocytes is strongly accelerated by the protein tyrosinekinase inhibitor tyrphostin 23. Neurochem Int. 2017 Jan;102:13-21.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 40