Silodosin-KAD-3213-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESilodosinCat. No.: HY-10122CAS No.: 160970-54-7Synonyms: KAD 3213; KMD 3213分式: CHFNO分量: 495.53作靶点: Adrenergic Receptor作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶

2、解性数据体外实验 DMSO : 50 mg/mL (100.90 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.0180 mL 10.0902 mL 20.1804 mL5 mM 0.4036 mL 2.0180 mL 4.0361 mL10 mM 0.2018 mL 1.0090 mL 2.0180 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前

3、请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.05 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.05 mM); Clear solution1/2

4、 Master of Small Molecules 您边的抑制剂师www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.05 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Silodosin (Rapaflo; KMD-3213)是1-肾上腺素受体拮抗剂。户使本产品发表的科研献 Eur J Pharmacol. 2018 Nov 15;839:82-88.See more customer validations on HYPERLINK / www.MedChem

5、EREFERENCES1. Kobayashi, Shinya; Tomiyama, Yoshitaka; Effects of silodosin and tamsulosin on the urethra and cardiovascular system in young andold dogs with benign prostatic hyperplasia. European Journal of Pharmacology (2009), 613(1-3), 135-140.2. Tatemichi, Satoshi; Tomiyama, Yoshitaka; Maruyama,

6、Itaru; Uroselectivity in male dogs of silodosin (KMD-3213), a novel drug for theobstructive component of benign prostatic hyperplasia. Neurourology and Urodynamics (2006), 25(7), 792-794.3. Osman NI, Chapple CR, Cruz F, Desgrandchamps F, Llorente C, Montorsi F.Silodosin : a new subtype selective alp

7、ha-1 antagonist forthe treatment of lower urinary tract symptoms in patients with benign prostatic hyperplasia.Expert Opin Pharmacother. 2012 Oc4. Cui Y, Zong H, Zhang Y.The efficacy and safety of silodosin in treating BPH: a systematic review and meta-analysis.Int Urol Nephrol.2012 Aug 24.5. Goseki

8、 T, Ishikawa H, Ogasawara S, Mashimo K, Nemoto N, Taguchi Y, Yago K, Shimizu K.Effects of tamsulosin and silodosin onisolated albino and pigmented rabbit iris dilators: Possible mechanism of intraoperative floppy-iris syndrome.J Cataract Refract SuMcePdfHeightCaution: Product has not been fully validated for medical applications.F