Ro-25-6981-Maleate - iGluR 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERo 25-6981 MaleateCat. No.: HY-13993ACAS No.: 1312991-76-6分式: CHNO分量: 455.54作靶点: iGluR作通路: Membrane Transporter/Ion Channel; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO

2、: 61 mg/mL (133.91 mM)H2O : 8.33 mg/mL (18.29 mM; ultrasonic and warming and heat to 45C)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.1952 mL 10.9760 mL 21.9520 mL5 mM 0.4390 mL 2.1952 mL 4.3904 mL10 mM 0.2195 mL 1.0976 mL 2.1952 mL请根据产品在不同溶剂中的溶解度，选择合适

3、的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Ro 25-6981是包含NR2B亚基的NMDA受体选择性阻断剂，对于重 组型NR1C/NR2B 和 NR1C/NR2A受体的IC50为0.009 和 52 M。REFERENCES1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE1. Fischer G, et al. Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containi

4、ng the NR2B subunit.Characterization in vitro. J Pharmacol Exp Ther. 1997 Dec;283(3):1285-92.2. Lynch DR, et al. Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit. Eur J Pharmacol.2001 Mar 30;416(3):185-95.3. Jiang M, et al. Antinociception and preventio

5、n of hyperalgesia by intrathecal administration of Ro 25-6981, a highly selective antagonistof the 2B subunit of N-methyl-D-aspartate receptor. Pharmacol Biochem Behav. 2013 Nov;112:56-63.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5895