Fluvastatin-sodium-XU-62320-sodium-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEFluvastatin sodiumCat. No.: HY-14664ACAS No.: 93957-55-2Synonyms: XU 62320 sodium分式: CHFNNaO+分量: 434.46作靶点: HMG-CoA Reductase (HMGCR); Autophagy作通路: Metabolic Enzyme/Protease; Autophagy储存式: Powder -20C 3 years4C 2 yearsIn solven

2、t -80C 6 months-20C 1 month溶解性数据体外实验 H2O : 50 mg/mL (115.09 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.3017 mL 11.5085 mL 23.0171 mL5 mM 0.4603 mL 2.3017 mL 4.6034 mL10 mM 0.2302 mL 1.1509 mL 2.3017 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Fl

3、uvastatin sodium (XU 62320 sodium)是HMG-CoA还原酶竞争性抑制剂。IC50 & Target HMGCR 1.体外研究Fluvastatin (XU 62320) is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR),the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol1/2 Master

4、 of Small Molecules 您边的抑制剂师www.MedChemEbiosynthesis. Human hepatocellular carcinoma cell (HCC) studies indicate that Fluvastatin (XU 62320)induces G2/M phase arrest. In the presence of Fluvastatin (XU 62320), HCC cells show a decrease of Bcl-2and procaspase-9 expression, and an increase in Bax, clea

5、ved caspase-3, and cytochrome c. Fluvastatin(XU 62320) is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovasculardisease.户使本产品发表的科研献 Mol Med Rep. 2018 Mar;17(3):3944-3950.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Arajo FA, Rocha MA, Capettin

6、i LS, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreasesinflammatory angiogenesis in mice. APMIS. 2012 24. Epub ahead of print2. Makabe S, Takahashi Y, Watanabe H, et al. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2

7、-dependent antioxidant pathway. Atherosclerosis. 2010 Dec;213(2):377-84.3. Zhang W, Wu J, Zhou L, et al. Fluvastatin, a lipophilic statin, induces apoptosis in human hepatocellular carcinoma cells throughmitochondria-operated pathway. Indian J Exp Biol. 2010 Dec;48(12):1167-74.4. Scripture CD, Pieper JA. Clinical pharmacokinetics of fluvastatin. Clin Pharmacokinet. 2001;40(4):263-81.McePdfHeightCaution: Product has not been fully validated for medical applications.For resear