NGR-peptide-Trifluoroacetate - Aminopeptidase - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENGR peptide TrifluoroacetateCat. No.: HY-P1043A分式: CHFNOS分量: 722.72Sequence: Cys-Asn-Gly-Arg-Cys-GlySequence Shortening: CNGRCG作靶点: Aminopeptidase作通路: Metabolic Enzyme/Protease储存式: Powder -80C 2 years-20C 1 yearIn solvent -80C 6

2、 months-20C 1 month溶解性数据体外实验 H2O : 100 mg/mL (138.37 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.3837 mL 6.9183 mL 13.8366 mL5 mM 0.2767 mL 1.3837 mL 2.7673 mL10 mM 0.1384 mL 0.6918 mL 1.3837 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL

3、 ACTIVITY物活性 NGR peptide Trifluoroacetate含有天冬酰胺-氨酸-精氨酸 (NGR)基序的肽，NGR peptide (NGR 肽) 可靶向肿瘤新管上细胞特异过量表达的 CD13 受体。IC50 & Target CD13/aminopeptidase N (APN) receptor 11/2 Master of Small Molecules 您边的抑制剂师www.MedChemE体外研究 NGR peptide can selectively bind to APN/CD13 either immune-captured or expressed on

4、 the surface of cells,the receptor of the tumor-homing NGR peptide was suspected to be APN/CD13. The NGR peptide isreported to have the greatest tumor selectivity. An anti-cancer drug Doxorubicin (DOX) coupled to an NGRpeptide displays enhanced anti-tumor effects with even lower toxicity than the fr

5、ee drug itself 2.体内研究 NGR peptide imaging in vivo not only provides more insight into NGRs targeting process, including bio-distribution and pharmacokinetics, but also reveals angiogenic activities related to tumor progression andmalignancy 2.REFERENCES1. Enyedi KN, et al. NGR-peptide-drug conjugate

6、s with dual targeting properties. NGR-peptide-drug conjugates with dual targetingproperties.2. Wang RE, et al. Development of NGR peptide-based agents for tumor imaging. Am J Nucl Med Mol Imaging. 2011;1(1):36-46.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-82