AQ-13-dihydrochloride _Parasite 抑制剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAQ-13 dihydrochlorideCat. No.: HY-100358CAS No.: 169815-40-1分式: CHClN分量: 364.74作靶点: Parasite作通路: Anti-infection储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 80 mg/mL (219.33 mM; Need ultr

2、asonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.7417 mL 13.7084 mL 27.4168 mL5 mM 0.5483 mL 2.7417 mL 5.4834 mL10 mM 0.2742 mL 1.3708 mL 2.7417 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当

3、保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.67 mg/mL (7.32 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.67 mg/mL (7.32 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.67 mg/mL (7.32 mM);

4、Clear solution; Need warming1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 AQ-13 dihydrochloride种能有效对抗恶性疟原 (Plasmodium falciparum) 的抗氯喹啉抗疟药。体内研究 Slight decreases in the PCE/RBC ratio are observed in male and female rats treated with CQ and in femalesonly treated with AQ-13;

5、however, none of these changes is statistically significant 1.PROTOCOLAnimal Rats 1Administration 1 Male and female Sprague-Dawley rats are used and are 8-9 weeks of age at the time of dose administration.Micronucleus evaluations are conducted in conjunction with repeatdose toxicity studies. Rats ar

6、e orallyadministered AQ-13 or CQ in water. Rats are given a “loading dose” followed by maintenance doses of one-half the loading dose administered 12 hr later and daily thereafter for 6 additional days 1.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. Riccio ES, et al. Genetic toxicology testing of the antimalarial drugs chloroquine and a new analog, AQ-13. Environ Mol Mutagen.2001;38(1):69-79.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only