5-6-Dihydrouridine-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE5,6-DihydrouridineCat. No.: HY-113047CAS No.: 5627-05-4分式: CHNO分量: 247.21作靶点: Endogenous Metabolite作通路: Metabolic Enzyme/Protease储存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性数据体外实

2、验 DMSO : 125 mg/mL (505.64 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.0451 mL 20.2257 mL 40.4514 mL5 mM 0.8090 mL 4.0451 mL 8.0903 mL10 mM 0.4045 mL 2.0226 mL 4.0451 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄

3、清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (8.41 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (8.41 mM); Clear solution3. 请依序

4、添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (8.41 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 5,6-Dihydrouridine在细 ，真核物和些古细菌中的 tRNA 的 D-环中的保守位置中发现的修饰碱基。IC50 & Target Human Endogenous Metabolite体外研究 5,6-Dihydrouridine (Dihydrouridine) is one of t

5、he posttranscriptionally modified nucleosides. It is a product ofthe reduction of uridine (U), and can be further modified to 5-methyldihydrouridine (m5D). 5,6-Dihydrouridineis commonly present in the tRNA from Bacteria, Eukaryota, and some Archaea. It is identified in six positionsin the “D-loop” o

6、f the tRNA (16, 17, 20a, 20b) and in position 47 in the variable loop 1.户使本产品发表的科研献 Preprints. 2019 Jun.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Kasprzak JM, et al. Molecular evolution of dihydrouridine synthases. BMC Bioinformatics. 2012 Jun 28;13:153.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400