TUG-891-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETUG-891Cat. No.: HY-100881CAS No.: 1374516-07-0分式: CHFO分量: 364.41作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 180 mg/mL (493.95 mM)* means soluble, but saturation u

2、nknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.7442 mL 13.7208 mL 27.4416 mL5 mM 0.5488 mL 2.7442 mL 5.4883 mL10 mM 0.2744 mL 1.3721 mL 2.7442 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保

3、存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.86 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.86 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师

4、www.MedChemESolubility: 2.5 mg/mL (6.86 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 TUG-891是有效的，选择性的长链游离脂肪酸受体4 (LCFA receptor 4) 的激动剂。体外研究 TUG-891 displays similar signaling properties to the LCFA -linolenic acid at human FFA4, includingstimulation of Ca2+ mobilization, -arrestin-1 and -arrestin-2 rec

5、ruitment, and extracellular signal-regulatedkinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation andinternalization of the receptor 1.REFERENCES1. Hudson BD, et al. The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120),demonstrates both potential opportunity and possible challenges to therapeutic agonism. Mol Pharmacol. 2013 Nov;84(5):710-25.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-37