HhAntag _Gli 抑制剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEHhAntagCat. No.: HY-15412CAS No.: 496794-70-8分式: CHClNO分量: 450.92作靶点: Gli作通路: Stem Cell/Wnt储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (221.77 mM)H2O : 40% PEG300 5% Tween-80

2、45% salineSolubility: 3 mg/mL (6.65 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 3 mg/mL (6.65 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 HhAntag是GLI1介导的转录抑制剂，具有抗肿瘤活性。REFERENCES1. Actis, Marcelo; Connelly, Michele C.; Mayasundari,

3、Anand et al. A structure-activity relationship study of small-molecule inhibitors ofGLI1-mediated transcription. Biopolymers (2011), 95(1), 24-30.2. Mahindroo, Neeraj; Connelly, Michele C.; Punchihewa, Chandanamali; et al. Amide conjugates of ketoprofen and indole as inhibitors ofGli1-mediated trans

4、cription in the Hedgehog pathway. Bioorganic & Medicinal Chemistry (2010), 18(13), 4801-4811.3. Yauch, Robert L.; Gould, Stephen E.; Scales, Suzie J.; et al. A paracrine requirement for hedgehog signalling in cancer. Nature (London,United Kingdom) (2008), 455(7211), 406-410.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 0