Fexofenadine-hydrochloride-MDL-16455-hydrochloride-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEFexofenadine hydrochlorideCat. No.: HY-B0801ACAS No.: 153439-40-8Synonyms: MDL-16455 hydrochloride; Terfenidine carboxylatehydrochloride分式: CHClNO分量: 538.12作靶点: Histamine Receptor作通路: GPCR/G Protein; Immunology/Inflammation; Neu

2、ronalSignaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (185.83 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.8583 mL 9.2916 mL 18.5832 mL5 mM 0.3717 mL 1.8583 mL 3.7166 mL10 mM 0.1858 mL 0.9292

3、mL 1.8583 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.65 mM); Clear solution1/2 Master of

4、Small Molecules 您边的抑制剂师www.MedChemE2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (4.65 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Fexofenadine hydrochloride (MDL-16455 hydrochloride)种 H1R 拮抗剂，可于治疗季节性过敏性炎和慢性特发性荨疹（针对年龄于16岁的） 1。IC50 & Target H1R 1体外研究 Fexofenadine hydrochloride (MDL-16455 hyd

5、rochloride) (100 M; 1 hour) effectively blocks phosphorylatedp38 activation in histamine-induced nasal fibroblasts 2.Western Blot Analysis 2Cell Line: Nasal FibroblastsConcentration: 100 MIncubation Time: 1 hourResult: Effectively blocked phosphorylated p38 activation in histamine-induced nasal fibr

6、oblasts.体内研究 Fexofenadine hydrochloride (MDL-16455 hydrochloride) (5-20 mg/kg; oral daily for 3 weeks) dose-dependently suppresses eosinophilia in C57BL/6 mice infected with T. spiralis 1.Animal Model: C57BL/6 mice 1Dosage: 5, 10, 20 mg/kgAdministration: Orally; daily for 3 weeksResult: Specifically

7、 dose-dependently suppressed eosinophilia in C57BL/6 mice infected with T.spiralis.REFERENCES1. Watanabe N, et al. The effects of fexofenadine on eosinophilia and systemic anaphylaxis in mice infected with Trichinella spiralis. IntImmunopharmacol. 2004 Mar;4(3):367-75.2. Park IH, et al. Histamine Promotes the Release of Interleukin-6 via the H1R/p38 and NF-B Pathways in NasalFibroblasts. AllergyAsthma Immunol Res. 2014 Nov;6(6):567-72.McePdfHeightCaution: Product has not been fully validated for medical applications.For res