Macropa-NH2-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMacropa-NH2Cat. No.: HY-111895CAS No.: 2146095-13-6分式: CHNO分量: 547.6作靶点: Others作通路: Others储存式: Please store the product under the recommended conditions inthe COA.溶解性数据体外实验 DMSO : 83.33 mg/mL (152.17 mM; Need ultrasonic)Mass Sol

2、vent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.8262 mL 9.1308 mL 18.2615 mL5 mM 0.3652 mL 1.8262 mL 3.6523 mL10 mM 0.1826 mL 0.9131 mL 1.8262 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂

3、在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (3.80 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (3.80 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (3.80 mM); Clear solutionBI

4、OLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 Macropa-NH2是Macropa-NCS 的前体。Macropa-NCS能与曲妥珠单抗以及前列腺特异性膜抗原靶向化合物RPS-070结合， 种可应于治疗软组织转移瘤的放射性核素 1 2。REFERENCES1. Thiele NA, et al. An Eighteen-Membered Macrocyclic Ligand for Actinium-225 Targeted Alpha Therapy. Angew Chem Int Ed Engl. 2017Nov 13;56(46):14712-14717.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax