Linoleic-acid _Endogenous Metabolite - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELinoleic acidCat. No.: HY-N0729CAS No.: 60-33-3分式: CHO分量: 280.45作靶点: Endogenous Metabolite作通路: Metabolic Enzyme/Protease储存式: Pure form -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 43.33 mg/mL (154.5

2、0 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.5657 mL 17.8285 mL 35.6570 mL5 mM 0.7131 mL 3.5657 mL 7.1314 mL10 mM 0.3566 mL 1.7828 mL 3.5657 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性

3、，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.17 mg/mL (7.74 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.17 mg/mL (7.74 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn

4、oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.17 mg/mL (7.74 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Linoleic acid多不饱和脂 酸的种关键组分。IC50 & Target Human Endogenous Metabolite体外研究 Linoleic acid contains unsaturated double bonds that are highly vulnerable to free radical attack andoxi

5、dation. If ROS are produced in great quantities, the body can no longer efficiently remove them. In suchinstances, ROS may be released into the extracellular space, causing damage to surrounding cells andtissues. Linoleic acid is a decomposition product of a free fatty acid and has been linked to erythrocytedamage 1.REFERENCES1. Yuan T, et al. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism. Int J Clin Exp Pathol. 2015 May1;8(5):5044-52.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-